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Abstract

We report a summer influenza epidemic caused by co-circulation of multiple influenza A(H3N2) variants in clade 3C.2a. Compared with other clades, a putative clade 3C.2a.3a was more commonly isolated from severely ill patients; 3C.2a.4 was more commonly isolated in outbreak cases. Time from vaccination to illness onset was significantly shorter in severely ill patients infected with clade 3C.2a.3; characteristics and outcomes of patients infected with different clades were similar. No resistance to antiviral medications was found.

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/content/10.2807/1560-7917.ES.2017.22.50.17-00767
2017-12-14
2024-04-19
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2017.22.50.17-00767
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References

  1. Skowronski DM, Chambers C, Sabaiduc S, Dickinson JA, Winter AL, De Serres G, et al. Interim estimates of 2016/17 vaccine effectiveness against influenza A(H3N2), Canada, January 2017. Euro Surveill. 2017;22(6):30460.  https://doi.org/10.2807/1560-7917.ES.2017.22.6.30460  PMID: 28205503 
  2. Trebbien R, Fischer TK, Krause TG, Nielsen L, Nielsen XC, Weinreich LS, et al. Changes in genetically drifted H3N2 influenza A viruses and vaccine effectiveness in adults 65 years and older during the 2016/17 season in Denmark. J ClinVirol. 2017;94:1-7.  https://doi.org/10.1016/j.jcv.2017.06.007  PMID: 28697450 
  3. Glatman-Freedman A, Drori Y, Beni SA, Friedman N, Pando R, Sefty H, et al. Genetic divergence of Influenza A(H3N2) amino acid substitutions mark the beginning of the 2016-2017 winter season in Israel. J ClinVirol. 2017;93:71-5.  https://doi.org/10.1016/j.jcv.2017.05.020  PMID: 28672275 
  4. Harvala H, Frampton D, Grant P, Raffle J, Ferns RB, Kozlakidis Z, et al. ICONIC Consortium. Emergence of a novel subclade of influenza A(H3N2) virus in London, December 2016 to January 2017. Euro Surveill. 2017;22(8):30466.  https://doi.org/10.2807/1560-7917.ES.2017.22.8.30466  PMID: 28251889 
  5. Melidou A, Broberg EEuropean region influenza surveillance network. Predominance of influenza A(H3N2) virus genetic subclade 3C.2a1 during an early 2016/17 influenza season in Europe - Contribution of surveillance data from World Health Organization (WHO) European Region to the WHO vaccine composition consultation for northern hemisphere 2017/18. Vaccine. 2017;35(37):4828-35.  https://doi.org/10.1016/j.vaccine.2017.07.057  PMID: 28780977 
  6. Centers for Disease Control. Taiwan. Taiwan National Infectious Disease Statistics System. Taipei City: Centers for Disease Control, ROC (Taiwan). [Accessed December 11,2017].Available from: https://nidss.cdc.gov.tw/en/RODS_2.aspx?dc=rods&disease=4
  7. Centers for Disease Control. Taiwan. Taiwan Influenza Express, 2016-2017 Influenza Season. Taipei City: Centers for Disease Control, ROC (Taiwan). [Accessed December 11, 2017]. Available from: http://www.cdc.gov.tw/english/list.aspx?treeid=00ED75D6C887BB27&nowtreeid=E57ACAB3865E527D.
  8. Yang JR, Lin CH, Chen CJ, Liu JL, Huang YP, Kuo CY, et al. A new antigenic variant of human influenza A (H3N2) virus isolated from airport and community surveillance in Taiwan in early 2009. Virus Res. 2010;151(1):33-8.  https://doi.org/10.1016/j.virusres.2010.03.011  PMID: 20347893 
  9. Jian SW, Chen CM, Lee CY, Liu DP. Real-Time Surveillance of Infectious Diseases: Taiwan’s Experience. Health Secur. 2017;15(2):144-53.  https://doi.org/10.1089/hs.2016.0107  PMID: 28418738 
  10. Hergens MP, Baum U, Brytting M, Ikonen N, Haveri A, Wiman Å, et al. Mid-season real-time estimates of seasonal influenza vaccine effectiveness in persons 65 years and older in register-based surveillance, Stockholm County, Sweden, and Finland, January 2017. Euro Surveill. 2017;22(8):30469.  https://doi.org/10.2807/1560-7917.ES.2017.22.8.30469  PMID: 28251891 
  11. Rondy M, Gherasim A, Casado I, Launay O, Rizzo C, Pitigoi D, et al. I-Move Hospital Working Group. Low 2016/17 season vaccine effectiveness against hospitalised influenza A(H3N2) among elderly: awareness warranted for 2017/18 season. Euro Surveill. 2017;22(41).  https://doi.org/10.2807/1560-7917.ES.2017.22.41.17-00645  PMID: 29043961 
  12. European Centre for Disease Prevention and Control. Expert opinion on neuraminidase inhibitors for the prevention and treatment of influenza – review of recent systematic reviews and meta-analyses. Stockholm: ECDC; 2017.
  13. Koel BF, Burke DF, Bestebroer TM, van der Vliet S, Zondag GC, Vervaet G, et al. Substitutions near the receptor binding site determine major antigenic change during influenza virus evolution. Science. 2013;342(6161):976-9.  https://doi.org/10.1126/science.1244730  PMID: 24264991 
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