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Emergence of divergent enterovirus (EV) D68 sub-clade D1 strains, northern Italy, September to October 2018
- Laura Pellegrinelli1 , Federica Giardina2 , Giovanna Lunghi3 , Sara Colonia Uceda Renteria3 , Letizia Greco3 , Alice Fratini2 , Cristina Galli1 , Antonio Piralla2 , Sandro Binda1 , Elena Pariani1 , Fausto Baldanti2,4
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View Affiliations Hide AffiliationsAffiliations: 1 Department of Biomedical Sciences for Health, University of Milan, Milan, Italy 2 Molecular Virology Unit, Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy 3 Microbiology and Virology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy 4 Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, ItalyAntonio Pirallaa.piralla smatteo.pv.it
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Citation style for this article: Pellegrinelli Laura, Giardina Federica, Lunghi Giovanna, Uceda Renteria Sara Colonia , Greco Letizia, Fratini Alice, Galli Cristina, Piralla Antonio, Binda Sandro, Pariani Elena, Baldanti Fausto. Emergence of divergent enterovirus (EV) D68 sub-clade D1 strains, northern Italy, September to October 2018. Euro Surveill. 2019;24(7):pii=1900090. https://doi.org/10.2807/1560-7917.ES.2018.24.7.1900090 Received: 31 Jan 2019; Accepted: 13 Feb 2019
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Abstract
Between September and October 2018, an enterovirus D68 (EV-D68) outbreak occurred in patients hospitalised with severe acute respiratory infection in northern Italy; 21 laboratory-confirmed cases were reported. Phylogenetic analysis revealed that 16/20 of the EV-D68 sequences belonged to a divergent group within the sub-clade D1. Since its upsurge, EV-D68 has undergone rapid evolution with the emergence of new viral variants, emphasising the need for molecular surveillance that include outpatients with respiratory illness.

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