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Prevalence of new variants of Chlamydia trachomatis escaping detection by the Aptima Combo 2 assay, England, June to August 2019
- David J Roberts1 , Grahame S Davis1 , Michelle J Cole1 , Dixita Naik1 , Hitiksha Maru1 , Neil Woodford1 , Peter Muir2 , Paddy Horner3 , Ian Simms1 , George Thickett1 , Paul Crook4 , Kirsty Foster5 , Nick Andrews6 , John Saunders1 , Helen Fifer1 , Kate Folkard1 , O Noel Gill1 , on behalf of the incident management team7
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View Affiliations Hide AffiliationsAffiliations: 1 National Infection Service, Public Health England, London, United Kingdom 2 South West Regional Public Health Laboratory, Public Health England, Bristol, United Kingdom 3 Population Health Sciences, University of Bristol, Bristol, United Kingdom 4 Field Service South East and London, Public Health England, London, United Kingdom 5 Public Health England North East Centre, Newcastle-upon-Tyne, United Kingdom 6 Statistics, Modelling and Economics Department, Public Health England, London, United Kingdom 7 Members are listed in the acknowledgementsCorrespondence:Ian Simmsian.simms phe.gov.uk
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Citation style for this article: Roberts David J , Davis Grahame S , Cole Michelle J , Naik Dixita , Maru Hitiksha , Woodford Neil , Muir Peter , Horner Paddy , Simms Ian , Thickett George , Crook Paul , Foster Kirsty , Andrews Nick , Saunders John , Fifer Helen , Folkard Kate , Gill O Noel , on behalf of the incident management team . Prevalence of new variants of Chlamydia trachomatis escaping detection by the Aptima Combo 2 assay, England, June to August 2019. Euro Surveill. 2019;24(38):pii=1900557. https://doi.org/10.2807/1560-7917.ES.2019.24.38.1900557 Received: 05 Sep 2019; Accepted: 19 Sep 2019
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Abstract
We identified two new Chlamydia trachomatis (CT) variants escaping Aptima Combo 2 (AC2) assay detection, in clinical specimens of two patients. One had a C1514T mutation the other a G1523A mutation, both within the AC2 23S rRNA target region. The prevalence of such variants among persons tested for CT in England was estimated to be fewer than 0.003%.
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/content/10.2807/1560-7917.ES.2019.24.38.1900557
2019-09-19
2020-07-15
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2019.24.38.1900557
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Prevalence of new variants of Chlamydia trachomatis escaping detection by the Aptima Combo 2 assay, England, June to August 2019
<p class="citation">
<span>Citation style for this article:</span>
<span class="meta-value authors">
<a href="/search?value1=David+J+Roberts&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Roberts David J</a>
,
<a href="/search?value1=Grahame+S+Davis&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Davis Grahame S</a>
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<a href="/search?value1=Michelle+J+Cole&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cole Michelle J</a>
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<a href="/search?value1=Dixita+Naik&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Naik Dixita</a>
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<a href="/search?value1=Hitiksha+Maru&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Maru Hitiksha</a>
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<a href="/search?value1=Neil+Woodford&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Woodford Neil</a>
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<a href="/search?value1=Peter+Muir&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Muir Peter</a>
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<a href="/search?value1=Paddy+Horner&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Horner Paddy</a>
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<a href="/search?value1=Ian+Simms&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Simms Ian</a>
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<a href="/search?value1=George+Thickett&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Thickett George</a>
,
<a href="/search?value1=Paul+Crook&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Crook Paul</a>
,
<a href="/search?value1=Kirsty+Foster&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Foster Kirsty</a>
,
<a href="/search?value1=Nick+Andrews&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Andrews Nick</a>
,
<a href="/search?value1=John+Saunders&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Saunders John</a>
,
<a href="/search?value1=Helen+Fifer&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fifer Helen</a>
,
<a href="/search?value1=Kate+Folkard&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Folkard Kate</a>
,
<a href="/search?value1=O+Noel+Gill&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gill O Noel</a>
,
<a href="/search?value1=on+behalf+of+the+incident+management+team&option1=author&noRedirect=true" class="nonDisambigAuthorLink">on behalf of the incident management team</a>
</span>.
Prevalence of new variants of Chlamydia trachomatis escaping detection by the Aptima Combo 2 assay, England, June to August 2019.
<a href="/content/ecdc">Euro Surveill.</a> 2019;24(38):pii=1900557.
<a href="https://doi.org/10.2807/1560-7917.ES.2019.24.38.1900557" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2019.24.38.1900557</a>
<span class="ES_Article_citation">
<span class="generated">Received</span>: 05 Sep 2019;
<span class="generated">Accepted</span>: 19 Sep 2019
</span>
</p>
/content/10.2807/1560-7917.ES.2019.24.38.1900557
/content/10.2807/1560-7917.ES.2019.24.38.1900557
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