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Abstract

Background

The current carriage study was set up to reinforce surveillance during/after the PCV13-to-PCVC10 switch in Belgium.

Aim

This observational study monitored carriage of (Sp) serotypes, particularly those no longer covered (3, 6A, 19A), as well as (Hi), because PCV10 contains the non-typeable Hi protein D.

Methods

A total of 2,615 nasopharyngeal swabs from children (6–30 months old) attending day care were collected in three periods over 2016–2018. Children’s demographic and clinical characteristics and vaccination status were obtained through a questionnaire. Sp and Hi were identified by culture and PCR. Pneumococcal strains were tested for antimicrobial (non-)susceptibility by disc diffusion and serotyped by Quellung-reaction (Quellung-reaction and PCR for serotypes 3, 6A, 19A).

Results

The carriage prevalence of Sp (> 75%) remained stable over the successive periods but that of Hi increased (87.4%, 664 Hi-carriers/760 in 2016 vs 93.9%, 895/953 in 2017–2018). The proportion of non-PCV13 vaccine serotypes decreased (94.6%, 438 isolates/463 in 2016 vs 89.7%, 599/668 in 2017–2018) while that of PCV13-non-PCV10 vaccine serotypes (3 + 6A + 19A) increased (0.9%, 4 isolates/463 in 2016 vs 7.8%, 52/668 in 2017–2018), with serotype 19A most frequently identified (87.9%, 58/66 isolates). Non-susceptibility of pneumococci against any of the tested antibiotics was stable over the study period (> 44%).

Conclusions

During and after the PCV13-to-PCV10 vaccine switch, the proportion of non-PCV13 serotypes decreased, mainly due to a serotype 19A carriage prevalence increase. These results complement invasive pneumococcal disease surveillance data, providing further basis for pneumococcal vaccination programme policy making.

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2020-02-06
2025-05-21
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How nasopharyngeal pneumococcal carriage evolved during and after a PCV13-to-PCV10 vaccination programme switch in Belgium, 2016 to 2018
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Ine+Wouters&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Wouters Ine</a>, <a href="/search?value1=Stefanie+Desmet&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Desmet Stefanie</a>, <a href="/search?value1=Liesbet+Van+Heirstraeten&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Van Heirstraeten Liesbet</a>, <a href="/search?value1=Sereina+A+Herzog&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Herzog Sereina A</a>, <a href="/search?value1=Philippe+Beutels&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Beutels Philippe</a>, <a href="/search?value1=Jan+Verhaegen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Verhaegen Jan</a>, <a href="/search?value1=Herman+Goossens&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Goossens Herman</a>, <a href="/search?value1=Pierre+Van+Damme&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Van Damme Pierre</a>, <a href="/search?value1=Surbhi+Malhotra-Kumar&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Malhotra-Kumar Surbhi</a>, <a href="/search?value1=Heidi+Theeten&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Theeten Heidi</a>, <a href="/search?value1=NPcarriage+Study+Group&option1=author&noRedirect=true" class="nonDisambigAuthorLink">NPcarriage Study Group</a></span>. How nasopharyngeal pneumococcal carriage evolved during and after a PCV13-to-PCV10 vaccination programme switch in Belgium, 2016 to 2018. <a href="/content/ecdc">Euro Surveill.</a> 2020;25(5):pii=1900303. <a href="https://doi.org/10.2807/1560-7917.ES.2020.25.5.1900303" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2020.25.5.1900303</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 16 May 2019;&nbsp;&nbsp; <span class="generated">Accepted</span>: 10 Dec 2019 </span> </p>
/content/10.2807/1560-7917.ES.2020.25.5.1900303
/content/10.2807/1560-7917.ES.2020.25.5.1900303
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