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Abstract

From September to October 2019, seven patients colonised or infected with a ceftazidime-avibactam (CZA)-resistant carbapenemase (KPC)-2-producing were detected in two intensive care units of a Greek general hospital. The outbreak strain was sequence type (ST)147 and co-produced KPC-2 and the novel plasmid-borne Vietnamese extended-spectrum β-lactamase (VEB)-25 harbouring a K234R substitution associated with CZA resistance. Epidemiological investigations revealed that the resistance was probably acquired by horizontal transmission independently from previous CZA exposure.

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/content/10.2807/1560-7917.ES.2020.25.3.2000028
2020-01-23
2024-04-20
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2020.25.3.2000028
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Outbreak of KPC-2-producing Klebsiella pneumoniae endowed with ceftazidime-avibactam resistance mediated through a VEB-1-mutant (VEB-25), Greece, September to October 2019
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Irene+Galani&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Galani Irene</a>, <a href="/search?value1=Ilias+Karaiskos&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Karaiskos Ilias</a>, <a href="/search?value1=Maria+Souli&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Souli Maria</a>, <a href="/search?value1=Vassiliki+Papoutsaki&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Papoutsaki Vassiliki</a>, <a href="/search?value1=Lamprini+Galani&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Galani Lamprini</a>, <a href="/search?value1=Aikaterini+Gkoufa&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gkoufa Aikaterini</a>, <a href="/search?value1=Anastasia+Antoniadou&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Antoniadou Anastasia</a>, <a href="/search?value1=Helen+Giamarellou&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Giamarellou Helen</a></span>. Outbreak of KPC-2-producing Klebsiella pneumoniae endowed with ceftazidime-avibactam resistance mediated through a VEB-1-mutant (VEB-25), Greece, September to October 2019. <a href="/content/ecdc">Euro Surveill.</a> 2020;25(3):pii=2000028. <a href="https://doi.org/10.2807/1560-7917.ES.2020.25.3.2000028" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2020.25.3.2000028</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 11 Jan 2020;&nbsp;&nbsp; <span class="generated">Accepted</span>: 23 Jan 2020 </span> </p>
/content/10.2807/1560-7917.ES.2020.25.3.2000028
/content/10.2807/1560-7917.ES.2020.25.3.2000028
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