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Abstract

Introduction

Lymphogranuloma venereum (LGV), an invasive form of infection, has been reported among (mainly HIV-positive) men who have sex with men (MSM) since 2003. In the Netherlands, LGV testing recommendations changed from selective to universal testing in 2015. Changes in tested populations could have led to incomparable LGV positivity rates over time.

Aim

We investigated LGV trends among MSM attending Centres for Sexual Health using surveillance data between 2011 and 2017.

Methods

LGV positivity was calculated among MSM tested for rectal infection and MSM tested specifically for LGV. With multivariable logistic regression analysis, the association between years and LGV was adjusted for testing indicators and determinants.

Results

We included 224,194 consultations. LGV increased from 86 in 2011 to 270 in 2017. Among LGV-positives, proportions of HIV-negative and asymptomatic MSM increased from 17.4% to 45.6% and from 31.4% to 49.3%, respectively, between 2011 and 2017. Among MSM tested for rectal chlamydia, LGV positivity increased from 0.12% to 0.33% among HIV-negatives and remained stable around 2.5% among HIV-positives. Among LGV-tested MSM, LGV positivity increased from 2.1% to 5.7% among HIV-negatives and from 15.1% to 22.1% among HIV-positives. Multivariable models showed increased odds ratios and significant positive associations between years and LGV.

Conclusions

Although increased testing and changes in LGV incidence are difficult to disentangle, we found increasing LGV trends, especially when corrected for confounding. LGV was increasingly attributed to HIV-negative and asymptomatic MSM, among whom testing was previously limited. This stresses the importance of universal testing and continuous surveillance.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
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/content/10.2807/1560-7917.ES.2020.25.14.1900377
2020-04-09
2024-04-27
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2020.25.14.1900377
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Increasing trends of lymphogranuloma venereum among HIV-negative and asymptomatic men who have sex with men, the Netherlands, 2011 to 2017
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Fleur+van+Aar&option1=author&noRedirect=true" class="nonDisambigAuthorLink">van Aar Fleur</a>, <a href="/search?value1=Michelle+M+Kroone&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kroone Michelle M</a>, <a href="/search?value1=Henry+JC+de+Vries&option1=author&noRedirect=true" class="nonDisambigAuthorLink">de Vries Henry JC</a>, <a href="/search?value1=Hannelore+M+G%C3%B6tz&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Götz Hannelore M</a>, <a href="/search?value1=Birgit+HB+van+Benthem&option1=author&noRedirect=true" class="nonDisambigAuthorLink">van Benthem Birgit HB</a></span>. Increasing trends of lymphogranuloma venereum among HIV-negative and asymptomatic men who have sex with men, the Netherlands, 2011 to 2017. <a href="/content/ecdc">Euro Surveill.</a> 2020;25(14):pii=1900377. <a href="https://doi.org/10.2807/1560-7917.ES.2020.25.14.1900377" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2020.25.14.1900377</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 11 Jun 2019;&nbsp;&nbsp; <span class="generated">Accepted</span>: 03 Feb 2020 </span> </p>
/content/10.2807/1560-7917.ES.2020.25.14.1900377
/content/10.2807/1560-7917.ES.2020.25.14.1900377
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