1887
Perspective Open Access
Like 0

Abstract

Human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP), the use of antiretroviral medication to prevent HIV acquisition, is a highly effective biomedical prevention tool. The World Health Organization (WHO) recommends PrEP for people at substantial risk of HIV infection, as part of combination prevention, and highlights the need for robust evaluation of PrEP programmes. Based on suggested WHO core indicators, we created a concise set of HIV PrEP-related dataset variables, to harmonise the monitoring and evaluation of PrEP programmes across five closely related nations (England, Northern Ireland, Ireland, Scotland and Wales). The dataset is based on the PrEP cascade and is intended to represent the minimum variables needed for reporting and comparison of meaningful data at national and multinational level. The dataset can be modified for settings with different health and surveillance systems. It is intended for public health, academic, clinical and health planning, and public audiences. Here we describe the dataset and illustrate its use with data from the first year of the Scottish National PrEP programme.

Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2021.26.23.2001595
2021-06-10
2024-03-29
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2021.26.23.2001595
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/26/23/eurosurv-26-23-4.html?itemId=/content/10.2807/1560-7917.ES.2021.26.23.2001595&mimeType=html&fmt=ahah

References

  1. McCormack S, Dunn DT, Desai M, Dolling DI, Gafos M, Gilson R, et al. Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): effectiveness results from the pilot phase of a pragmatic open-label randomised trial. Lancet. 2016;387(10013):53-60.  https://doi.org/10.1016/S0140-6736(15)00056-2  PMID: 26364263 
  2. Molina JM, Capitant C, Spire B, Pialoux G, Cotte L, Charreau I, et al. . On-Demand Preexposure Prophylaxis in Men at High Risk for HIV-1 Infection. N Engl J Med. 2015;373(23):2237-46.  https://doi.org/10.1056/NEJMoa1506273  PMID: 26624850 
  3. Baeten JM, Donnell D, Ndase P, Mugo NR, Campbell JD, Wangisi J, et al. Antiretroviral prophylaxis for HIV prevention in heterosexual men and women. N Engl J Med. 2012;367(5):399-410.  https://doi.org/10.1056/NEJMoa1108524  PMID: 22784037 
  4. World Health Organization (WHO). WHO expands recommendation on oral pre-exposure prophylaxis of HIV infection (PrEP). Copenhagen: WHO; 2015. Available from: https://www.who.int/hiv/pub/prep/policy-brief-prep-2015/en
  5. European Centre for Disease Prevention and Control (ECDC). Pre-exposure prophylaxis for HIV prevention in Europe and Central Asia. Monitoring implementation of the Dublin Declaration on partnership to fight HIV/AIDS in Europe and Central Asia - 2018/19 progress report. Stockholm: ECDC; 2019; Available from: https://www.ecdc.europa.eu/en/publications-data/ecdc-evidence-brief-pre-exposure-prophylaxis-hiv-prevention-europe-and-central
  6. Public Health England (PHE). PrEP impact trial. London: PHE. [Accessed: 25 May 2021]. Available from: www.prepimpacttrial.org.uk
  7. Joint United Nations Programme on HIV/AIDS (UNAIDS). HIV Prevention 2020 road map. Geneva: UNAIDS; 2017. Available from: https://www.unaids.org/en/resources/documents/2017/hiv-prevention-2020-road-map
  8. World Health Organization (WHO). WHO implementation tool for pre-exposure prophylaxis (PrEP) of HIV infection. Module 5: monitoring and evaluation. Geneva: WHO; 2018. Available from: https://apps.who.int/iris/bitstream/handle/10665/279834/WHO-CDS-HIV-18.10-eng.pdf?ua=1
  9. Hsu C, Sandford BA. The Delphi technique: making sense of consensus. Practical Assessment, Research, and Evaluation. 2007;12(10).
  10. Tanton C, Geary RS, Clifton S, Field N, Heap KL, Mapp F, et al. Sexual health clinic attendance and non-attendance in Britain: findings from the third National Survey of Sexual Attitudes and Lifestyles (Natsal-3). Sex Transm Infect. 2018;94(4):268-76.  https://doi.org/10.1136/sextrans-2017-053193  PMID: 28974552 
  11. O’Halloran C, Owen G, Croxford S, Sims LB, Gill ON, Nutland W, et al. Current experiences of accessing and using HIV pre-exposure prophylaxis (PrEP) in the United Kingdom: a cross-sectional online survey, May to July 2019. Euro Surveill. 2019;24(48):1900693.  https://doi.org/10.2807/1560-7917.ES.2019.24.48.1900693  PMID: 31796157 
  12. O’Halloran C, Sun S, Nash S, Brown A, Croxford S, Connor N, et al. HIV in the United Kingdom: towards zero HIV transmissions by 2030. 2019 report. London: Public Health England; 2019. Available from: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/858559/HIV_in_the_UK_2019_towards_zero_HIV_transmissions_by_2030.pdf
  13. Brady M, Rodger A, Asboe D, Cambiano V, Clutterbuck D, Desai M, et al. BHIVA/BASHH guidelines on the use of HIV pre-exposure prophylaxis (PrEP). Letchworth: British HIV Association; 2018. https://www.bhiva.org/file/5b729cd592060/2018-PrEP-Guidelines.pdf
/content/10.2807/1560-7917.ES.2021.26.23.2001595
Loading

Data & Media loading...

Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error