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Surveillance Open Access
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Abstract

Introduction

Haemolytic uraemic syndrome (HUS) related to Shiga toxin-producing (STEC) is the leading cause of acute renal failure in young children. In France, HUS surveillance in children aged < 15 years was implemented starting from 1996.

Aim

We present the results of this surveillance between 2007 and 2016.

Methods

A voluntary nationwide network of 32 paediatric departments notifies cases. Two national reference centres perform microbiological STEC confirmation.

Results

Over the study period, the paediatric HUS incidence rate (IR) was 1.0 per 100,000 children-years, with a median of 116 cases/year. In 2011, IR peaked at 1.3 per 100,000 children-years, and decreased to 1.0 per 100,000 children-years in 2016. STEC O157 associated HUS peaked at 37 cases in 2011 and decreased to seven cases in 2016. Cases of STEC O26-associated HUS have increased since 2010 and STEC O80 associated HUS has emerged since 2012, with 28 and 18 cases respectively reported in 2016. Four STEC-HUS food-borne outbreaks were detected (three STEC O157 linked to ground beef and raw-milk cheese and one STEC O104 linked to fenugreek sprouts). In addition, two outbreaks related to person-to-person transmission occurred in distinct kindergartens (STEC O111 and O26).

Conclusions

No major changes in HUS IRs were observed over the study period of 10 years. However, changes in the STEC serogroups over time and the outbreaks detected argue for continuing epidemiological and microbiological surveillance.

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/content/10.2807/1560-7917.ES.2019.24.8.1800068
2019-02-21
2019-10-17
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2019.24.8.1800068
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References

