1887
Rapid communication Open Access
Like 1

Abstract

Analysis of sequencing data for 143 - and -positive isolates from 13 European national collections and the public domain resulted in the identification of 15 previously undetected multi-country transmission clusters. For 10 clusters, cases had prior travel/hospitalisation history in countries outside of the European Union including Egypt, Iran, Morocco, Russia, Serbia, Tunisia and Turkey. These findings highlight the benefit of European whole genome sequencing-based surveillance and data sharing for control of antimicrobial resistance.

Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2020.25.20.2000627
2020-05-21
2020-09-18
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2020.25.20.2000627
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/25/20/eurosurv-25-20-2.html?itemId=/content/10.2807/1560-7917.ES.2020.25.20.2000627&mimeType=html&fmt=ahah

References

  1. European Centre for Disease Prevention and Control (ECDC). Rapid risk assessment: Outbreak of carbapenemase-producing (NDM-1 and OXA-48) and colistin-resistant Klebsiella pneumoniae ST307, north-east Germany, 2019. Stockholm: ECDC; 2019. Available from: https://www.ecdc.europa.eu/sites/default/files/documents/Klebsiella-pneumoniae-resistance-Germany-risk-assessment.pdf
  2. Haller S, Kramer R, Becker K, Bohnert JA, Eckmanns T, Hans JB, et al. Extensively drug-resistant Klebsiella pneumoniae ST307 outbreak, north-eastern Germany, June to October 2019. Euro Surveill. 2019;24(50):1900734.  https://doi.org/10.2807/1560-7917.ES.2019.24.50.1900734  PMID: 31847948 
  3. Kumar N, Raven KE, Blane B, Leek D, Brown NM, Bragin E, et al. Evaluation of a fully automated bioinformatics tool to predict antibiotic resistance from MRSA genomes. J Antimicrob Chemother. 2020;75(5):1117-22.  https://doi.org/10.1093/jac/dkz570  PMID: 32025709 
  4. Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees. Heidelberg: EMBL. [Accessed: 7 May 2020]. Available from: https://itol.embl.de/
  5. Zankari E, Hasman H, Cosentino S, Vestergaard M, Rasmussen S, Lund O, et al. Identification of acquired antimicrobial resistance genes. J Antimicrob Chemother. 2012;67(11):2640-4.  https://doi.org/10.1093/jac/dks261  PMID: 22782487 
  6. Kleborate v0·3·0. San Francisco: GitHub. [Accessed: 16 Dec 2019]. Available from: https://github.com/katholt/Kleborate
  7. European Nucleotide Archive. Study: PRJEB35890. European study on Klebsiella pneumoniae carrying both NDM-1 and OXA-48. Hinxton: The European Bioinformatics Institute (EMBL-EBI); 2020. Available from: www.ebi.ac.uk/ena/data/view/PRJEB35890
  8. European Centre for Disease Prevention and Control (ECDC). Rapid risk assessment: Regional outbreak of New Delhi metallo-betalactamase-producing carbapenem-resistant Enterobacteriaceae, Italy, 2018-2019. Stockholm ECDC; 2019. Available from: https://ecdc.europa.eu/sites/portal/files/documents/04-Jun-2019-RRA-Carbapenems%2C%20Enterobacteriaceae-Italy.pdf
  9. European Centre for Disease Prevention and Control (ECDC). Rapid risk assessment: Outbreak of carbapenemase-producing Enterobacterales in Lithuania, 2019. Stockholm: ECDC; 2019. Available from: https://www.ecdc.europa.eu/sites/default/files/documents/AMR-rapid-risk-assessment-outbreak%20-of-carbapenemase-producing-Enterobacterales-Lithuania.pdf
  10. Shamina OV, Kryzhanovskaya OA, Lazareva AV, Alyabieva NM, Polikarpova SV, Karaseva OV, et al. Emergence of the ST307 clone carrying a novel insertion element MITEKpn1 in the mgrB gene among carbapenem-resistant Klebsiella pneumoniae from Moscow, Russia. Int J Antimicrob Agents. 2020;55(2):105850.  https://doi.org/10.1016/j.ijantimicag.2019.11.007  PMID: 31770629 
  11. Barguigua A, El Otmani F, Lakbakbi El Yaagoubi F, Talmi M, Zerouali K, Timinouni M. First report of a Klebsiella pneumoniae strain coproducing NDM-1, VIM-1 and OXA-48 carbapenemases isolated in Morocco. APMIS. 2013;121(7):675-7.  https://doi.org/10.1111/apm.12034  PMID: 23278254 
  12. Ben Nasr A, Decré D, Compain F, Genel N, Barguellil F, Arlet G. Emergence of NDM-1 in association with OXA-48 in Klebsiella pneumoniae from Tunisia. Antimicrob Agents Chemother. 2013;57(8):4089-90.  https://doi.org/10.1128/AAC.00536-13  PMID: 23752514 
  13. Solgi H, Giske CG, Badmasti F, Aghamohammad S, Havaei SA, Sabeti S, et al. Emergence of carbapenem resistant Escherichia coli isolates producing blaNDM and blaOXA-48-like carried on IncA/C and IncL/M plasmids at two Iranian university hospitals. Infect Genet Evol. 2017;55:318-23.  https://doi.org/10.1016/j.meegid.2017.10.003  PMID: 28987805 
  14. Khalifa HO, Soliman AM, Ahmed AM, Shimamoto T, Hara T, Ikeda M, et al. High carbapenem resistance in clinical gram-negative pathogens isolated in Egypt. Microb Drug Resist. 2017;23(7):838-44.  https://doi.org/10.1089/mdr.2015.0339  PMID: 28191865 
  15. Cizmeci Z, Aktas E, Otlu B, Acikgoz O, Ordekci S. Molecular characterization of carbapenem- resistant Enterobacteriaceae yields increasing rates of NDM-1 carbapenemases and colistin resistance in an OXA-48- endemic area. J Chemother. 2017;29(6):344-50.  https://doi.org/10.1080/1120009X.2017.1323149  PMID: 28486840 
  16. Revez J, Espinosa L, Albiger B, Leitmeyer KC, Struelens MJECDC National Microbiology Focal Points and Experts Group. Survey on the use of whole-genome sequencing for infectious diseases surveillance: rapid expansion of European national capacities, 2015-2016. Front Public Health. 2017;5:347.  https://doi.org/10.3389/fpubh.2017.00347  PMID: 29326921 
  17. European Centre for Disease Prevention and Control (ECDC). Monitoring the use of whole-genome sequencing in infectious disease surveillance in Europe 2015–2017. Stockholm: ECDC; 2018. Available from: https://www.ecdc.europa.eu/sites/portal/files/documents/whole-genome-sequencing-infectious-disease-surveillance-Europe-2015-2017.pdf
/content/10.2807/1560-7917.ES.2020.25.20.2000627
Loading

Data & Media loading...

Comment has been disabled for this content
Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error