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- Emi Takashita1, Chiharu Kawakami2, Rie Ogawa1, Hiroko Morita1, Seiichiro Fujisaki1, Masayuki Shirakura1, Hideka Miura1, Kazuya Nakamura1, Noriko Kishida1, Tomoko Kuwahara1, Akira Ota3, Hayato Togashi3, Ayako Saito4, Keiko Mitamura5, Takashi Abe6, Masataka Ichikawa7, Masahiko Yamazaki8, Shinji Watanabe1, Takato Odagiri1
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View Affiliations Hide AffiliationsAffiliations: 1 Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan 2 Yokohama City Institute of Public Health, Kanagawa, Japan 3 Saiseikai Yokohamashi Nanbu Hospital, Kanagawa, Japan 4 Saito Children’s Clinic, Kanagawa, Japan 5 Eiju General Hospital, Tokyo, Japan 6 Abe Children’s Clinic, Kanagawa, Japan 7 Ichikawa Children’s Clinic, Kanagawa, Japan 8 Zama Children’s Clinic, Kanagawa, JapanCorrespondence:Takato Odagiritodagiri nih.go.jp
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Citation style for this article: Takashita Emi, Kawakami Chiharu, Ogawa Rie, Morita Hiroko, Fujisaki Seiichiro, Shirakura Masayuki, Miura Hideka, Nakamura Kazuya, Kishida Noriko, Kuwahara Tomoko, Ota Akira, Togashi Hayato, Saito Ayako, Mitamura Keiko, Abe Takashi, Ichikawa Masataka, Yamazaki Masahiko, Watanabe Shinji, Odagiri Takato. Influenza A(H3N2) virus exhibiting reduced susceptibility to baloxavir due to a polymerase acidic subunit I38T substitution detected from a hospitalised child without prior baloxavir treatment, Japan, January 2019. Euro Surveill. 2019;24(12):pii=1900170. https://doi.org/10.2807/1560-7917.ES.2019.24.12.1900170 Received: 06 Mar 2019; Accepted: 21 Mar 2019
Influenza A(H3N2) virus exhibiting reduced susceptibility to baloxavir due to a polymerase acidic subunit I38T substitution detected from a hospitalised child without prior baloxavir treatment, Japan, January 2019
Abstract
In January 2019, two influenza A(H3N2) viruses carrying an I38T substitution in the polymerase acidic subunit (PA), which confers reduced susceptibility to baloxavir, were detected from epidemiologically unrelated hospitalised children in Japan. The viruses exhibited reduced susceptibility to baloxavir but were susceptible to neuraminidase inhibitors. Only one of the two children had been treated with baloxavir. An epidemiological analysis suggests possible transmission of the PA I38T mutant A(H3N2) virus among humans.
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/content/10.2807/1560-7917.ES.2019.24.12.1900170
2019-03-21
2019-06-19
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2019.24.12.1900170
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References
-
Takashita E, Kawakami C, Morita H, Ogawa R, Fujisaki S, Shirakura M, et al. On Behalf Of The Influenza Virus Surveillance Group Of Japan. Detection of influenza A(H3N2) viruses exhibiting reduced susceptibility to the novel cap-dependent endonuclease inhibitor baloxavir in Japan, December 2018. Euro Surveill. 2019;24(3). https://doi.org/10.2807/1560-7917.ES.2019.24.3.1800698 PMID: 30670142
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Omoto S, Speranzini V, Hashimoto T, Noshi T, Yamaguchi H, Kawai M, et al. Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil. Sci Rep. 2018;8(1):9633. https://doi.org/10.1038/s41598-018-27890-4 PMID: 29941893
-
Takashita E, Morita H, Ogawa R, Nakamura K, Fujisaki S, Shirakura M, et al. Susceptibility of Influenza Viruses to the Novel Cap-Dependent Endonuclease Inhibitor Baloxavir Marboxil. Front Microbiol. 2018;9(3026):3026. https://doi.org/10.3389/fmicb.2018.03026 PMID: 30574137
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Gubareva LV, Mishin VP, Patel MC, Chesnokov A, Nguyen HT, De La Cruz J, et al. Assessing baloxavir susceptibility of influenza viruses circulating in the United States during the 2016/17 and 2017/18 seasons. Euro Surveill. 2019;24(3). https://doi.org/10.2807/1560-7917.ES.2019.24.3.1800666 PMID: 30670144
-
World Health Organization. Meetings of the WHO working group on surveillance of influenza antiviral susceptibility – Geneva, November 2011 and June 2012. Wkly Epidemiol Rec. 2012;87(39):369-74. PMID: 23061103
-
Takada K, Kawakami C, Fan S, Chiba S, Zhong G, Gu C, et al. A humanized MDCK cell line for the efficient isolation and propagation of human influenza viruses. Influenza and Other Infections; 2019 February 19-20; Tokyo, Japan.
