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Abstract

Background

Clusters of dengue cases have recently become more frequent in areas of southern France colonised by the vector mosquito . In July 2015, a 2-month outbreak of dengue virus serotype 1 (DENV-1) was reported in Nîmes. We conducted a serosurvey in the affected area at the end of the vector activity period to determine the true extent of dengue transmission. We collected capillary blood from consenting household members, and information on their medical and travel histories, and exposure to mosquito bites. Recent infections were identified using IgM and IgG anti-DENV ELISA, followed, when positive, by plaque reduction neutralisation tests on serum against DENV 1–4 and West Nile virus. The prevalence estimator was calibrated on reference demographic data. We quantified the spatial clustering of dengue cases within the affected community and inferred the transmission tree. The study participation rate was 39% (564/1,431). Three of 564 participants tested positive for DENV-1 infection (after marginal calibration, 0.41%; 95% confidence interval: 0.00–0.84). The spatial analysis showed that cases were clustered at the household level. Most participants perceived the presence of mosquitos as abundant (83%) and reported frequent mosquito bites (57%). We incidentally identified six past West Nile virus infections (0.9%; 95% CI: 0.2–1.6). This serosurvey confirms the potential for arboviral diseases to cause outbreaks − albeit limited for now − in France and Europe.

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/content/10.2807/1560-7917.ES.2018.23.23.1700482
2018-06-07
2018-10-19
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2018.23.23.1700482
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References

  1. Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL, et al. The global distribution and burden of dengue. Nature. 2013;496(7446):504-7.  https://doi.org/10.1038/nature12060  PMID: 23563266 
  2. World Health Organization (WHO). Dengue: Guidelines for Diagnosis, Treatment, Prevention and Control: New Edition. Geneva: WHO; 2009. Available from: http://www.who.int/tdr/publications/documents/dengue-diagnosis.pdf
  3. Grange L, Simon-Loriere E, Sakuntabhai A, Gresh L, Paul R, Harris E. Epidemiological risk factors associated with high global frequency of inapparent dengue virus infections. Front Immunol. 2014;5:280.  https://doi.org/10.3389/fimmu.2014.00280  PMID: 24966859 
  4. Duong V, Lambrechts L, Paul RE, Ly S, Lay RS, Long KC, et al. Asymptomatic humans transmit dengue virus to mosquitoes. Proc Natl Acad Sci USA. 2015;112(47):14688-93.  https://doi.org/10.1073/pnas.1508114112  PMID: 26553981 
  5. Rigau-Pérez JG, Clark GG, Gubler DJ, Reiter P, Sanders EJ, Vorndam AV. Dengue and dengue haemorrhagic fever. Lancet. 1998;352(9132):971-7.  https://doi.org/10.1016/S0140-6736(97)12483-7  PMID: 9752834 
  6. Medlock JM, Hansford KM, Schaffner F, Versteirt V, Hendrickx G, Zeller H, et al. A review of the invasive mosquitoes in Europe: ecology, public health risks, and control options. Vector Borne Zoonotic Dis. 2012;12(6):435-47.  https://doi.org/10.1089/vbz.2011.0814  PMID: 22448724 
  7. Liu-Helmersson J, Quam M, Wilder-Smith A, Stenlund H, Ebi K, Massad E, et al. Climate Change and Aedes Vectors: 21st Century Projections for Dengue Transmission in Europe. EBioMedicine. 2016;7:267-77.  https://doi.org/10.1016/j.ebiom.2016.03.046  PMID: 27322480 
  8. Delisle E, Rousseau C, Broche B, Leparc-Goffart I, L’Ambert G, Cochet A, et al. Chikungunya outbreak in Montpellier, France, September to October 2014. Euro Surveill. 2015;20(17):21108.  https://doi.org/10.2807/1560-7917.ES2015.20.17.21108  PMID: 25955774 
  9. Jupille H, Seixas G, Mousson L, Sousa CA, Failloux AB. Zika Virus, a New Threat for Europe? PLoS Negl Trop Dis. 2016;10(8):e0004901.  https://doi.org/10.1371/journal.pntd.0004901  PMID: 27505002 
  10. Rezza G, Nicoletti L, Angelini R, Romi R, Finarelli AC, Panning M, et al. CHIKV study group. Infection with chikungunya virus in Italy: an outbreak in a temperate region. Lancet. 2007;370(9602):1840-6.  https://doi.org/10.1016/S0140-6736(07)61779-6  PMID: 18061059 
  11. La Ruche G, Souarès Y, Armengaud A, Peloux-Petiot F, Delaunay P, Desprès P, et al. First two autochthonous dengue virus infections in metropolitan France, September 2010. Euro Surveill. 2010;15(39):19676. PMID: 20929659 
  12. Marchand E, Prat C, Jeannin C, Lafont E, Bergmann T, Flusin O, et al. Autochthonous case of dengue in France, October 2013. Euro Surveill. 2013;18(50):20661.  https://doi.org/10.2807/1560-7917.ES2013.18.50.20661  PMID: 24342514 
  13. Giron S, Rizzi J, Leparc-Goffart I, Septfons A, Tine R, Cadiou B, et al. (New occurrence of indigenous dengue cases in the Provence-Alpes-Côte d'Azur region, France, August-September 2014). Nouvelles apparitions de cas autochtones de dengue en région Provence-Alpes-Côte d’Azur, France, août-septembre 2014. Bull Epidemiol Hebd (Paris). 2015; (13-14):6.
