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We describe clonal shifts in isolates from clinical samples obtained from patients in Denmark from 2015 to the first quarter (Q1) of 2019. During Q1 2019, the vancomycin-variable enterococci (VVE) ST1421-CT1134 became the most dominant clone and has spread to all five regions in Denmark. Among 174 isolates with or vanA/ genes in Q1 2019, 44% belonged to this type.


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