1887
Surveillance and outbreak report Open Access
Like 0

Abstract

Molecular technology to identify relatedness between complex isolates, representative of possible tuberculosis (TB) transmission between individuals, continues to evolve. At the same time, tools to utilise this information for public health action to improve TB control should also be implemented. Public Health England developed the Strain Typing Module (STM) as an integral part of the web-based surveillance system used in the United Kingdom following the roll-out of prospective 24 loci mycobacterial interspersed repetitive unit-variable number tandem repeat (MIRU-VNTR) strain typing. The creation of such a system required data integration and linkage, bringing together laboratory results and patient notification information. The STM facilitated widespread access to patient strain typing and clustering results for the public health community working in TB control. In addition, the system provided a log of cluster review and investigation decision making and results. Automated real-time data linkage between laboratory and notification data are essential to allow routine use of genotyping results in TB surveillance and control. Outputs must be accessible by those working in TB control at a local level to have any impact in ongoing public health activity.

Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2018.23.44.1700794
2018-11-01
2019-01-17
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2018.23.44.1700794
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/23/44/eurosurv-23-44-4.html?itemId=/content/10.2807/1560-7917.ES.2018.23.44.1700794&mimeType=html&fmt=ahah

References

  1. Public Health England (PHE). Reports of cases of tuberculosis to enhanced tuberculosis surveillance systems: UK, 2000 to 2015. Official statistics. London: PHE; 2016 Available from: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/555298/TB_Official_Statistics_2016_GTW2309.pdf
  2. Department of Health (DH). Stopping tuberculosis in England: an action plan from the Chief Medical Officer. London: DH; 2004 Available from: http://webarchive.nationalarchives.gov.uk/20121105041001/http://www.dh.gov.uk/prod_consum_dh/groups/dh_digitalassets/@dh/@en/documents/digitalasset/dh_4100860.pdf
  3. Public Health England (PHE). National TB strain typing service: what we do. London: PHE; 2014. Available from: https://www.gov.uk/guidance/national-tb-strain-typing-service-what-we-do
  4. Public Health England (PHE). TB strain typing and cluster investigation handbook. 3rd ed. London: PHE; 2014. Available from: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/433055/TB_Strain_Typing_Handbook_final_070214__2_.pdf
  5. Barnes PF, Cave MD. Molecular epidemiology of tuberculosis. N Engl J Med. 2003;349(12):1149-56.  https://doi.org/10.1056/NEJMra021964  PMID: 13679530 
  6. Public Health England (PHE). Tuberculosis (TB) strain typing service: evaluation. London: PHE; 2013. Available from: https://www.gov.uk/government/publications/tuberculosis-tb-strain-typing-service-evaluation
  7. Black AT, Hamblion EL, Buttivant H, Anderson SR, Stone M, Casali N, et al. Tracking and responding to an outbreak of tuberculosis using MIRU-VNTR genotyping and whole genome sequencing as epidemiological tools. J Public Health (Oxf). 2018;40(2):e66-73.  https://doi.org/10.1093/pubmed/fdx075  PMID: 29106587 
  8. Lalor MK, Anderson LF, Hamblion EL, Burkitt A, Davidson JA, Maguire H, et al. Recent household transmission of tuberculosis in England, 2010-2012: retrospective national cohort study combining epidemiological and molecular strain typing data. BMC Med. 2017;15(1):105.  https://doi.org/10.1186/s12916-017-0864-y  PMID: 28606177 
  9. NHS number. Leeds: NHS Digital. [Accessed 29 Mar 2018]. Available from: https://digital.nhs.uk/NHS-Number
  10. Public Health England (PHE). Tuberculosis in England: 2016 report (presenting data to end of 2015). London: PHE; 2016. Available from: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/654294/TB_Annual_Report_2016_GTW2309_errata_v1.2.pdf
  11. Gardy JL, Johnston JC, Ho Sui SJ, Cook VJ, Shah L, Brodkin E, et al. Whole-genome sequencing and social-network analysis of a tuberculosis outbreak. N Engl J Med. 2011;364(8):730-9.  https://doi.org/10.1056/NEJMoa1003176  PMID: 21345102 
  12. Ghosh S, Moonan PK, Cowan L, Grant J, Kammerer S, Navin TR. Tuberculosis genotyping information management system: enhancing tuberculosis surveillance in the United States. Infect Genet Evol. 2012;12(4):782-8.  https://doi.org/10.1016/j.meegid.2011.10.013  PMID: 22044522 
  13. Pankhurst LJ, Del Ojo Elias C, Votintseva AA, Walker TM, Cole K, Davies J, et al. Rapid, comprehensive, and affordable mycobacterial diagnosis with whole-genome sequencing: a prospective study. Lancet Respir Med. 2016;4(1):49-58.  https://doi.org/10.1016/S2213-2600(15)00466-X  PMID: 26669893 
  14. Tagliani E, Cirillo DM, Ködmön C, van der Werf MJEUSeqMyTB Consortium. EUSeqMyTB to set standards and build capacity for whole genome sequencing for tuberculosis in the EU. Lancet Infect Dis. 2018;18(4):377.  https://doi.org/10.1016/S1473-3099(18)30132-4  PMID: 29582760 
/content/10.2807/1560-7917.ES.2018.23.44.1700794
Loading

Data & Media loading...

Comment has been disabled for this content
Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error