- Mathias Bruyand1, Patricia Mariani-Kurkdjian2, Simon Le Hello3, Lisa-A King4, Dieter Van Cauteren1, Sophie Lefevre3, Malika Gouali3, Nathalie Jourdan-da Silva1, Alexandra Mailles1, Marie-Pierre Donguy5, Estelle Loukiadis6,7, Delphine Sergentet-Thevenot6,7, Chantal Loirat8, Stéphane Bonacorsi2, François-Xavier Weill3, Henriette De Valk1, Réseau français hospitalier de surveillance du SHU pédiatrique9
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View Affiliations Hide AffiliationsAffiliations: 1 Santé publique France, Saint Maurice, France 2 Service de Microbiologie, Hôpital Robert-Debré, AP-HP, Paris, France 3 Institut Pasteur, Unité des Bactéries Pathogènes Entériques, Centre National de Référence des E. coli, Shigella et Salmonella, Paris, France 4 Santé publique France, Rennes, France 5 Ministry of Agriculture, Agrifood, and Forestry, Paris, France 6 Université de Lyon, VetAgro Sup, Laboratoire National de Référence pour les Escherichia coli, Marcy l’Etoile, France 7 Université de Lyon, CNRS, INRA, Université Claude Bernard Lyon 1, VetAgro Sup, Laboratoire d’Ecologie Microbienne, Villeurbanne, France 8 Pediatric Nephrology Department, University Hospital Robert Debré, Paris, France 9 Members of the Réseau français hospitalier de surveillance du SHU pédiatrique have been listed at the end of the articleMathias Bruyandmathias.bruyand santepubliquefrance.fr
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Citation style for this article: Bruyand Mathias, Mariani-Kurkdjian Patricia, Le Hello Simon, King Lisa-A, Van Cauteren Dieter, Lefevre Sophie, Gouali Malika, Jourdan-da Silva Nathalie, Mailles Alexandra, Donguy Marie-Pierre, Loukiadis Estelle, Sergentet-Thevenot Delphine, Loirat Chantal, Bonacorsi Stéphane, Weill François-Xavier, De Valk Henriette, Réseau français hospitalier de surveillance du SHU pédiatrique. Paediatric haemolytic uraemic syndrome related to Shiga toxin-producing Escherichia coli, an overview of 10 years of surveillance in France, 2007 to 2016. Euro Surveill. 2019;24(8):pii=1800068. https://doi.org/10.2807/1560-7917.ES.2019.24.8.1800068 Received: 09 Feb 2018; Accepted: 31 Dec 2018
Paediatric haemolytic uraemic syndrome related to Shiga toxin-producing Escherichia coli, an overview of 10 years of surveillance in France, 2007 to 2016
Abstract
Haemolytic uraemic syndrome (HUS) related to Shiga toxin-producing Escherichia coli (STEC) is the leading cause of acute renal failure in young children. In France, HUS surveillance in children aged < 15 years was implemented starting from 1996.
We present the results of this surveillance between 2007 and 2016.
A voluntary nationwide network of 32 paediatric departments notifies cases. Two national reference centres perform microbiological STEC confirmation.
Over the study period, the paediatric HUS incidence rate (IR) was 1.0 per 100,000 children-years, with a median of 116 cases/year. In 2011, IR peaked at 1.3 per 100,000 children-years, and decreased to 1.0 per 100,000 children-years in 2016. STEC O157 associated HUS peaked at 37 cases in 2011 and decreased to seven cases in 2016. Cases of STEC O26-associated HUS have increased since 2010 and STEC O80 associated HUS has emerged since 2012, with 28 and 18 cases respectively reported in 2016. Four STEC-HUS food-borne outbreaks were detected (three STEC O157 linked to ground beef and raw-milk cheese and one STEC O104 linked to fenugreek sprouts). In addition, two outbreaks related to person-to-person transmission occurred in distinct kindergartens (STEC O111 and O26).
No major changes in HUS IRs were observed over the study period of 10 years. However, changes in the STEC serogroups over time and the outbreaks detected argue for continuing epidemiological and microbiological surveillance.

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