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Abstract

We describe the dynamics of dengue virus (DENV) infection in a woman in her mid-30s who developed fever after returning from Sri Lanka to Italy in April 2017. Laboratory testing demonstrated detectable DENV-RNA in plasma, urine, saliva, vaginal secretion. Persistent shedding of DENV-RNA was demonstrated in vaginal secretion, and DENV-RNA was detectable in the pelleted fraction up to 18 days from symptom onset. These findings give new insights into DENV vaginal shedding and vertical transmission.

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/content/10.2807/1560-7917.ES.2017.22.34.30600
2017-08-24
2024-10-15
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2017.22.34.30600
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References

  1. Moureau G, Temmam S, Gonzalez JP, Charrel RN, Grard G, de Lamballerie X. A real-time RT-PCR method for the universal detection and identification of flaviviruses. Vector Borne Zoonotic Dis. 2007;7(4):467-77.  https://doi.org/10.1089/vbz.2007.0206  PMID: 18020965 
  2. Simmons CP, Farrar JJ, Nguyen V, Wills B. Dengue. N Engl J Med. 2012;366(15):1423-32.  https://doi.org/10.1056/NEJMra1110265  PMID: 22494122 
  3. Castro MC, Wilson ME, Bloom DE. Disease and economic burdens of dengue. Lancet Infect Dis. 2017;17(3):e70-8.  https://doi.org/10.1016/S1473-3099(16)30545-X  PMID: 28185869 
  4. Carles G, Peiffer H, Talarmin A. Effects of dengue fever during pregnancy in French Guiana. Clin Infect Dis. 1999;28(3):637-40.  https://doi.org/10.1086/515144  PMID: 10194092 
  5. Waduge R, Malavige GN, Pradeepan M, Wijeyaratne CN, Fernando S, Seneviratne SL. Dengue infections during pregnancy: a case series from Sri Lanka and review of the literature. J Clin Virol. 2006;37(1):27-33.  https://doi.org/10.1016/j.jcv.2006.06.002  PMID: 16843056 
  6. Yin X, Zhong X, Pan S. Vertical transmission of dengue infection: the first putative case reported in China. Rev Inst Med Trop Sao Paulo. 2016;58(0):90.  https://doi.org/10.1590/s1678-9946201658090  PMID: 27982356 
  7. Chye JK, Lim CT, Ng KB, Lim JM, George R, Lam SK. Vertical transmission of dengue. Clin Infect Dis. 1997;25(6):1374-7.  https://doi.org/10.1086/516126  PMID: 9431381 
  8. Perez S, Tato R, Cabrera JJ, Lopez A, Robles O, Paz E, et al. Confirmed case of Zika virus congenital infection, Spain, March 2016. Euro Surveill. 2016;21(24):30261.  https://doi.org/10.2807/1560-7917.ES.2016.21.24.30261  PMID: 27336620 
  9. Moreira J, Peixoto TM, Siqueira AM, Lamas CC. Sexually acquired Zika virus: a systematic review. Clin Microbiol Infect. 2017;23(5):296-305.  https://doi.org/10.1016/j.cmi.2016.12.027  PMID: 28062314 
  10. Murray KO, Gorchakov R, Carlson AR, Berry R, Lai L, Natrajan M, et al. Prolonged Detection of Zika Virus in Vaginal Secretions and Whole Blood. Emerg Infect Dis. 2017;23(1):99-101.  https://doi.org/10.3201/eid2301.161394  PMID: 27748649 
  11. Nicastri E, Castilletti C, Liuzzi G, Iannetta M, Capobianchi MR, Ippolito G. Persistent detection of Zika virus RNA in semen for six months after symptom onset in a traveller returning from Haiti to Italy, February 2016. Euro Surveill. 2016;21(32):30314.  https://doi.org/10.2807/1560-7917.ES.2016.21.32.30314  PMID: 27541989 
  12. Barzon L, Pacenti M, Franchin E, Lavezzo E, Trevisan M, Sgarabotto D, et al. Infection dynamics in a traveller with persistent shedding of Zika virus RNA in semen for six months after returning from Haiti to Italy, January 2016. Euro Surveill. 2016;21(32):30316.  https://doi.org/10.2807/1560-7917.ES.2016.21.32.30316  PMID: 27542178 
  13. Nicastri E, Castilletti C, Balestra P, Galgani S, Ippolito G. Zika Virus Infection in the Central Nervous System and Female Genital Tract. Emerg Infect Dis. 2016;22(12):2228-30.  https://doi.org/10.3201/eid2212.161280  PMID: 27617352 
  14. Xiong Y-Q, Mo Y, Shi T-L, Zhu L, Chen Q. Dengue virus infection during pregnancy increased the risk of adverse fetal outcomes? An updated meta-analysis. J Clin Virol. 2017;94:42-9.  https://doi.org/10.1016/j.jcv.2017.07.008  PMID: 28753531 
  15. Carroll ID, Toovey S, Van Gompel A. Dengue fever and pregnancy - a review and comment. Travel Med Infect Dis. 2007;5(3):183-8.  https://doi.org/10.1016/j.tmaid.2006.11.002  PMID: 17448946 
  16. Chan JF-W, Yip CC-Y, Tsang JO-L, Tee K-M, Cai J-P, Chik KK-H, et al. Differential cell line susceptibility to the emerging Zika virus: implications for disease pathogenesis, non-vector-borne human transmission and animal reservoirs. Emerg Microbes Infect. 2016;5(8):e93.  https://doi.org/10.1038/emi.2016.99  PMID: 27553173 
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