  1. Tarr PI, Gordon CA, Chandler WL. Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome. Lancet. 2005;365(9464):1073-86.  https://doi.org/10.1016/S0140-6736(05)71144-2  PMID: 15781103 
  2. Rosales A, Hofer J, Zimmerhackl LB, Jungraithmayr TC, Riedl M, Giner T, et al. Need for long-term follow-up in enterohemorrhagic Escherichia coli-associated hemolytic uremic syndrome due to late-emerging sequelae. Clin Infect Dis. 2012;54(10):1413-21.  https://doi.org/10.1093/cid/cis196  PMID: 22412065 
  3. Ferens WA, Hovde CJ. Escherichia coli O157:H7: animal reservoir and sources of human infection. Foodborne Pathog Dis. 2011;8(4):465-87.  https://doi.org/10.1089/fpd.2010.0673  PMID: 21117940 
  4. Bibbal D, Loukiadis E, Kérourédan M, Ferré F, Dilasser F, Peytavin de Garam C, et al. Prevalence of carriage of Shiga toxin-producing Escherichia coli serotypes O157:H7, O26:H11, O103:H2, O111:H8, and O145:H28 among slaughtered adult cattle in France. Appl Environ Microbiol. 2015;81(4):1397-405.  https://doi.org/10.1128/AEM.03315-14  PMID: 25527532 
  5. Kintz E, Brainard J, Hooper L, Hunter P. Transmission pathways for sporadic Shiga-toxin producing E. coli infections: A systematic review and meta-analysis. Int J Hyg Environ Health. 2017;220(1):57-67.  https://doi.org/10.1016/j.ijheh.2016.10.011  PMID: 27842895 
  6. Vaillant V, Espié E, de Valk H, Durr U, Barataud D, Bouvet P, et al. Undercooked ground beef and person-to-person transmission as major risk factors for sporadic hemolytic uremic syndrome related to Shiga-toxin producing Escherchia coli infections in children in France. Pediatr Infect Dis J. 2009;28(7):650-3.  https://doi.org/10.1097/INF.0b013e3181993731  PMID: 19483660 
  7. Tuttle J, Gomez T, Doyle MP, Wells JG, Zhao T, Tauxe RV, et al. Lessons from a large outbreak of Escherichia coli O157:H7 infections: insights into the infectious dose and method of widespread contamination of hamburger patties. Epidemiol Infect. 1999;122(2):185-92.  https://doi.org/10.1017/S0950268898001976  PMID: 10355781 
  8. Majowicz SE, Scallan E, Jones-Bitton A, Sargeant JM, Stapleton J, Angulo FJ, et al. Global incidence of human Shiga toxin-producing Escherichia coli infections and deaths: a systematic review and knowledge synthesis. Foodborne Pathog Dis. 2014;11(6):447-55.  https://doi.org/10.1089/fpd.2013.1704  PMID: 24750096 
  9. Bruyand M, Mariani-Kurkdjian P, Gouali M, de Valk H, King LA, Le Hello S, et al. Hemolytic uremic syndrome due to Shiga toxin-producing Escherichia coli infection. Med Mal Infect. 2018;48(3):167-74.  https://doi.org/10.1016/j.medmal.2017.09.012  PMID: 29054297 
  10. Sodha SV, Heiman K, Gould LH, Bishop R, Iwamoto M, Swerdlow DL, et al. National patterns of Escherichia coli O157 infections, USA, 1996-2011. Epidemiol Infect. 2015;143(2):267-73.  https://doi.org/10.1017/S0950268814000880  PMID: 24731294 
  11. Ong KL, Apostal M, Comstock N, Hurd S, Webb TH, Mickelson S, et al. Strategies for surveillance of pediatric hemolytic uremic syndrome: Foodborne Diseases Active Surveillance Network (FoodNet), 2000-2007. Clin Infect Dis. 2012;54(Suppl 5):S424-31.  https://doi.org/10.1093/cid/cis208  PMID: 22572665 
  12. European Food Safety Authority (EFSA) and European Centre for Disease Control and Prevention (ECDC). The European Union summary report on trends and sources of zoonoses, zoonotic agents and food-borne outbreaks in 2015. Parma and Stockholm: EFSA and ECDC; 2016. Available from: http://ecdc.europa.eu/en/publications/Publications/EU-summary-report-trends-sources-zoonoses-2015.pdf
  13. Espié E, Grimont F, Mariani-Kurkdjian P, Bouvet P, Haeghebaert S, Filliol I, et al. Surveillance of hemolytic uremic syndrome in children less than 15 years of age, a system to monitor O157 and non-O157 Shiga toxin-producing Escherichia coli infections in France, 1996-2006. Pediatr Infect Dis J. 2008;27(7):595-601.  https://doi.org/10.1097/INF.0b013e31816a062f  PMID: 18520972 
  14. Bruyand M, Mariani-Kurkdjian P, Bonacorsi S, Gouali M, Le Hello S, Van Cauteren D, et al. Surveillance du syndrome hémolytique et urémique post-diarrhéique chez l'enfant de moins de 15 ans en France en 2015. [Surveillance of hemolytic and uremic post-diarrheal syndrome in children under 15 years in France in 2015]. Saint-Maurice: Santé publique France [Public Health France]; 2018. French. Available from: http://www.invs.sante.fr/Dossiers-thematiques/Maladies-infectieuses/Risques-infectieux-d-origine-alimentaire/Syndrome-hemolytique-et-uremique/Donnees-epidemiologiques-du-SHU-chez-l-enfant-age-de-moins-de-15-ans-en-France
  15. Institut Pasteur. Centre National de Référence des Escherichia coli, Shigella et Salmonella. Paris: Institut Pasteur. [Accessed 1 Nov 2018]. Available from: https://www.pasteur.fr/fr/sante-publique/CNR/les-cnr/escherichia-coli-shigella-salmonella