  14. Succo T, Leparc-Goffart I, Ferré JB, Roiz D, Broche B, Maquart M, et al. Autochthonous dengue outbreak in Nîmes, South of France, July to September 2015. Euro Surveill. 2016;21(21):30240.  https://doi.org/10.2807/1560-7917.ES.2016.21.21.30240  PMID: 27254729 
  15. Ministère des affaires sociales, de la santé et des droits des femmes, France. Instruction N° DGS/RI1/2015/125 du 16 avril 2015 mettant à jour le guide relatif aux modalités de mise en oeuvre du plan anti-dissémination du chikungunya et de la dengue en métropole. [French Ministry of Social Affairs, Health and Women's Rights, France. Instruction N ° DGS / RI1 / 2015/125 of 16 April 2015 updating the implementation guide of the anti-dissemination plan for chikungunya and dengue fever in metropolitan France]. 2015. French. Available from: http://circulaire.legifrance.gouv.fr/pdf/2015/04/cir_39495.pdf
  16. D’Ortenzio E, Matheron S, Yazdanpanah Y, de Lamballerie X, Hubert B, Piorkowski G, et al. Evidence of Sexual Transmission of Zika Virus. N Engl J Med. 2016;374(22):2195-8.  https://doi.org/10.1056/NEJMc1604449  PMID: 27074370 
  17. The National Institute of Statistics and Economic Studies (Insee). Nomenclature des Profession et Catégories Socioprofessionnelles- PCS 2003. [Nomenclature of Occupation and Socio-professional Categories]. Paris: Insee. [Accessed 27 Feb 2017]. Available from: https://www.insee.fr/fr/information/2400059
  18. The National Institute of Statistics and Economic Studies (Insee). Ilots Regroupés pour l'Information Statistique (IRIS). Definition. [Aggregated geographical units for statistical information. Definition]. Paris: Insee. [Accessed 27 Feb 2017]. French. Available from: https://www.insee.fr/fr/metadonnees/definition/c1523
  19. Deville J-C, Särndal C-E, Sautory O. Generalized Raking Procedures in Survey Sampling. J Am Stat Assoc. 1993;88(423):1013-20.  https://doi.org/10.1080/01621459.1993.10476369 
  20. The National Institute of Statistics and Economic Studies (Insee). La macro SAS CALMAR. [The SAS CALMAR macro]. Paris: Insee. [Accessed 23 Feb 2017]. French. Available from: https://www.insee.fr/fr/information/2021902.
  21. Salje H, Cauchemez S, Alera MT, Rodriguez-Barraquer I, Thaisomboonsuk B, Srikiatkhachorn A, et al. Reconstruction of 60 Years of Chikungunya Epidemiology in the Philippines Demonstrates Episodic and Focal Transmission. J Infect Dis. 2016;213(4):604-10.  https://doi.org/10.1093/infdis/jiv470  PMID: 26410592 
  22. Radke EG, Gregory CJ, Kintziger KW, Sauber-Schatz EK, Hunsperger EA, Gallagher GR, et al. Dengue outbreak in Key West, Florida, USA, 2009. Emerg Infect Dis. 2012;18(1):135-7.  https://doi.org/10.3201/eid1801.110130  PMID: 22257471 
  23. Brunkard JM, Robles López JL, Ramirez J, Cifuentes E, Rothenberg SJ, Hunsperger EA, et al. Dengue fever seroprevalence and risk factors, Texas-Mexico border, 2004. Emerg Infect Dis. 2007;13(10):1477-83.  https://doi.org/10.3201/eid1310.061586  PMID: 18257990 
  24. Pem-Novosel I, Vilibic-Cavlek T, Gjenero-Margan I, Kaic B, Babic-Erceg A, Merdic E, et al. Dengue virus infection in Croatia: seroprevalence and entomological study. New Microbiol. 2015;38(1):97-100. PMID: 25821943 
  25. Delaunay P, Hubiche T, Blanc V, Perrin Y, Marty P, Del Giudice P. [Aedes albopictus in metropolitan France]. Ann Dermatol Venereol. 2012;139(5):396-401; quiz 395, 402.
