-
Development and validation of the HCV-MOSAIC risk score to assist testing for acute hepatitis C virus (HCV) infection in HIV-infected men who have sex with men (MSM)
- Astrid M Newsum1,2 , Ineke G Stolte1 , Jan TM van der Meer2 , Janke Schinkel3 , Marc van der Valk2 , Joost W Vanhommerig1,3 , Anne Buvé4 , Mark Danta5 , Arjan Hogewoning6 , Maria Prins1,2 , on behalf of the MOSAIC (MSM Observational Study of Acute Infection with hepatitis C) study group7
-
View Affiliations Hide AffiliationsAffiliations: 1 Department of Infectious Diseases Research and Prevention, Public Health Service of Amsterdam, Amsterdam, the Netherlands 2 Department of Internal Medicine, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, the Netherlands 3 Department of Medical Microbiology, Academic Medical Center, Amsterdam, the Netherlands 4 Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium 5 St Vincent’s Clinical School, University of New South Wales, Sydney, Australia 6 STI Outpatient Clinic, Public Health Service of Amsterdam, Amsterdam, the Netherlands 7 The members of the group are listed at the end of the articleAstrid M Newsumanewsum ggd.amsterdam.nl
-
View Citation Hide Citation
Citation style for this article: Newsum Astrid M, Stolte Ineke G, van der Meer Jan TM, Schinkel Janke, van der Valk Marc, Vanhommerig Joost W, Buvé Anne, Danta Mark, Hogewoning Arjan, Prins Maria, on behalf of the MOSAIC (MSM Observational Study of Acute Infection with hepatitis C) study group. Development and validation of the HCV-MOSAIC risk score to assist testing for acute hepatitis C virus (HCV) infection in HIV-infected men who have sex with men (MSM). Euro Surveill. 2017;22(21):pii=30540. https://doi.org/10.2807/1560-7917.ES.2017.22.21.30540 Received: 25 May 2016; Accepted: 22 Dec 2016
Abstract
Current guidelines recommend hepatitis C virus (HCV) testing for HIV-infected men who have sex with men (MSM) with ongoing risk behaviour, without specifying the type of risk behaviour. We developed and validated the HCV-MOSAIC risk score to assist HCV testing in HIV-infected MSM. The risk score consisted of six self-reported risk factors identified using multivariable logistic regression using data from the Dutch MOSAIC study (n = 213, 2009–2013). Area under the ROC curve (AUC), sensitivity, specificity, post-test-probability-of-disease and diagnostic gain were calculated. The risk score was validated in case–control studies from Belgium (n = 142, 2010–2013) and the United Kingdom (n = 190, 2003–2005) and in cross-sectional surveys at a Dutch sexually transmitted infections clinic (n = 284, 2007–2009). The AUC was 0.82; sensitivity 78.0% and specificity 78.6%. In the validation studies sensitivity ranged from 73.1% to 100% and specificity from 56.2% to 65.6%. The post-test-probability-of-disease ranged from 5.9% to 20.0% given acute HCV prevalence of 1.7% to 6.4%, yielding a diagnostic gain of 4.2% to 13.6%. The HCV-MOSAIC risk score can successfully identify HIV-infected MSM at risk for acute HCV infection. It could be a promising tool to improve HCV testing strategies in various settings.

Article metrics loading...

-
From This Site
/content/10.2807/1560-7917.ES.2017.22.21.30540dcterms_title,dcterms_subject,pub_keyword-contentType:Journal -contentType:Contributor -contentType:Concept -contentType:Institution105 -
PubMed
-
Google Scholar

Full text loading...