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Hayden FG, Sugaya N, Hirotsu N, Lee N, de Jong MD, Hurt AC, et al. Baloxavir Marboxil Investigators Group. Baloxavir Marboxil for Uncomplicated Influenza in Adults and Adolescents. N Engl J Med. 2018;379(10):913-23. https://doi.org/10.1056/NEJMoa1716197 PMID: 30184455
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Koszalka P, Tilmanis D, Roe M, Vijaykrishna D, Hurt AC. Baloxavir marboxil susceptibility of influenza viruses from the Asia-Pacific, 2012-2018. Antiviral Res. 2019;164:91-6. https://doi.org/10.1016/j.antiviral.2019.02.007 PMID: 30771405
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National Institute of Infectious Diseases (NIID). Antiviral resistance surveillance in Japan. Tokyo: NIID. Available from: http://www.nih.go.jp/niid/en/influ-resist-e.html
Influenza A(H3N2) virus exhibiting reduced susceptibility to baloxavir due to a polymerase acidic subunit I38T substitution detected from a hospitalised child without prior baloxavir treatment, Japan, January 2019
<p class="citation">
<span>Citation style for this article:</span>
<span class="meta-value authors">
<a href="/search?value1=Emi+Takashita&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Takashita Emi</a>,
<a href="/search?value1=Chiharu+Kawakami&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kawakami Chiharu</a>,
<a href="/search?value1=Rie+Ogawa&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ogawa Rie</a>,
<a href="/search?value1=Hiroko+Morita&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Morita Hiroko</a>,
<a href="/search?value1=Seiichiro+Fujisaki&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fujisaki Seiichiro</a>,
<a href="/search?value1=Masayuki+Shirakura&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Shirakura Masayuki</a>,
<a href="/search?value1=Hideka+Miura&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Miura Hideka</a>,
<a href="/search?value1=Kazuya+Nakamura&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Nakamura Kazuya</a>,
<a href="/search?value1=Noriko+Kishida&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kishida Noriko</a>,
<a href="/search?value1=Tomoko+Kuwahara&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kuwahara Tomoko</a>,
<a href="/search?value1=Akira+Ota&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ota Akira</a>,
<a href="/search?value1=Hayato+Togashi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Togashi Hayato</a>,
<a href="/search?value1=Ayako+Saito&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Saito Ayako</a>,
<a href="/search?value1=Keiko+Mitamura&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mitamura Keiko</a>,
<a href="/search?value1=Takashi+Abe&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Abe Takashi</a>,
<a href="/search?value1=Masataka+Ichikawa&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ichikawa Masataka</a>,
<a href="/search?value1=Masahiko+Yamazaki&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Yamazaki Masahiko</a>,
<a href="/search?value1=Shinji+Watanabe&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Watanabe Shinji</a>,
<a href="/search?value1=Takato+Odagiri&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Odagiri Takato</a></span>.
Influenza A(H3N2) virus exhibiting reduced susceptibility to baloxavir due to a polymerase acidic subunit I38T substitution detected from a hospitalised child without prior baloxavir treatment, Japan, January 2019.
<a href="/content/ecdc">Euro Surveill.</a> 2019;24(12):pii=1900170.
<a href="https://doi.org/10.2807/1560-7917.ES.2019.24.12.1900170" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2019.24.12.1900170</a>
<span class="ES_Article_citation">
<span class="generated">Received</span>: 06 Mar 2019;
<span class="generated">Accepted</span>: 21 Mar 2019
</span>
</p>
/content/10.2807/1560-7917.ES.2019.24.12.1900170
/content/10.2807/1560-7917.ES.2019.24.12.1900170
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