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We investigated influenza A(H5N6) viruses from migratory birds in Chungnam and Gyeonggi Provinces, South Korea following a reported die-off of poultry in nearby provinces in November 2017. Genetic analysis and virulence studies in chickens and ducks identified our isolate from December 2017 as a novel highly pathogenic avian influenza virus. It resulted from reassortment between the highly virulent H5N8 strain from Korea with the N6 gene from a low-pathogenic H3N6 virus from the Netherlands.


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  1. World Organisation for Animal Health (OIE). H5N6 Update on avian influenza in animals (types H5 and H7). Paris: OIE; 19 Nov 2017. Available from: http://www.oie.int/wahis_2/temp/reports/en_imm_0000025260_20171120_171201.pdf
  2. World Organisation for Animal Health (OIE). H5N6 Update on avian influenza in animals (types H5 and H7). Paris: OIE; 10 Nov 2017. Available from: http://www.oie.int/wahis_2/temp/reports/en_imm_0000025189_20171110_182530.pdf
  3. Beerens N, Heutink R, Bergervoet SA, Harders F, Bossers A, Koch G. Multiple Reassorted Viruses as Cause of Highly Pathogenic Avian Influenza A(H5N8) Virus Epidemic, the Netherlands, 2016. Emerg Infect Dis. 2017;23(12):1974-81.  https://doi.org/10.3201/eid2312.171062  PMID: 29148396 
  4. Si Y-J, Lee IW, Kim E-H, Kim Y-I, Kwon H-I, Park S-J, et al. Genetic characterisation of novel, highly pathogenic avian influenza (HPAI) H5N6 viruses isolated in birds, South Korea, November 2016. Euro Surveill. 2017;22(1):30434.  https://doi.org/10.2807/1560-7917.ES.2017.22.1.30434  PMID: 28079520 
  5. Pohlmann A, Starick E, Harder T, Grund C, Höper D, Globig A, et al. Outbreaks among wild birds and domestic poultry caused by reassorted influenza A (H5N8) clade 2.3. 4.4 viruses, Germany, 2016. Emerg Infect Dis. 2017;23(4):633-6.  https://doi.org/10.3201/eid2304.161949  PMID: 28055819 
  6. World Organisation for Animal Health (OIE). Infection with avian influenza viruses. In: Terrestrial Animal Health Code. Paris: OIE; 2017 Available from: http://www.oie.int/index.php?id=169&L=0&htmfile=chapitre_avian_influenza_viruses.htm
  7. Shen H, Wu B, Chen Y, Bi Y, Xie Q. Influenza A(H5N6) virus reassortant, southern China, 2014. Emerg Infect Dis. 2015;21(7):1261-2.  https://doi.org/10.3201/eid2107.140838  PMID: 26079430 
  8. Wong FY, Phommachanh P, Kalpravidh W, Chanthavisouk C, Gilbert J, Bingham J, et al. Reassortant highly pathogenic influenza A(H5N6) virus in Laos. Emerg Infect Dis. 2015;21(3):511-6.  https://doi.org/10.3201/eid2103.141488  PMID: 25695754 
  9. Lu S, Zhao Z, Zhang J, Wang W, He X, Yu M, et al. Genetics, pathogenicity and transmissibility of novel reassortant H5N6 highly pathogenic avian influenza viruses first isolated from migratory birds in western China. Emerg Microbes Infect. 2018;7(1):6.  https://doi.org/10.1038/s41426-017-0001-1  PMID: 29362400 
  10. World Organisation for Animal Health (OIE). H5N6 Update on avian influenza in animals (types H5 and H7). Paris: OIE; 23 Nov 2017. Available from: http://www.oie.int/wahis_2/public%5C.%5Ctemp%5Creports/en_imm_0000021637_20161123_134128.pdf
  11. World Organisation for Animal Health (OIE). H5N8 Update on avian influenza in animals (types H5 and H7). Paris: OIE; 20 Nov 2017. Available from: http://www.oie.int/wahis_2/temp/reports/en_fup_0000025168_20171120_170003.pdf
  12. Kim Y-I, Park S-J, Kwon H-I, Kim E-H, Si Y-J, Jeong J-H, et al. Genetic and phylogenetic characterizations of a novel genotype of highly pathogenic avian influenza (HPAI) H5N8 viruses in 2016/2017 in South Korea. Infect Genet Evol. 2017;53:56-67.  https://doi.org/10.1016/j.meegid.2017.05.001  PMID: 28477974 
  13. Globig A, Baumer A, Revilla-Fernández S, Beer M, Wodak E, Fink M, et al. Ducks as sentinels for avian influenza in wild birds. Emerg Infect Dis. 2009;15(10):1633-6.  https://doi.org/10.3201/eid1510.090439  PMID: 19861060 
  14. Kim Y-I, Pascua PNQ, Kwon H-I, Lim G-J, Kim E-H, Yoon S-W, et al. Pathobiological features of a novel, highly pathogenic avian influenza A(H5N8) virus. Emerg Microbes Infect. 2014;3(10):e75.  https://doi.org/10.1038/emi.2014.75  PMID: 26038499 
  15. Lee Y-J, Kang H-M, Lee E-K, Song B-M, Jeong J, Kwon Y-K, et al. Novel reassortant influenza A(H5N8) viruses, South Korea, 2014. Emerg Infect Dis. 2014;20(6):1087-9.  https://doi.org/10.3201/eid2006.140233  PMID: 24856098 
  16. Adlhoch C, Gossner C, Koch G, Brown I, Bouwstra R, Verdonck F, et al. Comparing introduction to Europe of highly pathogenic avian influenza viruses A(H5N8) in 2014 and A(H5N1) in 2005. Euro Surveill. 2014;19(50):20996.  https://doi.org/10.2807/1560-7917.ES2014.19.50.20996  PMID: 25597538 
  17. Poen MJ, Bestebroer TM, Vuong O, Scheuer RD, van der Jeugd HP, Kleyheeg E, et al. Local amplification of highly pathogenic avian influenza H5N8 viruses in wild birds in the Netherlands, 2016 to 2017. Euro Surveill. 2018;23(4):17-00449.  https://doi.org/10.2807/1560-7917.ES.2018.23.4.17-00449  PMID: 29382414 
  18. Lee D-H, Torchetti MK, Winker K, Ip HS, Song C-S, Swayne DE. Intercontinental spread of Asian-origin H5N8 to North America through Beringia by migratory birds. J Virol. 2015;89(12):6521-4.  https://doi.org/10.1128/JVI.00728-15  PMID: 25855748 

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