References
-
van de Laar TJ, Matthews GV, Prins M, Danta M. Acute hepatitis C in HIV-infected men who have sex with men: an emerging sexually transmitted infection. AIDS. 2010;24(12):1799-812. https://doi.org/10.1097/QAD.0b013e32833c11a5 PMID: 20601854
-
Kaplan-Lewis E, Fierer DS. Acute HCV in HIV-infected MSM: modes of acquisition, liver fibrosis, and treatment. Curr HIV/AIDS Rep. 2015;12(3):317-25. https://doi.org/10.1007/s11904-015-0279-3 PMID: 26152661
-
Hagan H, Jordan AE, Neurer J, Cleland CM. Incidence of sexually transmitted hepatitis C virus infection in HIV-positive men who have sex with men. AIDS. 2015;29(17):2335-45. https://doi.org/10.1097/QAD.0000000000000834 PMID: 26258525
-
van Santen DK. on behalf of the CASCADE Collaboration in EuroCoord. No Decline in Hepatitis C Virus (HCV) Incidence among HIV-positive Men who Have Sex with Men (MSM) within CASCADE: 1990-2014. European AIDS Conference. Barcelona. 21-24 Oct 2015. Abstract. BPD2/7.
-
American Association for the Study of Liver Disease (AASLD) / Infectious Diseases Society of America (IDSA) / International AIDS Society (IAS)–USA. HCV testing and linkage to care. [Accessed 4 Apr 2016]. Available from: http://www.hcvguidelines.org/full-report/hcv-testing-and-linkage-care
-
Nederlandse Vereniging van Hiv-behandelaren. [Dutch Association of HIV treating physicians]. Richtlijn HIV. [HIV guidelines]. [Accessed 4 Apr 2016]. Dutch. Available from: http://richtlijnhiv.nvhb.nl/index.php/Hoofdpagina
-
European AIDS Treatment Network (NEAT) Acute Hepatitis C Infection Consensus Panel. Acute hepatitis C in HIV-infected individuals: recommendations from the European AIDS Treatment Network (NEAT) consensus conference. AIDS. 2011;25(4):399-409. PMID: 21139491
-
Thomson EC, Nastouli E, Main J, Karayiannis P, Eliahoo J, Muir D, et al. Delayed anti-HCV antibody response in HIV-positive men acutely infected with HCV. AIDS. 2009;23(1):89-93. https://doi.org/10.1097/QAD.0b013e32831940a3 PMID: 19050390
-
Vanhommerig JW, Thomas XV, van der Meer JT, Geskus RB, Bruisten SM, Molenkamp R, et al. Hepatitis C virus (HCV) antibody dynamics following acute HCV infection and reinfection among HIV-infected men who have sex with men. Clin Infect Dis. 2014;59(12):1678-85. https://doi.org/10.1093/cid/ciu695 PMID: 25186590
-
Martin NK, Vickerman P, Dore GJ, Hickman M. The hepatitis C virus epidemics in key populations (including people who inject drugs, prisoners and MSM): the use of direct-acting antivirals as treatment for prevention. Curr Opin HIV AIDS. 2015;10(5):374-80. https://doi.org/10.1097/COH.0000000000000179 PMID: 26248124
-
Wand H, Iversen J, Wilson D, Topp L, Maher L. Developing and validating a scoring tool for identifying people who inject drugs at increased risk of hepatitis C virus infection. BMJ Open. 2012;2(1):e000387. https://doi.org/10.1136/bmjopen-2011-000387 PMID: 22218720
-
Bharti AR, Letendre SL, Wolfson T, Clifford D, Collier AC, Gelman B, et al. Clinical variables identify seronegative HCV co-infection in HIV-infected individuals. J Clin Virol. 2011;52(4):328-32. https://doi.org/10.1016/j.jcv.2011.08.021 PMID: 21924674
-
Nguyen MT, Herrine SK, Laine CA, Ruth K, Weinberg DS. Description of a new hepatitis C risk assessment tool. Arch Intern Med. 2005;165(17):2013-8. https://doi.org/10.1001/archinte.165.17.2013 PMID: 16186472
