1887
Rapid communication Open Access
Like 0

Abstract

We describe clinical characteristics, treatments and outcomes of 44 Caucasian patients with coronavirus disease (COVID-19) at a single hospital in Pavia, Italy, from 21–28 February 2020, at the beginning of the outbreak in Europe. Seventeen patients developed severe disease, two died. After a median of 6 days, 14 patients were discharged from hospital. Predictors of lower odds of discharge were age > 65 years, antiviral treatment and for severe disease, lactate dehydrogenase > 300 mg/dL.

Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2020.25.16.2000460
2020-04-23
2024-12-14
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2020.25.16.2000460
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/25/16/eurosurv-25-16-2.html?itemId=/content/10.2807/1560-7917.ES.2020.25.16.2000460&mimeType=html&fmt=ahah

References

  1. World Health Organization (WHO). WHO Director-General’s opening remarks at the media briefing on COVID-19 - 11 March 2020. Geneva: WHO. 11 Mar 2020. Available from: https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19---11-march-2020
  2. Johns Hopkins University & Medicine. Coronavirus Resource Center. Coronavirus COVID-19 Global Cases by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU). Baltimore: Johns Hopkins University & Medicine. [Accessed: 20 Apr 2020]. Available from: https://coronavirus.jhu.edu/map.html
  3. Xu X-W, Wu X-X, Jiang X-G, Xu K-J, Ying L-J, Ma C-L, et al. Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series. BMJ. 2020;368:m606.  https://doi.org/10.1136/bmj.m606  PMID: 32075786 
  4. Wu J, Liu J, Zhao X, Liu C, Wang W, Wang D, et al. Clinical Characteristics of Imported Cases of COVID-19 in Jiangsu Province: A Multicenter Descriptive Study. Clin Infect Dis. 2020. PMID: 32109279 
  5. Guan W-J, Ni Z-Y, Hu Y, Liang W-H, Ou C-Q, He J-X, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020. PMID: 32109013 
  6. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506.  https://doi.org/10.1016/S0140-6736(20)30183-5  PMID: 31986264 
  7. Corman VM, Landt O, Kaiser M, Molenkamp R, Meijer A, Chu DK, et al. Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR. Euro Surveill. 2020;25(3).  https://doi.org/10.2807/1560-7917.ES.2020.25.3.2000045  PMID: 31992387 
  8. Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395(10223):507-13.  https://doi.org/10.1016/S0140-6736(20)30211-7  PMID: 32007143 
  9. Novel Coronavirus Pneumonia Emergency Response Epidemiology Team. [The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China]. Zhonghua Liu Xing Bing Xue Za Zhi. 2020;41(2):145-51. PMID: 32064853 
  10. Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020;323(11):1061.  https://doi.org/10.1001/jama.2020.1585  PMID: 32031570 
  11. Cao B, Wang Y, Wen D, Liu W, Wang J, Fan G, et al. A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19. N Engl J Med. 2020; . PMID: 32187464 
  12. United States National Library of Medicine. Adaptive COVID-19 Treatment Trial (ACTT). Bethesda (MD): US National Library of Medicine. 2020. [Accessed: 23 Apr 2020]. Available from: https://clinicaltrials.gov/ct2/show/NCT04280705
  13. Cheng S-C, Chang Y-C, Fan Chiang Y-L, Chien Y-C, Cheng M, Yang C-H, et al. First case of Coronavirus Disease 2019 (COVID-19) pneumonia in Taiwan. J Formos Med Assoc. 2020;119(3):747-51.  https://doi.org/10.1016/j.jfma.2020.02.007  PMID: 32113824 
  14. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506.  https://doi.org/10.1016/S0140-6736(20)30183-5  PMID: 31986264 
  15. Al Ghamdi M, Alghamdi KM, Ghandoora Y, Alzahrani A, Salah F, Alsulami A, et al. Treatment outcomes for patients with Middle Eastern Respiratory Syndrome Coronavirus (MERS CoV) infection at a coronavirus referral center in the Kingdom of Saudi Arabia. BMC Infect Dis. 2016;16(1):174.  https://doi.org/10.1186/s12879-016-1492-4  PMID: 27097824 
  16. Vogel M, Weissgerber P, Goeppert B, Hetzel J, Vatlach M, Claussen C, et al. Accuracy of serum LDH elevation for the diagnosis of Pneumocystis jiroveci pneumonia. Swiss Med Wkly. 2011;141:w13184.  https://doi.org/10.4414/smw.2011.13184  PMID: 21528464 
  17. Tsui PT, Kwok ML, Yuen H, Lai ST. Severe acute respiratory syndrome: clinical outcome and prognostic correlates. Emerg Infect Dis. 2003;9(9):1064-9.  https://doi.org/10.3201/eid0909.030362  PMID: 14519241 
  18. Li YX, Wu W, Yang T, Zhou W, Fu YM, Feng QM, et al. [Characteristics of peripheral blood leukocyte differential counts in patients with COVID-19]. Zhonghua Nei Ke Za Zhi. 2020;59(0):E003. PMID: 32114745 
  19. Zhang J-J, Dong X, Cao Y-Y, Yuan Y-D, Yang Y-B, Yan Y-Q, et al. Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China. Allergy. 2020. PMID: 32077115 
  20. Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020;323(11):1061.  https://doi.org/10.1001/jama.2020.1585  PMID: 32031570 
  21. Guo L, Wei D, Zhang X, Wu Y, Li Q, Zhou M, et al. Clinical Features Predicting Mortality Risk in Patients With Viral Pneumonia: The MuLBSTA Score. Front Microbiol. 2019;10:2752. . Available from: https://pubmed.ncbi.nlm.nih.gov/31849894 https://doi.org/10.3389/fmicb.2019.02752  PMID: 31849894 
  22. Sun P, Qie S, Liu Z, Ren J, Li K, Xi J. Clinical characteristics of 50466 hospitalized patients with 2019-nCoV infection. J Med Virol. 2020.  PMID: 32108351 
  23. Zhang H, Kang Z, Gong H, Xu D, Wang J, Li Z, et al. The digestive system is a potential route of 2019-nCov infection: a bioinformatics analysis based on single-cell transcriptomes. bioRxiv. 2020. Available from: http://biorxiv.org/content/early/2020/01/31/2020.01.30.927806
  24. Leung WK, To K-F, Chan PKS, Chan HLY, Wu AKL, Lee N, et al. Enteric involvement of severe acute respiratory syndrome-associated coronavirus infection. Gastroenterology. 2003;125(4):1011-7.  https://doi.org/10.1016/j.gastro.2003.08.001  PMID: 14517783 
/content/10.2807/1560-7917.ES.2020.25.16.2000460
Loading

Data & Media loading...

Supplementary data

Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error