  16. Machado J, Grimont F, Grimont PA. Identification of Escherichia coli flagellar types by restriction of the amplified fliC gene. Res Microbiol. 2000;151(7):535-46.  https://doi.org/10.1016/S0923-2508(00)00223-0  PMID: 11037131 
  17. Coimbra RS, Grimont F, Lenormand P, Burguière P, Beutin L, Grimont PA. Identification of Escherichia coli O-serogroups by restriction of the amplified O-antigen gene cluster (rfb-RFLP). Res Microbiol. 2000;151(8):639-54.  https://doi.org/10.1016/S0923-2508(00)00134-0  PMID: 11081579 
  18. International Organization for Standardization (ISO). ISO/TS 13136:2012. Microbiology of food and animal feed. Real‐time polymerase chain reaction (PCR)‐based method for the detection of food‐borne pathogens. Horizontal method for the detection of shiga toxin producing Escherichia coli (STEC) and the determination of O157, O111, O26, O103 and O145 serogroups. Geneva: ISO; 2012.
  19. King LA, Nogareda F, Weill FX, Mariani-Kurkdjian P, Loukiadis E, Gault G, et al. Outbreak of Shiga toxin-producing Escherichia coli O104:H4 associated with organic fenugreek sprouts, France, June 2011. Clin Infect Dis. 2012;54(11):1588-94.  https://doi.org/10.1093/cid/cis255  PMID: 22460976 
  20. Frank C, Werber D, Cramer JP, Askar M, Faber M, an der Heiden M, et al. Epidemic profile of Shiga-toxin-producing Escherichia coli O104:H4 outbreak in Germany. N Engl J Med. 2011;365(19):1771-80.  https://doi.org/10.1056/NEJMoa1106483  PMID: 21696328 
  21. Ribot EM, Fair MA, Gautom R, Cameron DN, Hunter SB, Swaminathan B, et al. Standardization of pulsed-field gel electrophoresis protocols for the subtyping of Escherichia coli O157:H7, Salmonella, and Shigella for PulseNet. Foodborne Pathog Dis. 2006;3(1):59-67.  https://doi.org/10.1089/fpd.2006.3.59  PMID: 16602980 
  22. Institut national de la statistique et des études économiques (Insee). [Accessed 11 Nov 2018]. Available from: https://www.insee.fr/fr/accueil
  23. Santé publique France [Public Health France]. Episode de cas groupés de syndromes hémolytiques et urémiques (SHU) et de diarrhées sanglantes survenus dans le Sud-Ouest, Juin 2012. Bilan au 18 juillet 2012. [Episode of group cases of haemolytic and uremic syndromes (HUS) and bloody diarrhea occurring in the South-West, June 2012. Update on July 18, 2012]. Saint-Maurice: Santé publique France; 2012. Available from: http://invs.santepubliquefrance.fr/Dossiers-thematiques/Maladies-infectieuses/Risques-infectieux-d-origine-alimentaire/Syndrome-hemolytique-et-uremique/Actualites/Archives/Episode-de-cas-groupes-de-syndromes-hemolytiques-et-uremiques-SHU-et-de-diarrhees-sanglantes-survenus-dans-le-Sud-Ouest-Juin-2012.-Bilan-au-18-juillet-2012. Accessed on 11/01/2018.
  24. King LA, Loukiadis E, Mariani-Kurkdjian P, Haeghebaert S, Weill FX, Baliere C, et al. Foodborne transmission of sorbitol-fermenting Escherichia coli O157:[H7] via ground beef: an outbreak in northern France, 2011. Clin Microbiol Infect. 2014;20(12):O1136-44.  https://doi.org/10.1111/1469-0691.12736  PMID: 24962059 
  25. Haut Conseil de la Santé Publique. [High Council of Public Health]. Gastroentérites à Escherichia coli entérohémorragique. [Enterohaemorrhagic Escherichia coli gastroenteritis]. [Accessed 11 Nov 2018]. Available from: http://www.hcsp.fr/Explore.cgi/avisrapportsdomaine?clefr=494
  26. King LA, Mailles A, Mariani-Kurkdjian P, Vernozy-Rozand C, Montet MP, Grimont F, et al. Community-wide outbreak of Escherichia coli O157:H7 associated with consumption of frozen beef burgers. Epidemiol Infect. 2009;137(6):889-96.  https://doi.org/10.1017/S0950268808001490  PMID: 18945376 
  27. Ministère de l'agriculture et de l'alimentation [Ministery of Agriculture and Food]. Production de viandes hachées et préparations de viande dans les établissements agréés ou dérogataires à l’agrément. [Production of minced meat and meat preparations in establishments approved or derogated from approval]. [Accessed 11 Nov 2018]. French. Available from: https://info.agriculture.gouv.fr/gedei/site/bo-agri/instruction-2015-507
  28. Soysal N, Mariani-Kurkdjian P, Smail Y, Liguori S, Gouali M, Loukiadis E, et al. Enterohemorrhagic Escherichia coli Hybrid Pathotype O80:H2 as a New Therapeutic Challenge. Emerg Infect Dis. 2016;22(9):1604-12.  https://doi.org/10.3201/eid2209.160304  PMID: 27533474 
  29. Gould LH, Bopp C, Strockbine N, Atkinson R, Baselski V, Body B, et al. Recommendations for diagnosis of shiga toxin--producing Escherichia coli infections by clinical laboratories. MMWR Recomm Rep. 2009;58(RR-12):1-14. PMID: 19834454 
  30. Holmes A, Allison L, Ward M, Dallman TJ, Clark R, Fawkes A, et al. Utility of Whole-Genome Sequencing of Escherichia coli O157 for Outbreak Detection and Epidemiological Surveillance. J Clin Microbiol. 2015;53(11):3565-73.  https://doi.org/10.1128/JCM.01066-15  PMID: 26354815 
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