1887
Rapid communication Open Access
Like 0

Abstract

A hepatitis A outbreak has occurred in Chile since November 2016. Men are predominantly affected, with a large proportion of men who have sex with men (MSM). We describe 12 consecutive unrelated confirmed cases who presented at our healthcare institution in Santiago Metropolitan Area. Nine were men, all reporting having had sex with men. Ten viral sequences, genotyped as IA, clustered with the V16–25801 strain causing outbreaks mostly in MSM in Europe since mid-2016.

Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2018.23.9.18-00060
2018-03-01
2018-12-15
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2018.23.9.18-00060
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/23/9/eurosurv-23-9-2.html?itemId=/content/10.2807/1560-7917.ES.2018.23.9.18-00060&mimeType=html&fmt=ahah

References

  1. Corey L, Holmes KK. Sexual transmission of hepatitis A in homosexual men: incidence and mechanism. N Engl J Med. 1980;302(8):435-8.  https://doi.org/10.1056/NEJM198002213020804  PMID: 6243391 
  2. Centers for Disease Control and Prevention (CDC). Sexual Transmission and Viral Hepatitis. Atlanta: CDC. [Accessed 22 Feb 2018]. Available from: https://www.cdc.gov/hepatitis/populations/stds.htm
  3. Beebeejaun K, Degala S, Balogun K, Simms I, Woodhall SC, Heinsbroek E, et al. Outbreak of hepatitis A associated with men who have sex with men (MSM), England, July 2016 to January 2017. Euro Surveill. 2017;22(5).  https://doi.org/10.2807/1560-7917.ES.2017.22.5.30454  PMID: 28183392 
  4. Freidl GS, Sonder GJ, Bovée LP, Friesema IH, van Rijckevorsel GG, Ruijs WL, et al. Hepatitis A outbreak among men who have sex with men (MSM) predominantly linked with the EuroPride, the Netherlands, July 2016 to February 2017. Euro Surveill. 2017;22(8):30468.  https://doi.org/10.2807/1560-7917.ES.2017.22.8.30468  PMID: 28251892 
  5. Gozlan Y, Bar-Or I, Rakovsky A, Savion M, Amitai Z, Sheffer R, et al. Ongoing hepatitis A among men who have sex with men (MSM) linked to outbreaks in Europe in Tel Aviv area, Israel, December 2016 - June 2017. Euro Surveill. 2017;22(29):30575.  https://doi.org/10.2807/1560-7917.ES.2017.22.29.30575  PMID: 28749336 
  6. Rodríguez-Tajes S, Perpiñán E, Caballol B, Lens S, Mariño Z, Costa J, et al. Hepatitis A outbreak in Barcelona among men who have sex with men (MSM), January-June 2017: A hospital perspective. Liver Int. 2017.  https://doi.org/10.1111/liv.13606  PMID: 28980376 
  7. European Centre for Disease Prevention and Control (ECDC). Hepatitis A outbreaks in the EU/EEA mostly affecting men who have sex with men – third update, 28 June 2017. Stockholm: ECDC; 2017 Jun. Available from: https://ecdc.europa.eu/sites/portal/files/documents/RRA%20hep%20A%20outbreak%20EU%20EEA%20in%20MSM%20third%20update%2028%20June%202017_0.pdf
  8. Furlow B. Large hepatitis A outbreaks in USA constrain vaccine supply. Lancet Gastroenterol Hepatol. 2017;2(12):848-9.  https://doi.org/10.1016/S2468-1253(17)30329-1  PMID: 29079410 
  9. Virus Hepatitis A y E. Instituto de Salud Pública de Chile. Spanish. [Accessed 1 Feb 2018]. Available from: http://www.ispch.cl/virus-hepatitis-y-e
