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Abstract

From June to October 2019, 17 patients (six infected, 11 colonised) with an extensively drug-resistant (XDR) strain were notified from four Western Pomerania medical facilities. The XDR produced carbapenemases NDM-1 and OXA-48, and was only susceptible to chloramphenicol, tigecycline and cefiderocol. Synergistic activity was observed for the combination of aztreonam plus ceftazidime-avibactam. Genomic analyses showed all isolates belonged to sequence type 307. Control measures and further investigations are ongoing.

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/content/10.2807/1560-7917.ES.2019.24.50.1900734
2019-12-12
2020-03-30
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2019.24.50.1900734
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References

  1. Tenover FC, Arbeit RD, Goering RV, Mickelsen PA, Murray BE, Persing DH, et al. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Microbiol. 1995;33(9):2233-9. PMID: 7494007 
  2. Richter M, Rosselló-Móra R, Oliver Glöckner F, Peplies J. JSpeciesWS: a web server for prokaryotic species circumscription based on pairwise genome comparison. Bioinformatics. 2016;32(6):929-31.  https://doi.org/10.1093/bioinformatics/btv681  PMID: 26576653 
  3. Jolley KA, Maiden MC. BIGSdb: Scalable analysis of bacterial genome variation at the population level. BMC Bioinformatics. 2010;11(1):595.  https://doi.org/10.1186/1471-2105-11-595  PMID: 21143983 
  4. Wick RR, Heinz E, Holt KE, Wyres KL. Kaptive Web: User-Friendly Capsule and Lipopolysaccharide Serotype Prediction for Klebsiella Genomes. J Clin Microbiol. 2018;56(6):e00197-18.  https://doi.org/10.1128/JCM.00197-18  PMID: 29618504 
  5. Wyres KL, Wick RR, Gorrie C, Jenney A, Follador R, Thomson NR, et al. Identification of Klebsiella capsule synthesis loci from whole genome data. Microb Genom. 2016;2(12):e000102.  https://doi.org/10.1099/mgen.0.000102  PMID: 28348840 
  6. Zankari E, Hasman H, Cosentino S, Vestergaard M, Rasmussen S, Lund O, et al. Identification of acquired antimicrobial resistance genes. J Antimicrob Chemother. 2012;67(11):2640-4.  https://doi.org/10.1093/jac/dks261  PMID: 22782487 
  7. Novović K, Trudić A, Brkić S, Vasiljević Z, Kojić M, Medić D, et al. Molecular Epidemiology of Colistin-Resistant, Carbapenemase-Producing Klebsiella pneumoniae in Serbia from 2013 to 2016. Antimicrob Agents Chemother. 2017;61(5):e02550-16.  https://doi.org/10.1128/AAC.02550-16  PMID: 28242665 
  8. European Centre for Disease Prevention and Control (ECDC). Outbreak of carbapenemase-producing (NDM-1 and OXA-48) and colistin-resistant Klebsiella pneumoniae ST307, north-east Germany, 2019. Stockholm: ECDC; 2019. Available from: https://www.ecdc.europa.eu/en/publications-data/outbreak-Klebsiella-pneumoniae-Germany
  9. Robert Koch Institute (RKI). Information zum Auftreten von Klebsiella pneumoniae mit OXA-48 und NDM-1 Carbapenemasenund Colistinresistenz in Mecklenburg-Vorpommern. [Information on the occurrence of Klebsiella pneumoniae with OXA-48 and NDM-1 carbapenemase and colistin resistance in Mecklenburg-Western Pomerania]. Epidemiologisches Bulletin. 2 October 2019. Available from: https://www.rki.de/DE/Content/Infekt/EpidBull/Archiv/2019/40/Art_02.html
  10. Abu Sin M, Blank H-P, Eckmanns T, Haller S. Die Bedeutung von Screeninguntersuchungen bei nosokomialen Ausbrüchen aus epidemiologischer Perspektive. Hyg Med. 2016;41:D32-7.
  11. Friedrich AW, Daniels-Haardt I, Köck R, Verhoeven F, Mellmann A, Harmsen D, et al. EUREGIO MRSA-net Twente/Münsterland--a Dutch-German cross-border network for the prevention and control of infections caused by methicillin-resistant Staphylococcus aureus. Euro Surveill. 2008;13(35):13.  https://doi.org/10.2807/ese.13.35.18965-en  PMID: 18761882 
  12. Guducuoglu H, Gursoy NC, Yakupogullari Y, Parlak M, Karasin G, Sunnetcioglu M, et al. Hospital Outbreak of a Colistin-Resistant, NDM-1- and OXA-48-Producing Klebsiella pneumoniae: High Mortality from Pandrug Resistance. Microb Drug Resist. 2018;24(7):966-72.  https://doi.org/10.1089/mdr.2017.0173  PMID: 29265963 
  13. Pirš M, Cerar Kišek T, Križan Hergouth V, Seme K, Mueller Premru M, Jeverica S, et al. Successful control of the first OXA-48 and/or NDM carbapenemase-producing Klebsiella pneumoniae outbreak in Slovenia 2014-2016. J Hosp Infect. 2019;101(2):142-9.  https://doi.org/10.1016/j.jhin.2018.10.022  PMID: 30399389 
  14. Gona F, Bongiorno D, Aprile A, Corazza E, Pasqua B, Scuderi MG, et al. Emergence of two novel sequence types (3366 and 3367) NDM-1- and OXA-48-co-producing K. pneumoniae in Italy. Eur J Clin Microbiol Infect Dis. 2019;38(9):1687-91.  https://doi.org/10.1007/s10096-019-03597-w  PMID: 31165962 
  15. Seiffert SN, Marschall J, Perreten V, Carattoli A, Furrer H, Endimiani A. Emergence of Klebsiella pneumoniae co-producing NDM-1, OXA-48, CTX-M-15, CMY-16, QnrA and ArmA in Switzerland. Int J Antimicrob Agents. 2014;44(3):260-2.  https://doi.org/10.1016/j.ijantimicag.2014.05.008  PMID: 25123809 
  16. Xie L, Dou Y, Zhou K, Chen Y, Han L, Guo X, et al. Coexistence of blaOXA-48 and Truncated blaNDM-1 on Different Plasmids in a Klebsiella pneumoniae Isolate in China. Front Microbiol. 2017;8:133.  https://doi.org/10.3389/fmicb.2017.00133  PMID: 28210248 
  17. Wyres KL, Hawkey J, Hetland MAK, Fostervold A, Wick RR, Judd LM, et al. Emergence and rapid global dissemination of CTX-M-15-associated Klebsiella pneumoniae strain ST307. J Antimicrob Chemother. 2019;74(3):577-81.  https://doi.org/10.1093/jac/dky492  PMID: 30517666 
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