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Abstract

We identified two new (CT) variants escaping Aptima Combo 2 (AC2) assay detection, in clinical specimens of two patients. One had a C1514T mutation the other a G1523A mutation, both within the AC2 23S rRNA target region. The prevalence of such variants among persons tested for CT in England was estimated to be fewer than 0.003%.

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Addendum for Euro Surveill. 2019;24(38)
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/content/10.2807/1560-7917.ES.2019.24.38.1900557
2019-09-19
2025-07-04
/content/10.2807/1560-7917.ES.2019.24.38.1900557
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Prevalence of new variants of Chlamydia trachomatis escaping detection by the Aptima Combo 2 assay, England, June to August 2019
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=David+J+Roberts&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Roberts David J</a>, <a href="/search?value1=Grahame+S+Davis&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Davis Grahame S</a>, <a href="/search?value1=Michelle+J+Cole&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cole Michelle J</a>, <a href="/search?value1=Dixita+Naik&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Naik Dixita</a>, <a href="/search?value1=Hitiksha+Maru&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Maru Hitiksha</a>, <a href="/search?value1=Neil+Woodford&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Woodford Neil</a>, <a href="/search?value1=Peter+Muir&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Muir Peter</a>, <a href="/search?value1=Paddy+Horner&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Horner Paddy</a>, <a href="/search?value1=Ian+Simms&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Simms Ian</a>, <a href="/search?value1=George+Thickett&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Thickett George</a>, <a href="/search?value1=Paul+Crook&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Crook Paul</a>, <a href="/search?value1=Kirsty+Foster&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Foster Kirsty</a>, <a href="/search?value1=Nick+Andrews&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Andrews Nick</a>, <a href="/search?value1=John+Saunders&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Saunders John</a>, <a href="/search?value1=Helen+Fifer&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fifer Helen</a>, <a href="/search?value1=Kate+Folkard&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Folkard Kate</a>, <a href="/search?value1=O+Noel+Gill&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gill O Noel</a>, <a href="/search?value1=on+behalf+of+the+incident+management+team&option1=author&noRedirect=true" class="nonDisambigAuthorLink">on behalf of the incident management team</a></span>. Prevalence of new variants of Chlamydia trachomatis escaping detection by the Aptima Combo 2 assay, England, June to August 2019. <a href="/content/ecdc">Euro Surveill.</a> 2019;24(38):pii=1900557. <a href="https://doi.org/10.2807/1560-7917.ES.2019.24.38.1900557" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2019.24.38.1900557</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 05 Sept 2019;&nbsp;&nbsp; <span class="generated">Accepted</span>: 19 Sept 2019 </span> </p>
/content/10.2807/1560-7917.ES.2019.24.38.1900557
/content/10.2807/1560-7917.ES.2019.24.38.1900557
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