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Interim estimates of 2018/19 vaccine effectiveness against influenza A(H1N1)pdm09, Canada, January 2019
- Danuta M Skowronski1,2 , Siobhan Leir1 , Suzana Sabaiduc1 , Michelle Murti3,4 , James A Dickinson5 , Romy Olsha3 , Jonathan B Gubbay3,4 , Matthew A Croxen6,7 , Hugues Charest8 , Tracy Chan1 , Nathalie Bastien9 , Yan Li9 , Mel Krajden1,2 , Gaston De Serres8,10,11
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View Affiliations Hide AffiliationsAffiliations: 1 British Columbia Centre for Disease Control, Vancouver, Canada 2 University of British Columbia, Vancouver, Canada 3 Public Health Ontario, Toronto, Canada 4 University of Toronto, Toronto, Canada 5 University of Calgary, Calgary, Canada 6 Provincial Laboratory for Public Health, Edmonton, Canada 7 University of Alberta, Edmonton, Canada 8 Institut National de Santé Publique du Québec, Quebec City, Canada 9 National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada 10 Laval University, Quebec City, Canada 11 Centre Hospitalier Universitaire de Québec, Quebec City, CanadaDanuta M Skowronskidanuta.skowronski bccdc.ca
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Citation style for this article: Skowronski Danuta M, Leir Siobhan, Sabaiduc Suzana, Murti Michelle, Dickinson James A, Olsha Romy, Gubbay Jonathan B, Croxen Matthew A, Charest Hugues, Chan Tracy, Bastien Nathalie, Li Yan, Krajden Mel, De Serres Gaston. Interim estimates of 2018/19 vaccine effectiveness against influenza A(H1N1)pdm09, Canada, January 2019. Euro Surveill. 2019;24(4):pii=1900055. https://doi.org/10.2807/1560-7917.ES.2019.24.4.1900055 Received: 18 Jan 2019; Accepted: 24 Jan 2019
Abstract
Using a test-negative design, the Canadian Sentinel Practitioner Surveillance Network assessed interim 2018/19 vaccine effectiveness (VE) against predominant influenza A(H1N1)pdm09 viruses. Adjusted VE was 72% (95% confidence interval: 60 to 81) against medically attended, laboratory-confirmed influenza A(H1N1)pdm09 illness. This substantial vaccine protection was observed in all age groups, notably young children who appeared to be disproportionately affected. Sequence analysis identified heterogeneity in emerging clade 6B.1 viruses but no dominant drift variant.

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