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Abstract

Tick-borne encephalitis virus (TBEV) is an important European vaccine-preventable pathogen. Discrimination of vaccine-induced antibodies from those elicited by infection is important. We studied anti-TBEV IgM/IgG responses, including avidity and neutralisation, by multiplex serology in 50 TBEV patients and 50 TBEV vaccinees. Infection induced antibodies reactive to both whole virus (WV) and non-structural protein 1 (NS1) in 48 clinical cases, whereas 47 TBEV vaccinees had WV, but not NS1 antibodies, enabling efficient discrimination of infection/vaccination.

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/content/10.2807/1560-7917.ES.2018.23.3.17-00838
2018-01-18
2024-10-15
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2018.23.3.17-00838
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References

  1. Rönnberg B, Gustafsson Å, Vapalahti O, Emmerich P, Lundkvist Å, Schmidt-Chanasit J, et al. Compensating for cross-reactions using avidity and computation in a suspension multiplex immunoassay for serotyping of Zika versus other flavivirus infections. Med Microbiol Immunol (Berl). 2017;206(5):383-401.  https://doi.org/10.1007/s00430-017-0517-y  PMID: 28852878 
  2. Vene S, Haglund M, Vapalahti O, Lundkvist A. A rapid fluorescent focus inhibition test for detection of neutralizing antibodies to tick-borne encephalitis virus. J Virol Methods. 1998;73(1):71-5.  https://doi.org/10.1016/S0166-0934(98)00041-X  PMID: 9705177 
  3. Hertzell KB, Pauksens K, Rombo L, Knight A, Vene S, Askling HH. Tick-borne encephalitis (TBE) vaccine to medically immunosuppressed patients with rheumatoid arthritis: A prospective, open-label, multi-centre study. Vaccine. 2016;34(5):650-5.  https://doi.org/10.1016/j.vaccine.2015.12.029  PMID: 26718689 
  4. Lindquist L, Vapalahti O. Tick-borne encephalitis. Lancet. 2008;371(9627):1861-71.  https://doi.org/10.1016/S0140-6736(08)60800-4  PMID: 18514730 
  5. Dobler G, Tkachev S. General epidemiology of tick-borne encephalitis. In: Dobler G, Erber W, Schmitt HJ. TBE-The Book. Singapore: Global Health Press; 2017. ISBN: 978-981-1903-3. Available from: https://id-ea.org/tbe
  6. Tick Borne Encephalitis (TBE). Stockholm: The Public Health Agency of Sweden. [Accessed: Jan 2017. Available from: https://www.folkhalsomyndigheten.se/folkhalsorapportering-statistik/statistikdatabaser-och-visualisering/sjukdomsstatistik/tick-borne-encephalitis-tbe/?t=county
  7. Lundkvist Å. TBEV / TBE by country. Sweden. In: Dobler G, Erber W, Schmitt HJ. TBE-The Book. Singapore: Global Health Press; 2017. ISBN: 978-981-1903-3. Available from: https://id-ea.org/tbe
  8. Vene S, Haglund M, Lundkvist A, Lindquist L, Forsgren M. Study of the serological response after vaccination against tick-borne encephalitis in Sweden. Vaccine. 2007;25(2):366-72.  https://doi.org/10.1016/j.vaccine.2006.07.026  PMID: 16959384 
  9. Heinz FX, Stiasny K, Holzmann H, Grgic-Vitek M, Kriz B, Essl A, et al. Vaccination and tick-borne encephalitis, central Europe. Emerg Infect Dis. 2013;19(1):69-76.  https://doi.org/10.3201/eid1901.120458  PMID: 23259984 
  10. Andersson CR, Vene S, Insulander M, Lindquist L, Lundkvist A, Günther G. Vaccine failures after active immunisation against tick-borne encephalitis. Vaccine. 2010;28(16):2827-31.  https://doi.org/10.1016/j.vaccine.2010.02.001  PMID: 20167301 
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