Detection of influenza A(H3N2) viruses exhibiting reduced susceptibility to the novel cap-dependent endonuclease inhibitor baloxavir in Japan, December 2018

Emi Takashita; Chiharu Kawakami; Hiroko Morita; Rie Ogawa; Seiichiro Fujisaki; Masayuki Shirakura; Hideka Miura; Kazuya Nakamura; Noriko Kishida; Tomoko Kuwahara; Keiko Mitamura; Takashi Abe; Masataka Ichikawa; Masahiko Yamazaki; Shinji Watanabe; Takato Odagiri; on behalf of the Influenza Virus Surveillance Group of Japan

doi:10.2807/1560-7917.ES.2019.24.3.1800698

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Detection of influenza A(H3N2) viruses exhibiting reduced susceptibility to the novel cap-dependent endonuclease inhibitor baloxavir in Japan, December 2018
Emi Takashita¹ , Chiharu Kawakami² , Hiroko Morita¹ , Rie Ogawa¹ , Seiichiro Fujisaki¹ , Masayuki Shirakura¹ , Hideka Miura¹ , Kazuya Nakamura¹ , Noriko Kishida¹ , Tomoko Kuwahara¹ , Keiko Mitamura³ , Takashi Abe⁴ , Masataka Ichikawa⁵ , Masahiko Yamazaki⁶ , Shinji Watanabe¹ , Takato Odagiri¹ , on behalf of the Influenza Virus Surveillance Group of Japan⁷
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Affiliations: ¹ Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan ² Yokohama City Institute of Public Health, Kanagawa, Japan ³ Eiju General Hospital, Tokyo, Japan ⁴ Abe Children’s Clinic, Kanagawa, Japan ⁵ Ichikawa Children’s Clinic, Kanagawa, Japan ⁶ Zama Children’s Clinic, Kanagawa, Japan ⁷ The members of the group are listed at the end of the article

Correspondence:
Takato Odagiri
todagiri nih.go.jp
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Citation style for this article: Takashita Emi, Kawakami Chiharu, Morita Hiroko, Ogawa Rie, Fujisaki Seiichiro, Shirakura Masayuki, Miura Hideka, Nakamura Kazuya, Kishida Noriko, Kuwahara Tomoko, Mitamura Keiko, Abe Takashi, Ichikawa Masataka, Yamazaki Masahiko, Watanabe Shinji, Odagiri Takato, on behalf of the Influenza Virus Surveillance Group of Japan. Detection of influenza A(H3N2) viruses exhibiting reduced susceptibility to the novel cap-dependent endonuclease inhibitor baloxavir in Japan, December 2018. Euro Surveill. 2019;24(3):pii=1800698. https://doi.org/10.2807/1560-7917.ES.2019.24.3.1800698 Received: 21 Dec 2018; Accepted: 16 Jan 2019

Abstract

The novel cap-dependent endonuclease inhibitor baloxavir marboxil was approved for the treatment of influenza virus infection in Japan in February 2018. Two influenza A(H3N2) viruses carrying an I38T substitution in the polymerase acidic subunit (PA) were detected in baloxavir-treated children in December 2018. This mutation is known to confer reduced susceptibility to baloxavir, and the two mutant viruses exhibited 76- and 120-fold reduced susceptibility to baloxavir.

This work is licensed under a Creative Commons Attribution 4.0 International License.

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2019-01-17

2025-07-26

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Detection of influenza A(H3N2) viruses exhibiting reduced susceptibility to the novel cap-dependent endonuclease inhibitor baloxavir in Japan, December 2018

Citation style for this article: <a href="/search?value1=Emi+Takashita&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Takashita Emi</a>, <a href="/search?value1=Chiharu+Kawakami&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kawakami Chiharu</a>, <a href="/search?value1=Hiroko+Morita&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Morita Hiroko</a>, <a href="/search?value1=Rie+Ogawa&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ogawa Rie</a>, <a href="/search?value1=Seiichiro+Fujisaki&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fujisaki Seiichiro</a>, <a href="/search?value1=Masayuki+Shirakura&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Shirakura Masayuki</a>, <a href="/search?value1=Hideka+Miura&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Miura Hideka</a>, <a href="/search?value1=Kazuya+Nakamura&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Nakamura Kazuya</a>, <a href="/search?value1=Noriko+Kishida&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kishida Noriko</a>, <a href="/search?value1=Tomoko+Kuwahara&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kuwahara Tomoko</a>, <a href="/search?value1=Keiko+Mitamura&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mitamura Keiko</a>, <a href="/search?value1=Takashi+Abe&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Abe Takashi</a>, <a href="/search?value1=Masataka+Ichikawa&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ichikawa Masataka</a>, <a href="/search?value1=Masahiko+Yamazaki&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Yamazaki Masahiko</a>, <a href="/search?value1=Shinji+Watanabe&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Watanabe Shinji</a>, <a href="/search?value1=Takato+Odagiri&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Odagiri Takato</a>, <a href="/search?value1=on+behalf+of+the+Influenza+Virus+Surveillance+Group+of+Japan&option1=author&noRedirect=true" class="nonDisambigAuthorLink">on behalf of the Influenza Virus Surveillance Group of Japan</a>. Detection of influenza A(H3N2) viruses exhibiting reduced susceptibility to the novel cap-dependent endonuclease inhibitor baloxavir in Japan, December 2018. <a href="/content/ecdc">Euro Surveill.</a> 2019;24(3):pii=1800698. <a href="https://doi.org/10.2807/1560-7917.ES.2019.24.3.1800698" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2019.24.3.1800698</a> Received: 21 Dec 2018;   Accepted: 16 Jan 2019

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Detection of influenza A(H3N2) viruses exhibiting reduced susceptibility to the novel cap-dependent endonuclease inhibitor baloxavir in Japan, December 2018

Abstract

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