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Abstract

Most cases of coronavirus disease 2019 are mild or asymptomatic. Therefore, many cases remain unrecorded. We determined seroprevalence of IgG antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 3,186 regular blood donors in three German federal states between 9 March and 3 June 2020. The IgG seroprevalence was 0.91% (95% confidence interval (CI): 0.58–1.24) overall, ranging from 0.66% (95% CI: 0.13–1.19) in Hesse to 1.22% (95% CI: 0.33–2.10) in Lower-Saxony.

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/content/10.2807/1560-7917.ES.2020.25.28.2001285
2020-07-16
2020-10-28
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2020.25.28.2001285
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References

  1. Sharma R, Agarwal M, Gupta M, Somendra S, Saxena SK. Clinical characteristics and differential clinical diagnosis of novel coronavirus disease 2019 (COVID-19). In: Saxena S. (editor). Coronavirus disease 2019 (COVID-19). Medical virology: from pathogenesis to disease control. Springer, Singapore:2020; p 55–70. https://doi.org/ https://doi.org/10.1007/978-981-15-4814-7_6 
  2. Palacios Cruz M, Santos E, Velázquez Cervantes MA, León Juárez M. COVID-19, a worldwide public health emergency. Rev Clin Esp. 2020;S0014-2565(20)30092-8. (Forthcoming).  https://doi.org/10.1016/j.rceng.2020.03.001  PMID: 32204922 
  3. Day M. Covid-19: four fifths of cases are asymptomatic, China figures indicate. BMJ. 2020;369:m1375.  https://doi.org/10.1136/bmj.m1375  PMID: 32241884 
  4. Day M. Covid-19: identifying and isolating asymptomatic people helped eliminate virus in Italian village. BMJ. 2020;368:m1165.  https://doi.org/10.1136/bmj.m1165  PMID: 32205334 
  5. Zhang W, Du R-H, Li B, Zheng X-S, Yang X-L, Hu B, et al. Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes. Emerg Microbes Infect. 2020;9(1):386-9.  https://doi.org/10.1080/22221751.2020.1729071  PMID: 32065057 
  6. United States Food and Drug Administration (FDA). EUA authorized serology test performance. Silver Spring: FDA; 29 Jun 2020. Available from: https://www.fda.gov/medical-devices/emergency-situations-medical-devices/eua-authorized-serology-test-performance
  7. Lassaunière R, Frische A, Harboe ZB, Nielsen ACY, Fomsgaard A, Krogfelt KA, et al. Evaluation of nine commercial SARS-CoV-2 immunoassays. medRxiv. 2020.04.09.20056325 (preprint). https://doi.org/ https://doi.org/10.1101/2020.04.09.20056325 
  8. Montesinos I, Gruson D, Kabamba B, Dahma H, Van den Wijngaert S, Reza S, et al. Evaluation of two automated and three rapid lateral flow immunoassays for the detection of anti-SARS-CoV-2 antibodies. J Clin Virol. 2020;128:104413.  https://doi.org/10.1016/j.jcv.2020.104413  PMID: 32403010 
  9. Meyer B, Torriani G, Yerly S, Mazza L, Calame A, Arm-Vernez I, et al. Validation of a commercially available SARS-CoV-2 serological immunoassay. Clin Microbiol Infect. 2020;S1198-743X(20)30368-2.
  10. Streeck H, Schulte B, Kuemmerer B, Richter E, Hoeller T, Fuhrmann C, et al. Infection fatality rate of SARS-CoV-2 infection in a German community with a super-spreading event. medRxiv. 2020.05.04.20090076 (preprint). https://doi.org/ https://doi.org/10.1101/2020.05.04.20090076 
