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Abstract

Introduction

Increasing rates of antimicrobial resistance in cause problems for treating gonorrhoea.

Aim

This observational study aimed to describe isolates from all patients found infected with , in Barcelona, Spain, between 2013 and 2017, and with available antimicrobial susceptibility data.

Methods

Minimum inhibitory concentrations (MICs) of penicillin (PEN), cefixime (CFM), ceftriaxone (CRO), azithromycin (AZM), ciprofloxacin (CIP), spectinomycin (SPT), fosfomycin (FOF) and gentamicin (GEN) were determined by E-test. Susceptibility was assessed using clinical breakpoints from the European Committee on Antimicrobial Susceptibility Testing. Time trends for PEN, CFM, AZM and CIP were investigated using logistic regression.

Results

Of 1,979 patients with infection (2,036 isolates), 1,888 (95.4%) were men. Patient median age was 32 years. The proportions of isolates resistant to extended-spectrum cephalosporins were low, with 0.3% (5/1,982) resistant to CRO and 4.9% (98/1,985) to CFM. AZM resistance prevalence was 2.7% (52/1,981), including 16 isolates detected in 2016 and 2017, with high-level resistance. For CIP, 51.3% (1,018/1,986) of isolates were resistant, and for PEN, 20.1% (399/1,985). All isolates were susceptible to SPT. MIC and MIC values of GEN were 4 and 6 mg/L and of FOF 12 and 24 mg/L, respectively. Between 2013 and 2017, PEN and CFM resistance rates each decreased from 28.1% (92/327) to 12.2% (70/572) and from 8.3% (27/327) to 4.4% (25/572) (p ≤ 0.0073). In contrast, AZM resistance prevalence appeared to increase from 1.5% in 2014 (5/340) to 3.0% (17/572) in 2017. No trend was identified for CIP.

Conclusion

Antimicrobial susceptibility surveillance is important to timely detect new phenotypes and trends.

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2020-10-22
2024-04-19
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Antimicrobial susceptibility of Neisseria gonorrhoeae in Barcelona during a five-year period, 2013 to 2017
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Paula+Salmer%C3%B3n&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Salmerón Paula</a>, <a href="/search?value1=Bel%C3%A9n+Vi%C3%B1ado&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Viñado Belén</a>, <a href="/search?value1=Rachid+El+Ouazzani&option1=author&noRedirect=true" class="nonDisambigAuthorLink">El Ouazzani Rachid</a>, <a href="/search?value1=Marta+Hern%C3%A1ndez&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hernández Marta</a>, <a href="/search?value1=Mar%C3%ADa+Jes%C3%BAs+Barbera&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Barbera María Jesús</a>, <a href="/search?value1=Mireia+Alberny&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Alberny Mireia</a>, <a href="/search?value1=Mireia+Jan%C3%A9&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jané Mireia</a>, <a href="/search?value1=Nieves+Larrosa&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Larrosa Nieves</a>, <a href="/search?value1=Tom%C3%A1s+Pumarola&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pumarola Tomás</a>, <a href="/search?value1=Yannick+Hoyos-Mallecot&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hoyos-Mallecot Yannick</a>, <a href="/search?value1=Judit+Serra-Pladevall&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Serra-Pladevall Judit</a></span>. Antimicrobial susceptibility of Neisseria gonorrhoeae in Barcelona during a five-year period, 2013 to 2017. <a href="/content/ecdc">Euro Surveill.</a> 2020;25(42):pii=1900576. <a href="https://doi.org/10.2807/1560-7917.ES.2020.25.42.1900576" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2020.25.42.1900576</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 16 Sept 2019;&nbsp;&nbsp; <span class="generated">Accepted</span>: 05 Mar 2020 </span> </p>
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