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Abstract

Current guidelines recommend hepatitis C virus (HCV) testing for HIV-infected men who have sex with men (MSM) with ongoing risk behaviour, without specifying the type of risk behaviour. We developed and validated the HCV-MOSAIC risk score to assist HCV testing in HIV-infected MSM. The risk score consisted of six self-reported risk factors identified using multivariable logistic regression using data from the Dutch MOSAIC study (n = 213, 2009–2013). Area under the ROC curve (AUC), sensitivity, specificity, post-test-probability-of-disease and diagnostic gain were calculated. The risk score was validated in case–control studies from Belgium (n = 142, 2010–2013) and the United Kingdom (n = 190, 2003–2005) and in cross-sectional surveys at a Dutch sexually transmitted infections clinic (n = 284, 2007–2009). The AUC was 0.82; sensitivity 78.0% and specificity 78.6%. In the validation studies sensitivity ranged from 73.1% to 100% and specificity from 56.2% to 65.6%. The post-test-probability-of-disease ranged from 5.9% to 20.0% given acute HCV prevalence of 1.7% to 6.4%, yielding a diagnostic gain of 4.2% to 13.6%. The HCV-MOSAIC risk score can successfully identify HIV-infected MSM at risk for acute HCV infection. It could be a promising tool to improve HCV testing strategies in various settings.

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/content/10.2807/1560-7917.ES.2017.22.21.30540
2017-05-25
2018-04-20
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2017.22.21.30540
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Development and validation of the HCV-MOSAIC risk score to assist testing for acute hepatitis C virus (HCV) infection in HIV-infected men who have sex with men (MSM)
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Astrid+M+Newsum&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Newsum Astrid M</a>, <a href="/search?value1=Ineke+G+Stolte&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Stolte Ineke G</a>, <a href="/search?value1=Jan+TM+van+der+Meer&option1=author&noRedirect=true" class="nonDisambigAuthorLink">van der Meer Jan TM</a>, <a href="/search?value1=Janke+Schinkel&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Schinkel Janke</a>, <a href="/search?value1=Marc+van+der+Valk&option1=author&noRedirect=true" class="nonDisambigAuthorLink">van der Valk Marc</a>, <a href="/search?value1=Joost+W+Vanhommerig&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Vanhommerig Joost W</a>, <a href="/search?value1=Anne+Buv%C3%A9&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Buvé Anne</a>, <a href="/search?value1=Mark+Danta&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Danta Mark</a>, <a href="/search?value1=Arjan+Hogewoning&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hogewoning Arjan</a>, <a href="/search?value1=Maria+Prins&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Prins Maria</a>, <a href="/search?value1=on+behalf+of+the+MOSAIC+%28MSM+Observational+Study+of+Acute+Infection+with+hepatitis+C%29+study+group&option1=author&noRedirect=true" class="nonDisambigAuthorLink">on behalf of the MOSAIC (MSM Observational Study of Acute Infection with hepatitis C) study group</a></span>. Development and validation of the HCV-MOSAIC risk score to assist testing for acute hepatitis C virus (HCV) infection in HIV-infected men who have sex with men (MSM). <a href="/content/ecdc">Euro Surveill.</a> 2017;22(21):pii=30540. <a href="https://doi.org/10.2807/1560-7917.ES.2017.22.21.30540" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2017.22.21.30540</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 25 May 2016;&nbsp;&nbsp; <span class="generated">Accepted</span>: 22 Dec 2016 </span> </p>
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