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Abstract

In early September 2018, two cases of monkeypox were reported in the United Kingdom (UK), diagnosed on 7 September in Cornwall (South West England) and 11 September in Blackpool (North West England). The cases were epidemiologically unconnected and had recently travelled to the UK from Nigeria, where monkeypox is currently circulating. We describe the epidemiology and the public health response for the first diagnosed cases outside the African continent since 2003.

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/content/10.2807/1560-7917.ES.2018.23.38.1800509
2018-09-20
2024-03-19
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2018.23.38.1800509
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References

  1. Public Health England (PHE). Guidance monkeypox. The epidemiology, symptoms, diagnosis and management of monkeypox virus infections. London; PHE; 2018. Available from: https://www.gov.uk/guidance/monkeypox
  2. Bavarian Nordic. Summary of product characteristics - Imvanex. Kvistgaard: Bavarian Nordic; 2018. Available from: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002596/WC500147896.pdf
  3. Breman JG, Kalisa-Ruti, Steniowski MV, Zanotto E, Gromyko AI, Arita I. Human monkeypox, 1970-79. Bull World Health Organ. 1980;58(2):165-82. PMID: 6249508 
  4. Jezek Z, Fenner F. Human monkeypox. In: Melnick J, ed. Monographs in virology. Vol. 17. New York: Karger, 1988.
  5. McCollum AM, Damon IK. Human monkeypox. Clin Infect Dis. 2014;58(2):260-7.  https://doi.org/10.1093/cid/cit703  PMID: 24158414 
  6. Reynolds MG, Yorita KL, Kuehnert MJ, Davidson WB, Huhn GD, Holman RC, et al. Clinical manifestations of human monkeypox influenced by route of infection. J Infect Dis. 2006;194(6):773-80.  https://doi.org/10.1086/505880  PMID: 16941343 
  7. World Health Organization (WHO). Monkeypox. Fact sheet. Geneva: WHO; 2018. Available from: http://www.who.int/news-room/fact-sheets/detail/monkeypox
  8. Damon IK. Status of human monkeypox: clinical disease, epidemiology and research. Vaccine. 2011;29(29) Suppl 4;D54-9.  https://doi.org/10.1016/j.vaccine.2011.04.014  PMID: 22185831 
  9. Di Giulio DB, Eckburg PB. Human monkeypox: an emerging zoonosis. Lancet Infect Dis. 2004;4(1):15-25.  https://doi.org/10.1016/S1473-3099(03)00856-9  PMID: 14720564 
  10. Nolen LD, Osadebe L, Katomba J, Likofata J, Mukadi D, Monroe B, et al. Introduction of monkeypox into a community and household: risk factors and zoonotic reservoirs in the Democratic Republic of the Congo. Am J Trop Med Hyg. 2015;93(2):410-5.  https://doi.org/10.4269/ajtmh.15-0168  PMID: 26013374 
  11. Khodakevich L, Szczeniowski M, Manbu-ma-Disu, Jezek Z, Marennikova S, Nakano J, et al. The role of squirrels in sustaining monkeypox virus transmission. Trop Geogr Med. 1987;39(2):115-22. PMID: 2820094 
  12. Khodakevich L, Jezek Z, Messinger D. Monkeypox virus: ecology and public health significance. Bull World Health Organ. 1988;66(6):747-52. PMID: 2853010 
  13. Parker S, Buller RM. A review of experimental and natural infections of animals with monkeypox virus between 1958 and 2012. Future Virol. 2013;8(2):129-57.  https://doi.org/10.2217/fvl.12.130  PMID: 23626656 
  14. Ladnyj ID, Ziegler P, Kima E. A human infection caused by monkeypox virus in Basankusu Territory, Democratic Republic of the Congo. Bull World Health Organ. 1972;46(5):593-7. PMID: 4340218 
  15. Rimoin AW, Mulembakani PM, Johnston SC, Lloyd Smith JO, Kisalu NK, Kinkela TL, et al. Major increase in human monkeypox incidence 30 years after smallpox vaccination campaigns cease in the Democratic Republic of Congo. Proc Natl Acad Sci USA. 2010;107(37):16262-7.  https://doi.org/10.1073/pnas.1005769107  PMID: 20805472 
  16. Nigeria Centre for Disease Control (NCDC). Re: Monkeypox Cases in the United Kingdom. Abuja: NCDC; 2018. Available from: https://ncdc.gov.ng/news/152/re%3A-monkeypox-cases-in-the-united-kingdom
  17. Likos AM, Sammons SA, Olson VA, Frace AM, Li Y, Olsen-Rasmussen M, et al. A tale of two clades: monkeypox viruses. J Gen Virol. 2005;86(Pt 10):2661-72.  https://doi.org/10.1099/vir.0.81215-0  PMID: 16186219 
  18. Saijo M, Ami Y, Suzaki Y, Nagata N, Iwata N, Hasegawa H, et al. Virulence and pathophysiology of the Congo Basin and West African strains of monkeypox virus in non-human primates. J Gen Virol. 2009;90(Pt 9):2266-71.  https://doi.org/10.1099/vir.0.010207-0  PMID: 19474247 
  19. Learned LA, Reynolds MG, Wassa DW, Li Y, Olson VA, Karem K, et al. Extended interhuman transmission of monkeypox in a hospital community in the Republic of the Congo, 2003. Am J Trop Med Hyg. 2005;73(2):428-34.  https://doi.org/10.4269/ajtmh.2005.73.428  PMID: 16103616 
  20. Yinka-Ogunleye A, Aruna O, Ogoina D, Aworabhi N, Eteng W, Badaru S, et al. Reemergence of human monkeypox in Nigeria, 2017. Emerg Infect Dis. 2018;24(6):1149-51.  https://doi.org/10.3201/eid2406.180017  PMID: 29619921 
  21. Reynolds MG, Davidson WB, Curns AT, Conover CS, Huhn G, Davis JP, et al. Spectrum of infection and risk factors for human monkeypox, United States, 2003. Emerg Infect Dis. 2007;13(9):1332-9.  https://doi.org/10.3201/eid1309.070175  PMID: 18252104 
  22. Centers for Disease Control and Prevention (CDC). Update: multistate outbreak of monkeypox--Illinois, Indiana, Kansas, Missouri, Ohio, and Wisconsin, 2003. MMWR Morb Mortal Wkly Rep. 2003;52(27):642-6. PMID: 12855947 
  23. Hatch GJ, Graham VA, Bewley KR, Tree JA, Dennis M, Taylor I, et al. Assessment of the protective effect of Imvamune and Acam2000 vaccines against aerosolized monkeypox virus in cynomolgus macaques. J Virol. 2013;87(14):7805-15.  https://doi.org/10.1128/JVI.03481-12  PMID: 23658452 
  24. Bavarian Nordic. About Imvanex. Kvistgaard: Bavarian Nordic. [Accessed: 14 September 2018]. Available from: http://www.imvanex.com/about-imvanex.php
  25. Vollmar J, Arndtz N, Eckl KM, Thomsen T, Petzold B, Mateo L, et al. Safety and immunogenicity of IMVAMUNE, a promising candidate as a third generation smallpox vaccine. Vaccine. 2006;24(12):2065-70.  https://doi.org/10.1016/j.vaccine.2005.11.022  PMID: 16337719 
  26. European Medicines Agency (EMA). Imvanex: modified vaccinia Ankara virus. Summary of European public assessment report on Imvanex. London: EMA. [Accessed: 14 September 2018]. Available from: http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/002596/human_med_001666.jsp&mid=WC0b01ac058001d124
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