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Abstract

We whole-genome sequenced 55 SARS-CoV-2 isolates from Germany to investigate SARS-CoV-2 outbreaks in 2020 in the Heinsberg district and Düsseldorf. While the genetic structure of the Heinsberg outbreak indicates a clonal origin, reflecting superspreading dynamics from mid-February during the carnival season, distinct viral strains were circulating in Düsseldorf in March, reflecting the city’s international links. Limited detection of Heinsberg strains in the Düsseldorf area despite geographical proximity may reflect efficient containment and contact-tracing efforts.

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/content/10.2807/1560-7917.ES.2020.25.22.2000746
2020-06-04
2025-05-01
/content/10.2807/1560-7917.ES.2020.25.22.2000746
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Genetic structure of SARS-CoV-2 reflects clonal superspreading and multiple independent introduction events, North-Rhine Westphalia, Germany, February and March 2020
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Andreas+Walker&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Walker Andreas</a>, <a href="/search?value1=Torsten+Houwaart&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Houwaart Torsten</a>, <a href="/search?value1=Tobias+Wienemann&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Wienemann Tobias</a>, <a href="/search?value1=Malte+Kohns+Vasconcelos&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Vasconcelos Malte Kohns</a>, <a href="/search?value1=Daniel+Strelow&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Strelow Daniel</a>, <a href="/search?value1=Tina+Senff&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Senff Tina</a>, <a href="/search?value1=Lisanna+H%C3%BClse&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hülse Lisanna</a>, <a href="/search?value1=Ortwin+Adams&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Adams Ortwin</a>, <a href="/search?value1=Marcel+Andree&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Andree Marcel</a>, <a href="/search?value1=Sandra+Hauka&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hauka Sandra</a>, <a href="/search?value1=Torsten+Feldt&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Feldt Torsten</a>, <a href="/search?value1=Bj%C3%B6rn-Erik+Jensen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jensen Björn-Erik</a>, <a href="/search?value1=Verena+Keitel&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Keitel Verena</a>, <a href="/search?value1=Detlef+Kindgen-Milles&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kindgen-Milles Detlef</a>, <a href="/search?value1=J%C3%B6rg+Timm&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Timm Jörg</a>, <a href="/search?value1=Klaus+Pfeffer&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pfeffer Klaus</a>, <a href="/search?value1=Alexander+T+Dilthey&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Dilthey Alexander T</a></span>. Genetic structure of SARS-CoV-2 reflects clonal superspreading and multiple independent introduction events, North-Rhine Westphalia, Germany, February and March 2020. <a href="/content/ecdc">Euro Surveill.</a> 2020;25(22):pii=2000746. <a href="https://doi.org/10.2807/1560-7917.ES.2020.25.22.2000746" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2020.25.22.2000746</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 25 Apr 2020;&nbsp;&nbsp; <span class="generated">Accepted</span>: 04 Jun 2020 </span> </p>
/content/10.2807/1560-7917.ES.2020.25.22.2000746
/content/10.2807/1560-7917.ES.2020.25.22.2000746
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