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Prevalence of new variants of Chlamydia trachomatis escaping detection by the Aptima Combo 2 assay, England, June to August 2019
- David J Roberts1 , Grahame S Davis1 , Michelle J Cole1 , Dixita Naik1 , Hitiksha Maru1 , Neil Woodford1 , Peter Muir2 , Paddy Horner3 , Ian Simms1 , George Thickett1 , Paul Crook4 , Kirsty Foster5 , Nick Andrews6 , John Saunders1 , Helen Fifer1 , Kate Folkard1 , O Noel Gill1 , on behalf of the incident management team7
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View Affiliations Hide AffiliationsAffiliations: 1 National Infection Service, Public Health England, London, United Kingdom 2 South West Regional Public Health Laboratory, Public Health England, Bristol, United Kingdom 3 Population Health Sciences, University of Bristol, Bristol, United Kingdom 4 Field Service South East and London, Public Health England, London, United Kingdom 5 Public Health England North East Centre, Newcastle-upon-Tyne, United Kingdom 6 Statistics, Modelling and Economics Department, Public Health England, London, United Kingdom 7 Members are listed in the acknowledgementsCorrespondence:Ian Simmsian.simms phe.gov.uk
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Citation style for this article: Roberts David J, Davis Grahame S, Cole Michelle J, Naik Dixita, Maru Hitiksha, Woodford Neil, Muir Peter, Horner Paddy, Simms Ian, Thickett George, Crook Paul, Foster Kirsty, Andrews Nick, Saunders John, Fifer Helen, Folkard Kate, Gill O Noel, on behalf of the incident management team. Prevalence of new variants of Chlamydia trachomatis escaping detection by the Aptima Combo 2 assay, England, June to August 2019. Euro Surveill. 2019;24(38):pii=1900557. https://doi.org/10.2807/1560-7917.ES.2019.24.38.1900557 Received: 05 Sep 2019; Accepted: 19 Sep 2019
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Abstract
We identified two new Chlamydia trachomatis (CT) variants escaping Aptima Combo 2 (AC2) assay detection, in clinical specimens of two patients. One had a C1514T mutation the other a G1523A mutation, both within the AC2 23S rRNA target region. The prevalence of such variants among persons tested for CT in England was estimated to be fewer than 0.003%.
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/content/10.2807/1560-7917.ES.2019.24.38.1900557
2019-09-19
2022-05-24
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2019.24.38.1900557
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Prevalence of new variants of Chlamydia trachomatis escaping detection by the Aptima Combo 2 assay, England, June to August 2019
<p class="citation">
<span>Citation style for this article:</span>
<span class="meta-value authors">
<a href="/search?value1=David+J+Roberts&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Roberts David J</a>,
<a href="/search?value1=Grahame+S+Davis&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Davis Grahame S</a>,
<a href="/search?value1=Michelle+J+Cole&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cole Michelle J</a>,
<a href="/search?value1=Dixita+Naik&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Naik Dixita</a>,
<a href="/search?value1=Hitiksha+Maru&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Maru Hitiksha</a>,
<a href="/search?value1=Neil+Woodford&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Woodford Neil</a>,
<a href="/search?value1=Peter+Muir&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Muir Peter</a>,
<a href="/search?value1=Paddy+Horner&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Horner Paddy</a>,
<a href="/search?value1=Ian+Simms&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Simms Ian</a>,
<a href="/search?value1=George+Thickett&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Thickett George</a>,
<a href="/search?value1=Paul+Crook&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Crook Paul</a>,
<a href="/search?value1=Kirsty+Foster&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Foster Kirsty</a>,
<a href="/search?value1=Nick+Andrews&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Andrews Nick</a>,
<a href="/search?value1=John+Saunders&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Saunders John</a>,
<a href="/search?value1=Helen+Fifer&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fifer Helen</a>,
<a href="/search?value1=Kate+Folkard&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Folkard Kate</a>,
<a href="/search?value1=O+Noel+Gill&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gill O Noel</a>,
<a href="/search?value1=on+behalf+of+the+incident+management+team&option1=author&noRedirect=true" class="nonDisambigAuthorLink">on behalf of the incident management team</a></span>.
Prevalence of new variants of Chlamydia trachomatis escaping detection by the Aptima Combo 2 assay, England, June to August 2019.
<a href="/content/ecdc">Euro Surveill.</a> 2019;24(38):pii=1900557.
<a href="https://doi.org/10.2807/1560-7917.ES.2019.24.38.1900557" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2019.24.38.1900557</a>
<span class="ES_Article_citation">
<span class="generated">Received</span>: 05 Sep 2019;
<span class="generated">Accepted</span>: 19 Sep 2019
</span>
</p>
/content/10.2807/1560-7917.ES.2019.24.38.1900557
/content/10.2807/1560-7917.ES.2019.24.38.1900557
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