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Abstract

Severe acute respiratory syndrome coronavirus 2 viral load in the upper respiratory tract peaks around symptom onset and infectious virus persists for 10 days in mild-to-moderate coronavirus disease (n = 324 samples analysed). RT-PCR cycle threshold (Ct) values correlate strongly with cultivable virus. Probability of culturing virus declines to 8% in samples with Ct > 35 and to 6% 10 days after onset; it is similar in asymptomatic and symptomatic persons. Asymptomatic persons represent a source of transmissible virus.

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/content/10.2807/1560-7917.ES.2020.25.32.2001483
2020-08-13
2024-04-16
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2020.25.32.2001483
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Duration of infectiousness and correlation with RT-PCR cycle threshold values in cases of COVID-19, England, January to May 2020
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Anika+Singanayagam&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Singanayagam Anika</a>, <a href="/search?value1=Monika+Patel&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Patel Monika</a>, <a href="/search?value1=Andre+Charlett&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Charlett Andre</a>, <a href="/search?value1=Jamie+Lopez+Bernal&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lopez Bernal Jamie</a>, <a href="/search?value1=Vanessa+Saliba&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Saliba Vanessa</a>, <a href="/search?value1=Joanna+Ellis&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ellis Joanna</a>, <a href="/search?value1=Shamez+Ladhani&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ladhani Shamez</a>, <a href="/search?value1=Maria+Zambon&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Zambon Maria</a>, <a href="/search?value1=Robin+Gopal&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gopal Robin</a></span>. Duration of infectiousness and correlation with RT-PCR cycle threshold values in cases of COVID-19, England, January to May 2020. <a href="/content/ecdc">Euro Surveill.</a> 2020;25(32):pii=2001483. <a href="https://doi.org/10.2807/1560-7917.ES.2020.25.32.2001483" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2020.25.32.2001483</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 03 Aug 2020;&nbsp;&nbsp; <span class="generated">Accepted</span>: 12 Aug 2020 </span> </p>
/content/10.2807/1560-7917.ES.2020.25.32.2001483
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