  10. Departamento de Epidemiología. Minsal. Chile. Informe de situación epidemiológica de Hepatitis A. Semana Epidemiológica 1-40. Chile. Spanish. [Accessed 23 Nov 2017]. Available from: http://epi.minsal.cl/boletin-epidemiologico-trimestral-edicion3-2017/
  11. Ríos I. Informe de situación epidemiológica de Hepatitis A y viral sin especificación. Departamento de Epidemiología. Minsal. Chile. Spanish. [Accessed 26 Oct 2017]. Available from: http://epi.minsal.cl/wp-content/uploads/2017/10/BET_HEPATITIS_SEPTIEMBRE_2017.pdf
  12. Dutch National Institute for Public Health and the Environment (RIVM). Protocol for Molecular Detection and typing of VP1 region of Hepatitis A Virus. Bilthoven: RIVM. [Accessed 26 Nov 2017]. Available from: http://www.rivm.nl/en/Topics/H/HAVNET/Protocols/Typing_protocol_HAVNET_VP1P2A.org
  13. European Centre for Disease Prevention and Control (ECDC). Epidemiological update: hepatitis A outbreak in the EU/EEA mostly affecting men who have sex with men. Stockholm: ECDC; 29 Sep 2017. [Accessed 2 Feb 2018]. Available from: https://ecdc.europa.eu/en/news-events/epidemiological-update-hepatitis-outbreak-eueea-mostly-affecting-men-who-have-sex-men
  14. Fix AD, Martin OS, Gallicchio L, Vial PA, Lagos R. Age-specific prevalence of antibodies to hepatitis A in Santiago, Chile: risk factors and shift in age of infection among children and young adults. Am J Trop Med Hyg. 2002;66(5):628-32.  https://doi.org/10.4269/ajtmh.2002.66.628  PMID: 12201603 
  15. Ciocca M, Moreira-Silva SF, Alegría S, Galoppo MC, Ruttiman R, Porta G, et al. Hepatitis A as an etiologic agent of acute liver failure in Latin America. Pediatr Infect Dis J. 2007;26(8):711-5.  https://doi.org/10.1097/INF.0b013e3180f60bed  PMID: 17848883 
  16. Villena R, Wilhelm J, Calvo X, Cerda J, Escobar C, Moreno G, et al. Opinión del Comité Consultivo de Inmunizaciones de la Sociedad Chilena de Infectología en relación a los brotes de hepatitis A en Chile. [Statement of the Advisory Committee on Immunizations of Sociedad Chilena de Infectología about outbreaks of hepatitis A in Chile]. Rev Chilena Infectol. 2017;34(4):371-3.  https://doi.org/10.4067/s0716-10182017000400371  PMID: 29165515 
  17. Valenzuela MT, Jacobs RJ, Arteaga O, Navarrete MS, Meyerhoff AS, Innis BL. Cost-effectiveness of universal childhood hepatitis A vaccination in Chile. Vaccine. 2005;23(32):4110-9.  https://doi.org/10.1016/j.vaccine.2005.03.021  PMID: 15964479 
  18. Espul C, Benedetti L, Linares M, Cuello H, Lo Castro I, Thollot Y, et al. Seven-year follow-up of the immune response after one or 2 doses of inactivated hepatitis A vaccine given at 1 year of age in the Mendoza Province of Argentina. Hum Vaccin Immunother. 2017;13(11):2707-12.  https://doi.org/10.1080/21645515.2017.1358326  PMID: 28933624 
  19. Urueña A, González JE, Rearte A, Pérez Carrega ME, Calli R, Pagani MF, et al. Single-dose Universal Hepatitis A Immunization in One-year-old Children in Argentina: High Prevalence of Protective Antibodies up to 9 Years After Vaccination. Pediatr Infect Dis J. 2016;35(12):1339-42.  https://doi.org/10.1097/INF.0000000000001322  PMID: 27636725 
/content/10.2807/1560-7917.ES.2018.23.9.18-00060
Loading

Data & Media loading...

Comment has been disabled for this content
Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error