1887
  1. Home
  2. Eurosurveillance
  3. Volume 24, Issue 7, 14/Feb/2019
  4. Article
Rapid communication Open Access
Like 0
Download

Abstract

Between September and October 2018, an enterovirus D68 (EV-D68) outbreak occurred in patients hospitalised with severe acute respiratory infection in northern Italy; 21 laboratory-confirmed cases were reported. Phylogenetic analysis revealed that 16/20 of the EV-D68 sequences belonged to a divergent group within the sub-clade D1. Since its upsurge, EV-D68 has undergone rapid evolution with the emergence of new viral variants, emphasising the need for molecular surveillance that include outpatients with respiratory illness.

© Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2018.24.7.1900090
2019-02-14
2020-10-01
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2018.24.7.1900090
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/24/7/eurosurv-24-7-1.html?itemId=/content/10.2807/1560-7917.ES.2018.24.7.1900090&mimeType=html&fmt=ahah

References

  1. Piralla A, Girello A, Premoli M, Baldanti F. A new real-time reverse transcription-PCR assay for detection of human enterovirus 68 in respiratory samples. J Clin Microbiol. 2015;53(5):1725-6.  https://doi.org/10.1128/JCM.03691-14  PMID: 25694533 
  2. Poelman R, Schuffenecker I, Van Leer-Buter C, Josset L, Niesters HGM, Lina B. European surveillance for enterovirus D68 during the emerging North-American outbreak in 2014. J Clin Virol. 2015;71:1-9.  https://doi.org/10.1016/j.jcv.2015.07.296  PMID: 26364237 
  3. Piralla A, Girello A, Grignani M, Gozalo-Margüello M, Marchi A, Marseglia G, et al. Phylogenetic characterization of enterovirus 68 strains in patients with respiratory syndromes in Italy. J Med Virol. 2014;86(9):1590-3.  https://doi.org/10.1002/jmv.23821  PMID: 24155220 
  4. Trifinopoulos J, Nguyen LT, von Haeseler A, Minh BQ. W-IQ-TREE: a fast online phylogenetic tool for maximum likelihood analysis. Nucleic Acids Res. 2016;44(W1):W232-5.  https://doi.org/10.1093/nar/gkw256  PMID: 27084950 
  5. Gong YN, Yang SL, Shih SR, Huang YC, Chang PY, Huang CG, et al. Molecular evolution and the global reemergence of enterovirus D68 by genome-wide analysis. Medicine (Baltimore). 2016;95(31):e4416.  https://doi.org/10.1097/MD.0000000000004416  PMID: 27495059 
  6. Yip CCY, Lo JYC, Sridhar S, Lung DC, Luk S, Chan KH, et al. First Report of a Fatal Case Associated with EV-D68 Infection in Hong Kong and Emergence of an Interclade Recombinant in China Revealed by Genome Analysis. Int J Mol Sci. 2017;18(5):E1065. PMID: 28509856 
  7. Piralla A, Lilleri D, Sarasini A, Marchi A, Zecca M, Stronati M, et al. Human rhinovirus and human respiratory enterovirus (EV68 and EV104) infections in hospitalized patients in Italy, 2008-2009. Diagn Microbiol Infect Dis. 2012;73(2):162-7.  https://doi.org/10.1016/j.diagmicrobio.2012.02.019  PMID: 22494556 
  8. Holm-Hansen CC, Midgley SE, Fischer TK. Global emergence of enterovirus D68: a systematic review. Lancet Infect Dis. 2016;16(5):e64-75.  https://doi.org/10.1016/S1473-3099(15)00543-5  PMID: 26929196 
  9. Piralla A, Principi N, Ruggiero L, Girello A, Giardina F, De Sando E, et al. Enterovirus-D68 (EV-D68) in pediatric patients with respiratory infection: The circulation of a new B3 clade in Italy. J Clin Virol. 2018;99-100:91-6.  https://doi.org/10.1016/j.jcv.2018.01.005  PMID: 29396353 
  10. Giombini E, Rueca M, Barberi W, Iori AP, Castilletti C, Scognamiglio P, et al. Enterovirus D68-Associated Acute Flaccid Myelitis in Immunocompromised Woman, Italy. Emerg Infect Dis. 2017;23(10):1690-3.  https://doi.org/10.3201/eid2310.170792  PMID: 28930024 
  11. Esposito S, Chidini G, Cinnante C, Napolitano L, Giannini A, Terranova L, et al. Acute flaccid myelitis associated with enterovirus-D68 infection in an otherwise healthy child. Virol J. 2017;14(1):4.  https://doi.org/10.1186/s12985-016-0678-0  PMID: 28081720 
  12. Messacar K, Asturias EJ, Hixon AM, Van Leer-Buter C, Niesters HGM, Tyler KL, et al. Enterovirus D68 and acute flaccid myelitis-evaluating the evidence for causality. Lancet Infect Dis. 2018;18(8):e239-47.  https://doi.org/10.1016/S1473-3099(18)30094-X  PMID: 29482893 
  13. Hixon AM, Yu G, Leser JS, Yagi S, Clarke P, Chiu CY, et al. A mouse model of paralytic myelitis caused by enterovirus D68. PLoS Pathog. 2017;13(2):e1006199.  https://doi.org/10.1371/journal.ppat.1006199  PMID: 28231269 