-
Zuure F, Davidovich U, Kok G, Depla AC, Hoebe C, van den Hoek A, et al. Evaluation of a risk assessment questionnaire to assist hepatitis C screening in the general population. Euro Surveill. 2010;15(15):19539. PMID: 20429995
-
McGinn T, O’Connor-Moore N, Alfandre D, Gardenier D, Wisnivesky J. Validation of a hepatitis C screening tool in primary care. Arch Intern Med. 2008;168(18):2009-13. https://doi.org/10.1001/archinte.168.18.2009 PMID: 18852403
-
Lapane KL, Jakiche AF, Sugano D, Weng CS, Carey WD. Hepatitis C infection risk analysis: who should be screened? Comparison of multiple screening strategies based on the National Hepatitis Surveillance Program. Am J Gastroenterol. 1998;93(4):591-6. https://doi.org/10.1111/j.1572-0241.1998.170_b.x PMID: 9576453
-
Lambers FA, Brinkman K, Schinkel J, Spijkerman IJ, Molenkamp R, Coutinho RA, et al. Treatment of acute hepatitis C virus infection in HIV-infected MSM: the effect of treatment duration. AIDS. 2011;25(10):1333-6. https://doi.org/10.1097/QAD.0b013e3283480144 PMID: 21516025
-
Vanhommerig JW, Lambers FA, Schinkel J, Geskus RB, Arends JE, van de Laar TJ, et al. Risk Factors for Sexual Transmission of Hepatitis C Virus Among Human Immunodeficiency Virus-Infected Men Who Have Sex With Men: A Case-Control Study. Open Forum Infect Dis. 2015;2(3):ofv115. PMID: 26634219
-
Apers L, Vanden Berghe W, De Wit S, Kabeya K, Callens S, Buyze J, et al. Risk factors for HCV acquisition among HIV-positive MSM in Belgium. J Acquir Immune Defic Syndr. 2015;68(5):585-93. https://doi.org/10.1097/QAI.0000000000000528 PMID: 25763786
-
Danta M, Brown D, Bhagani S, Pybus OG, Sabin CA, Nelson M, et al. Recent epidemic of acute hepatitis C virus in HIV-positive men who have sex with men linked to high-risk sexual behaviours. AIDS. 2007;21(8):983-91. https://doi.org/10.1097/QAD.0b013e3281053a0c PMID: 17457092
-
Urbanus AT, Van De Laar TJ, Geskus R, Vanhommerig JW, Van Rooijen MS, Schinkel J, et al. Trends in hepatitis C virus infections among MSM attending a sexually transmitted infection clinic; 1995-2010. AIDS. 2014;28(5):781-90. https://doi.org/10.1097/QAD.0000000000000126 PMID: 24832014
-
Newcombe RG. Interval estimation for the difference between independent proportions: comparison of eleven methods. Stat Med. 1998;17(8):873-90. https://doi.org/10.1002/(SICI)1097-0258(19980430)17:8<873::AID-SIM779>3.0.CO;2-I PMID: 9595617
-
Akobeng AK. Understanding diagnostic tests 2: likelihood ratios, pre- and post-test probabilities and their use in clinical practice. Acta Paediatr. 2007;96(4):487-91. https://doi.org/10.1111/j.1651-2227.2006.00179.x PMID: 17306009
-
Fagan TJ. Letter: Nomogram for Bayes theorem. N Engl J Med. 1975;293(5):257. https://doi.org/10.1056/NEJM197507312930513 PMID: 1143310
-
De Vries HJC, Van Doornum GJJ, Bax CJ, Van Bergen JEAM, De Bes J, Van Dam AP, et al. Multidisciplinaire Richtlijn Seksueel Overdraagbare Aandoeningen voor de 2e Lijn. [Multidisciplinary guideline Sexually Transmitted Infections for the second line]. Utrecht: Nederlandse Vereniging voor Dermatologie en Venereologie [Dutch Society for Dermatology and Venereology]; 2012. Dutch. Available from: http://www.nvdv.nl/wp-content/uploads/2014/08/Multidisciplinaire-richtlijn-SOA-voor-de-2e-lijn-2012-13.pdf
-