  11. Wu F, Wang A, Liu M, Wang Q, Chen J, Xia S, et al. Neutralizing antibody responses to SARS-CoV-2 in a COVID-19 recovered patient cohort and their implications. medRxiv 2020.03.30.20047365 (preprint).
  12. Universitätsklinikum Eppendorf (UKE). Nur geringe Anzahl an Blutspendenden weist Antikörper gegen neuartiges Corona-Virus auf. [Only a small number of blood donations show antibodies against new coronavirus]. Hamburg: UKE; 9 Jun 2020. German. Available from: https://www.uke.de/allgemein/presse/pressemitteilungen/detailseite_95424.html
  13. Debatin K-M, Henneke P, Hoffmann GF, Kräusslich H-G, Renk H. Prevalence of COVID-19 in children in Baden-Württemberg. Preliminary study report. Heidelberg: Universitätsklinikum Heidelberg. [Accessed date: 13 Jul 2020]. German. Available from: https://www.klinikum.uni-heidelberg.de/fileadmin/pressestelle/Kinderstudie/Prevalence_of_COVID-19_in_BaWu__.pdf
  14. Robert-Koch-Institut (RKI). COVID-19: Fallzahlen in Deutschland und weltweit. [COVID-19: Case numbers in Germany and worldwide]. Berlin: RKI. [Accessed: 17 Jun 2020]. German. Available from: https://www.rki.de/DE/Content/InfAZ/N/Neuartiges_Coronavirus/Fallzahlen.html
  15. Percivalle E, Cambiè G, Cassaniti I, Nepita EV, Maserati R, Ferrari A, et al. Prevalence of SARS-CoV-2 specific neutralising antibodies in blood donors from the Lodi Red Zone in Lombardy, Italy, as at 06 April 2020. Euro Surveill. 2020;25(24):2001031.  https://doi.org/10.2807/1560-7917.ES.2020.25.24.2001031  PMID: 32583766 
  16. Pollán M, Pérez-Gómez B, Pastor-Barriuso R, Oteo J, Hernán MA, Pérez-Olmeda M, et al. Prevalence of SARS-CoV-2 in Spain (ENE-COVID): a nationwide, population-based seroepidemiological study. Lancet. 2020;S0140-6736(20)31483-5. (Forthcoming). PMID: 32645347 
  17. Flaxman S, Mishra S, Gandy A, Unwin HJT, Mellan TA, Coupland H, et al. Estimating the effects of non-pharmaceutical interventions on COVID-19 in Europe. Nature. 2020.  https://doi.org/10.1038/s41586-020-2405-7  PMID: 32512579 
  18. Altmann DM, Douek DC, Boyton RJ. What policy makers need to know about COVID-19 protective immunity. Lancet. 2020;395(10236):1527-9.  https://doi.org/10.1016/S0140-6736(20)30985-5  PMID: 32353328 
  19. Mo H, Zeng G, Ren X, Li H, Ke C, Tan Y, et al. Longitudinal profile of antibodies against SARS-coronavirus in SARS patients and their clinical significance. Respirology. 2006;11(1):49-53.  https://doi.org/10.1111/j.1440-1843.2006.00783.x  PMID: 16423201 
  20. Liu X, Wang J, Xu X, Liao G, Chen Y, Hu C-H. Patterns of IgG and IgM antibody response in COVID-19 patients. Emerg Microbes Infect. 2020;9(1):1269-74.  https://doi.org/10.1080/22221751.2020.1773324  PMID: 32515684 
  21. Cervia C, Nilsson J, Zurbuchen Y, Valaperti A, Schreiner J, Wolfensberger A, et al. Systemic and mucosal antibody secretion specific to SARS-CoV-2 during mild versus severe COVID-19. bioRxiv 2020.05.21.108308 (preprint). https://doi.org/ https://doi.org/10.1101/2020.05.21.108308 
  22. Long Q-X, Liu B-Z, Deng H-J, Wu GC, Deng K, Chen YK, et al. Antibody responses to SARS-CoV-2 in patients with COVID-19. Nat Med. 2020;26(6):845-8.  https://doi.org/10.1038/s41591-020-0897-1  PMID: 32350462 
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