  14. Dyda A, Stelzer-Braid S, Adam D, Chughtai AA, MacIntyre CR. The association between acute flaccid myelitis (AFM) and Enterovirus D68 (EV-D68) - what is the evidence for causation? Euro Surveill. 2018;23(3):17-00310.  https://doi.org/10.2807/1560-7917.ES.2018.23.3.17-00310  PMID: 29386095 
  15. Devi S. US CDC task force to investigate acute flaccid myelitis cases. Lancet. 2018;392(10162):2339.  https://doi.org/10.1016/S0140-6736(18)33012-5  PMID: 30527604 
  16. Eshaghi A, Duvvuri VR, Isabel S, Banh P, Li A, Peci A, et al. Global Distribution and Evolutionary History of Enterovirus D68, with Emphasis on the 2014 Outbreak in Ontario, Canada. Front Microbiol. 2017;8:257.  https://doi.org/10.3389/fmicb.2017.00257  PMID: 28298902 
  17. Cottrell S, Moore C, Perry M, Hilvers E, Williams C, Shankar AG. Prospective enterovirus D68 (EV-D68) surveillance from September 2015 to November 2018 indicates a current wave of activity in Wales. Euro Surveill. 2018;23(46):1800578.  https://doi.org/10.2807/1560-7917.ES.2018.23.46.1800578  PMID: 30458915 
  18. Midgley CM, Watson JT, Nix WA, Curns AT, Rogers SL, Brown BA, et al. Severe respiratory illness associated with a nationwide outbreak of enterovirus D68 in the USA (2014): a descriptive epidemiological investigation. Lancet Respir Med. 2015;3(11):879-87.  https://doi.org/10.1016/S2213-2600(15)00335-5  PMID: 26482320 
  19. Martin G, Li R, Cook VE, Carwana M, Tilley P, Sauve L, et al. Respiratory Presentation of Pediatric Patients in the 2014 Enterovirus D68 Outbreak. Can Respir J. 2016;2016:8302179.  https://doi.org/10.1155/2016/8302179  PMID: 27610028 
  20. Linsuwanon P, Puenpa J, Suwannakarn K, Auksornkitti V, Vichiwattana P, Korkong S, et al. Molecular epidemiology and evolution of human enterovirus serotype 68 in Thailand, 2006-2011. PLoS One. 2012;7(5):e35190.  https://doi.org/10.1371/journal.pone.0035190  PMID: 22586446 
  21. Kumar S, Stecher G, Tamura K. MEGA7: Molecular Evolutionary Genetics Analysis version 7.0 for bigger datasets. Mol Biol Evol. 2016;33(7):1870-4.  https://doi.org/10.1093/molbev/msw054  PMID: 27004904 
  22. Bal A, Sabatier M, Wirth T, Coste-Burel M, Lazrek M, Stefic K, et al. Emergence of enterovirus D68 clade D1, France, August to November 2018. Euro Surveill. 2019;24(3):1800699.  https://doi.org/10.2807/1560-7917.ES.2019.24.3.1800699  PMID: 30670143 
Emergence of divergent enterovirus (EV) D68 sub-clade D1 strains, northern Italy, September to October 2018
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Laura+Pellegrinelli&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pellegrinelli Laura</a> , <a href="/search?value1=Federica+Giardina&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Giardina Federica</a> , <a href="/search?value1=Giovanna+Lunghi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lunghi Giovanna</a> , <a href="/search?value1=Sara+Colonia++Uceda+Renteria&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Uceda Renteria Sara Colonia </a> , <a href="/search?value1=Letizia+Greco&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Greco Letizia</a> , <a href="/search?value1=Alice+Fratini&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fratini Alice</a> , <a href="/search?value1=Cristina+Galli&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Galli Cristina</a> , <a href="/search?value1=Antonio+Piralla&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Piralla Antonio</a> , <a href="/search?value1=Sandro+Binda&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Binda Sandro</a> , <a href="/search?value1=Elena+Pariani&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pariani Elena</a> , <a href="/search?value1=Fausto+Baldanti&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Baldanti Fausto</a> </span>. Emergence of divergent enterovirus (EV) D68 sub-clade D1 strains, northern Italy, September to October 2018. <a href="/content/ecdc">Euro Surveill.</a> 2019;24(7):pii=1900090. <a href="https://doi.org/10.2807/1560-7917.ES.2018.24.7.1900090" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2018.24.7.1900090</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 31 Jan 2019;&nbsp;&nbsp; <span class="generated">Accepted</span>: 13 Feb 2019 </span> </p>
/content/10.2807/1560-7917.ES.2018.24.7.1900090
/content/10.2807/1560-7917.ES.2018.24.7.1900090
Loading

Data & Media loading...

Comment has been disabled for this content
Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error