  26. Effler PV, Pang L, Kitsutani P, Vorndam V, Nakata M, Ayers T, et al. Dengue fever, Hawaii, 2001-2002. Emerg Infect Dis. 2005;11(5):742-9.  https://doi.org/10.3201/eid1105.041063  PMID: 15890132 
  27. Paupy C, Ollomo B, Kamgang B, Moutailler S, Rousset D, Demanou M, et al. Comparative role of Aedes albopictus and Aedes aegypti in the emergence of Dengue and Chikungunya in central Africa. Vector Borne Zoonotic Dis. 2010;10(3):259-66.  https://doi.org/10.1089/vbz.2009.0005  PMID: 19725769 
  28. Shen SQ, Wei HX, Fu YH, Zhang H, Mo QY, Wang XJ, et al. Multiple Sources of Infection and Potential Endemic Characteristics of the Large Outbreak of Dengue in Guangdong in 2014. Sci Rep. 2015;5(1):16913.  https://doi.org/10.1038/srep16913  PMID: 26593240 
  29. Moi ML, Kobayashi D, Isawa H, Sasaki T, Saijo M, Kurane I, et al. Dengue Virus Isolation in Mosquito Aedes albopictus Captured During an Outbreak in Tokyo, 2014, by a Method Relying on Antibody-Dependent Enhancement Mechanism Using FcγR-Expressing BHK Cells. Vector Borne Zoonotic Dis. 2016;16(12):810-2.  https://doi.org/10.1089/vbz.2016.1982  PMID: 27911695 
  30. Yoon IK, Getis A, Aldstadt J, Rothman AL, Tannitisupawong D, Koenraadt CJ, et al. Fine scale spatiotemporal clustering of dengue virus transmission in children and Aedes aegypti in rural Thai villages. PLoS Negl Trop Dis. 2012;6(7):e1730.  https://doi.org/10.1371/journal.pntd.0001730  PMID: 22816001 
  31. Salje H, Lessler J, Endy TP, Curriero FC, Gibbons RV, Nisalak A, et al. Revealing the microscale spatial signature of dengue transmission and immunity in an urban population. Proc Natl Acad Sci USA. 2012;109(24):9535-8.  https://doi.org/10.1073/pnas.1120621109  PMID: 22645364 
  32. Mammen MP, Pimgate C, Koenraadt CJ, Rothman AL, Aldstadt J, Nisalak A, et al. Spatial and temporal clustering of dengue virus transmission in Thai villages. PLoS Med. 2008;5(11):e205.  https://doi.org/10.1371/journal.pmed.0050205  PMID: 18986209 
  33. Anderson KB, Gibbons RV, Cummings DA, Nisalak A, Green S, Libraty DH, et al. A shorter time interval between first and second dengue infections is associated with protection from clinical illness in a school-based cohort in Thailand. J Infect Dis. 2014;209(3):360-8.  https://doi.org/10.1093/infdis/jit436  PMID: 23964110 
  34. Alera MT, Srikiatkhachorn A, Velasco JM, Tac-An IA, Lago CB, Clapham HE, et al. Incidence of Dengue Virus Infection in Adults and Children in a Prospective Longitudinal Cohort in the Philippines. PLoS Negl Trop Dis. 2016;10(2):e0004337.  https://doi.org/10.1371/journal.pntd.0004337  PMID: 26845762 
  35. Charrel RN, de Lamballerie X, Durand JP, Gallian P, Attoui H, Biagini P, et al. Prevalence of antibody against West Nile virus in volunteer blood donors living in southeastern France. Transfusion. 2001;41(10):1320-1.  https://doi.org/10.1046/j.1537-2995.2001.41101320.x  PMID: 11606836 
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