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Abstract

Using a test-negative design, the Canadian Sentinel Practitioner Surveillance Network assessed interim 2018/19 vaccine effectiveness (VE) against predominant influenza A(H1N1)pdm09 viruses. Adjusted VE was 72% (95% confidence interval: 60 to 81) against medically attended, laboratory-confirmed influenza A(H1N1)pdm09 illness. This substantial vaccine protection was observed in all age groups, notably young children who appeared to be disproportionately affected. Sequence analysis identified heterogeneity in emerging clade 6B.1 viruses but no dominant drift variant.

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/content/10.2807/1560-7917.ES.2019.24.4.1900055
2019-01-24
2025-04-23
/content/10.2807/1560-7917.ES.2019.24.4.1900055
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Interim estimates of 2018/19 vaccine effectiveness against influenza A(H1N1)pdm09, Canada, January 2019
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Danuta+M+Skowronski&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Skowronski Danuta M</a>, <a href="/search?value1=Siobhan+Leir&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Leir Siobhan</a>, <a href="/search?value1=Suzana+Sabaiduc&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sabaiduc Suzana</a>, <a href="/search?value1=Michelle+Murti&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Murti Michelle</a>, <a href="/search?value1=James+A+Dickinson&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Dickinson James A</a>, <a href="/search?value1=Romy+Olsha&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Olsha Romy</a>, <a href="/search?value1=Jonathan+B+Gubbay&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gubbay Jonathan B</a>, <a href="/search?value1=Matthew+A+Croxen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Croxen Matthew A</a>, <a href="/search?value1=Hugues+Charest&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Charest Hugues</a>, <a href="/search?value1=Tracy+Chan&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Chan Tracy</a>, <a href="/search?value1=Nathalie+Bastien&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bastien Nathalie</a>, <a href="/search?value1=Yan+Li&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Li Yan</a>, <a href="/search?value1=Mel+Krajden&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Krajden Mel</a>, <a href="/search?value1=Gaston+De+Serres&option1=author&noRedirect=true" class="nonDisambigAuthorLink">De Serres Gaston</a></span>. Interim estimates of 2018/19 vaccine effectiveness against influenza A(H1N1)pdm09, Canada, January 2019. <a href="/content/ecdc">Euro Surveill.</a> 2019;24(4):pii=1900055. <a href="https://doi.org/10.2807/1560-7917.ES.2019.24.4.1900055" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2019.24.4.1900055</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 18 Jan 2019;&nbsp;&nbsp; <span class="generated">Accepted</span>: 24 Jan 2019 </span> </p>
/content/10.2807/1560-7917.ES.2019.24.4.1900055
/content/10.2807/1560-7917.ES.2019.24.4.1900055
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