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Emergence of enterovirus D68 clade D1, France, August to November 2018
- Antonin Bal1,2,3,4 , Marina Sabatier1,2,3 , Thierry Wirth5,6 , Marianne Coste-Burel7 , Mouna Lazrek8 , Karl Stefic9,10 , Karen Brengel-Pesce4 , Florence Morfin2,3 , Bruno Lina1,2,3 , Isabelle Schuffenecker1,2 , Laurence Josset1,2,3
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View Affiliations Hide AffiliationsAffiliations: 1 Centre National de Référence des Enterovirus et Parechovirus, Hospices Civils de Lyon, Lyon, France 2 Laboratoire de Virologie, Institut des Agents Infectieux, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France 3 Université Lyon 1, Faculté de Médecine Lyon Est, CIRI, Inserm U1111, CNRS UMR5308, Virpath, Lyon, France 4 Laboratoire Commun de Recherche Hospices Civils de Lyon-bioMerieux, Centre Hospitalier Lyon Sud, Pierre-Bénite, France 5 Laboratoire Biologie Intégrative des Populations, Evolution Moléculaire, EPHE, PSL Université, Paris, France 6 Institut Systématique, Evolution, Biodiversité (ISYEB), EPHE, MNHN, CNRS, Sorbonne Université, Paris, France 7 Laboratoire de Virologie, UIC9 CIC infectieux, Centre Hospitalier Universitaire de Nantes, Nantes, France 8 Laboratoire de Virologie, EA3610, Centre Hospitalier Universitaire de Lille, Université de Lille, Lille, France 9 INSERM U1259, Université de Tours, Tours, France 10 Laboratoire de Virologie and CNR VIH-Laboratoire Associé, Centre Hospitalier Régional Universitaire de Tours, Tours, FranceLaurence Jossetlaurence.josset chu-lyon.fr
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Citation style for this article: Bal Antonin, Sabatier Marina, Wirth Thierry, Coste-Burel Marianne, Lazrek Mouna, Stefic Karl, Brengel-Pesce Karen, Morfin Florence, Lina Bruno, Schuffenecker Isabelle, Josset Laurence. Emergence of enterovirus D68 clade D1, France, August to November 2018. Euro Surveill. 2019;24(3):pii=1800699. https://doi.org/10.2807/1560-7917.ES.2019.24.3.1800699 Received: 26 Dec 2018; Accepted: 16 Jan 2019
Abstract
We report a seasonal increase of enterovirus D68 (EV-D68) cases in France, with 54 cases detected between 19 August and 14 November 2018. Molecular typing revealed that 20 of 32 of the isolates belonged to clade D1, only sporadically detected before in France. Median age of D1-cases was 42 years, 10 developed severe respiratory signs and one had neurological complications. The 2018-D1 viruses showed a genetic divergence of 3.34 % with D1 viruses identified previously.

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