Sharghi N, Bosch RJ, Mayer K, Essex M, Seage GR 3rd. The development and utility of a clinical algorithm to predict early HIV-1 infection. J Acquir Immune Defic Syndr. 2005;40(4):472-8. https://doi.org/10.1097/01.qai.0000164246.49098.47 PMID: 16280704
-
Hoenigl M, Weibel N, Mehta SR, Anderson CM, Jenks J, Green N, et al. Development and validation of the San Diego Early Test Score to predict acute and early HIV infection risk in men who have sex with men. Clin Infect Dis. 2015;61(3):468-75. https://doi.org/10.1093/cid/civ335 PMID: 25904374
-
Powers KA, Miller WC, Pilcher CD, Mapanje C, Martinson FE, Fiscus SA, et al. Improved detection of acute HIV-1 infection in sub-Saharan Africa: development of a risk score algorithm. AIDS. 2007;21(16):2237-42. https://doi.org/10.1097/QAD.0b013e3282f08b4d PMID: 18090052
-
Jordan AE, Perlman DC, Neurer J, Smith DJ, Des Jarlais DC, Hagan H. Prevalence of hepatitis C virus infection among HIV+ men who have sex with men: a systematic review and meta-analysis. Int J STD AIDS. 2017;28(2):145-59. https://doi.org/10.1177/0956462416630910 PMID: 26826159
-
Lambers FA, Prins M, Thomas X, Molenkamp R, Kwa D, Brinkman K, et al. Alarming incidence of hepatitis C virus re-infection after treatment of sexually acquired acute hepatitis C virus infection in HIV-infected MSM. AIDS. 2011;25(17):F21-7. https://doi.org/10.1097/QAD.0b013e32834bac44 PMID: 21857492
-
Vanhommerig JW, van de Laar TJ, Koot M, van Rooijen MS, Schinkel J, Speksnijder AG, et al. Evaluation of a hepatitis C virus (HCV) antigen assay for routine HCV screening among men who have sex with men infected with HIV. J Virol Methods. 2015;213:147-50. https://doi.org/10.1016/j.jviromet.2014.11.026 PMID: 25528203
-
van de Laar TJ, Paxton WA, Zorgdrager F, Cornelissen M, de Vries HJ. Sexual transmission of hepatitis C virus in human immunodeficiency virus-negative men who have sex with men: a series of case reports. Sex Transm Dis. 2011;38(2):102-4. https://doi.org/10.1097/OLQ.0b013e3181ec9de5 PMID: 20706177
-
Volk JE, Marcus JL, Phengrasamy T, Hare CB. Incident Hepatitis C Virus Infections Among Users of HIV Preexposure Prophylaxis in a Clinical Practice Setting. Clin Infect Dis. 2015;60(11):1728-9. https://doi.org/10.1093/cid/civ129 PMID: 25694649
-
Molina JM, Capitant C, Spire B, Pialoux G, Cotte L, Charreau I, et al. On-Demand Preexposure Prophylaxis in Men at High Risk for HIV-1 Infection. N Engl J Med. 2015;373(23):2237-46. https://doi.org/10.1056/NEJMoa1506273 PMID: 26624850
-
McCormack S, Dunn DT, Desai M, Dolling DI, Gafos M, Gilson R, et al. Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): effectiveness results from the pilot phase of a pragmatic open-label randomised trial. Lancet. 2016;387(10013):53-60. https://doi.org/10.1016/S0140-6736(15)00056-2 PMID: 26364263
-
Ingiliz P, Martin TC, Rodger A, Stellbrink HJ, Mauss S, Boesecke C, et al. HCV reinfection incidence and spontaneous clearance rates in HIV-positive men who have sex with men in Western Europe. J Hepatol. 2017;66(2):282-7. https://doi.org/10.1016/j.jhep.2016.09.004 PMID: 27650285
-
Martin TC, Martin NK, Hickman M, Vickerman P, Page EE, Everett R, et al. Hepatitis C virus reinfection incidence and treatment outcome among HIV-positive MSM. AIDS. 2013;27(16):2551-7. https://doi.org/10.1097/QAD.0b013e32836381cc PMID: 23736152

Data & Media loading...
