1887
Rapid communication Open Access
Like 0

Abstract

The plasmid-mediated high-level tigecycline resistance gene, (X4), was detected in seven isolates from pork in two Chinese provinces. Two isolates belonged to the epidemic spreading sequence type ST101. (X4) was adjacent to IS and concurrent with in all seven isolates. In addition to IncFIB, the replicon IncFII was found to be linked to (X4). This report follows a recent detection of (X3)/(X4) in from animals and humans in China.

Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2019.24.25.1900340
2019-06-20
2019-07-21
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2019.24.25.1900340
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/24/25/eurosurv-24-25-1.html?itemId=/content/10.2807/1560-7917.ES.2019.24.25.1900340&mimeType=html&fmt=ahah

References

  1. Centers for Disease Control and Prevention. Antibiotic resistance threats in the United States, 2013. Atlanta: CDC; 2013. Available at: http://www.cdc.gov/drugresistance/threat-report-2013/
  2. Schneider ML, Sharma S. China’s Pork Miracle?: Agribusiness and Development in China’s Pork Industry. EUR-ISS-PER; 2014. Available from: https://repub.eur.nl/pub/50768
  3. He T, Wang R, Liu D, Walsh TR, Zhang R, Lv Y, et al. Emergence of plasmid-mediated high-level tigecycline resistance genes in animals and humans. Nat Microbiol. 2019. [Epub ahead of print].  https://doi.org/10.1038/s41564-019-0445-2  PMID: 31133751 
  4. European Committee on Antimicrobial Susceptibility Testing (EUCAST). Clinical breakpoints for bacteria. Växjö: EUCAST. Available from: http://www.eucast.org/clinical_breakpoints/
  5. Liu L, Feng Y, Zhang X, McNally A, Zong Z. New Variant of mcr-3 in an Extensively Drug-Resistant Escherichia coli Clinical Isolate Carrying mcr-1 and blaNDM-5. Antimicrob Agents Chemother. 2017;61(12):e01757-17.  https://doi.org/10.1128/AAC.01757-17  PMID: 28971871 
  6. Li R, Xie M, Zhang J, Yang Z, Liu L, Liu X, et al. Genetic characterization of mcr-1-bearing plasmids to depict molecular mechanisms underlying dissemination of the colistin resistance determinant. J Antimicrob Chemother. 2017;72(2):393-401.  https://doi.org/10.1093/jac/dkw411  PMID: 28073961 
  7. Müller A, Jansen W, Grabowski NT, Monecke S, Ehricht R, Kehrenberg C. ESBL- and AmpC-producing Escherichia coli from legally and illegally imported meat: Characterization of isolates brought into the EU from third countries. Int J Food Microbiol. 2018;283:52-8.  https://doi.org/10.1016/j.ijfoodmicro.2018.06.009  PMID: 30099995 
  8. Toleman MA, Bugert JJ, Nizam SA. Extensively drug-resistant New Delhi metallo-β-lactamase-encoding bacteria in the environment, Dhaka, Bangladesh, 2012. Emerg Infect Dis. 2015;21(6):1027-30.  https://doi.org/10.3201/eid2106.141578  PMID: 25989320 
  9. Ranjan A, Shaik S, Mondal A, Nandanwar N, Hussain A, Semmler T, et al. Molecular Epidemiology and Genome Dynamics of New Delhi Metallo-β-Lactamase-Producing Extraintestinal Pathogenic Escherichia coli Strains from India. Antimicrob Agents Chemother. 2016;60(11):6795-805.  https://doi.org/10.1128/AAC.01345-16  PMID: 27600040 
  10. Didelot X, Walker AS, Peto TE, Crook DW, Wilson DJ. Within-host evolution of bacterial pathogens. Nat Rev Microbiol. 2016;14(3):150-62.  https://doi.org/10.1038/nrmicro.2015.13  PMID: 26806595 
  11. Van Boeckel TP, Brower C, Gilbert M, Grenfell BT, Levin SA, Robinson TP, et al. Global trends in antimicrobial use in food animals. Proc Natl Acad Sci USA. 2015;112(18):5649-54.  https://doi.org/10.1073/pnas.1503141112  PMID: 25792457 
  12. Personal Care Product Market Development Analysis. China Industry Research Net; 2018. Available from: http://www.chinairn.com/report/20180208/093004908.html
  13. Linkevicius M, Sandegren L, Andersson DI. Potential of tetracycline resistance proteins to evolve tigecycline resistance. Antimicrob Agents Chemother. 2016;60(2):789-96.  https://doi.org/10.1128/AAC.02465-15  PMID: 26596936 
/content/10.2807/1560-7917.ES.2019.24.25.1900340
Loading

Data & Media loading...

Supplementary data

Comment has been disabled for this content
Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error