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Abstract

When facing an emerging virus outbreak such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a quick reaction time is key to control the spread. It takes time to develop antivirals and vaccines, and implement vaccination campaigns. Therefore, preventive measures such as rapid isolation of cases and identification and early quarantine of cases’ close contacts—as well as masks, physical distancing, hand hygiene, surface disinfection and air control—are crucial to reduce the risk of transmission. In this context, disinfectants and antiseptics with proven efficacy against the outbreak virus should be used. However, biocidal formulations are quite complex and may include auxiliary substances such as surfactants or emollients in addition to active substances. In order to evaluate disinfectants’ efficacy objectively, meaningful efficacy data are needed. Therefore, the European Committee for Standardisation technical committee 216 ‘Chemical disinfectants and antiseptics’ Working Group 1 (medical area) has developed standards for efficacy testing. The European tiered approach grades the virucidal efficacy in three levels, with corresponding marker test viruses. In the case of SARS-CoV-2, disinfectants with proven activity against vaccinia virus, the marker virus for the European claim ‘active against enveloped viruses’, should be used to ensure effective hygiene procedures to control the pandemic.

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/content/10.2807/1560-7917.ES.2021.26.3.2000708
2021-01-21
2021-05-13
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2021.26.3.2000708
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References

  1. Lurie N, Saville M, Hatchett R, Halton J. Developing Covid-19 Vaccines at Pandemic Speed. N Engl J Med. 2020;382(21):1969-73.  https://doi.org/10.1056/NEJMp2005630  PMID: 32227757 
  2. Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020;382(8):727-33.  https://doi.org/10.1056/NEJMoa2001017  PMID: 31978945 
  3. Chua KB, Bellini WJ, Rota PA, Harcourt BH, Tamin A, Lam SK et al. Nipah virus: a recently emergent deadly paramyxovirus. Science. 2000;288:1432-35.4.
  4. Peiris JS, Yuen KY, Osterhaus AD, Stohr K. The severe acute respiratory syndrome. N Engl J Med. 2003;349:2431-41.5.
  5. Zaki AM, van Boheemen S, Bestebroer TM, Osterhaus AD, Fouchier RA. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med. 2012;367:1814-20.6.
  6. Piot P, Spencer J. From 1976 to 2018: reflections on early investigations into the Ebola virus. Trans R Soc Trop Med Hyg. 2018;112:527-28.7.
  7. Suk JE, Van Cangh T, Beauté J, Bartels C, Tsolova S, Pharris A, et al. The interconnected and cross-border nature of risks posed by infectious diseases. Glob Health Action. 2014;7(1):25287.  https://doi.org/10.3402/gha.v7.25287  PMID: 25308818 
  8. World Health Organization (WHO). WHO COVID-19. Experimental Treatments. Classification of treatment types. Geneva: WHO; 2020. Available from: https://www.who.int/docs/de-fault-source/coronaviruse/covid-classi-fication-of-treatment-types-rev.pdf
  9. World Health Organization (WHO). DRAFT landscape of COVID-19 candidate vaccines 2020. Geneva: WHO. [Accessed 20 Jan 2021]. Available from: https://www.who.int/publications/m/item/draft-landscape-of-covid-19-candidate-vaccines
  10. European Centre for Disease Prevention and Control (ECDC). Risk related to spread of new SARS-CoV-2 variants of concern in the EU/EEA –29 December2020. Stockholm: ECDC; 2020. Available from: https://www.ecdc.europa.eu/en/publications-data/covid-19-risk-assessment-spread-new-sars-cov-2-variants-eueea
  11. Chu DK, Akl EA, Duda S, Solo K, Yaacoub S, Schünemann HJ, et al. Physical distancing, face masks, and eye protection to prevent person-to-person transmission of SARS-CoV-2 and COVID-19: a systematic review and meta-analysis. Lancet. 2020;395(10242):1973-87.  https://doi.org/10.1016/S0140-6736(20)31142-9  PMID: 32497510 
  12. Liu Y, Li T, Deng Y, Liu S, Zhang D, Li H, et al. Stability of SARS-CoV-2 on environmental surfaces and in human excreta. J Hosp Infect. 2021;107:105-7.  https://doi.org/10.1016/j.jhin.2020.10.021  PMID: 33137445 
  13. Eggers M, Eickmann M, Kowalski K, Zorn J, Reimer K. Povidone-iodine hand wash and handrub products demonstrated excellent in vitro virucidal efficacy against Ebola virus and modified vaccinia virus Ankara, the new European test virus for enveloped viruses. BMC Infect Dis. 2015;15(1):375.  https://doi.org/10.1186/s12879-015-1111-9  PMID: 26381737 
  14. Eggers M, Eickmann M, Zorn J. Rapid and Effective Virucidal Activity of Povidone-Iodine Products Against Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and Modified Vaccinia Virus Ankara (MVA). Infect Dis Ther. 2015;4(4):491-501.  https://doi.org/10.1007/s40121-015-0091-9  PMID: 26416214 
  15. Siddharta A, Pfaender S, Vielle NJ, Dijkman R, Friesland M, Becker B, et al. Virucidal Activity of World Health Organization-Recommended Formulations Against Enveloped Viruses, Including Zika, Ebola, and Emerging Coronaviruses. J Infect Dis. 2017;215(6):902-6.  https://doi.org/10.1093/infdis/jix046  PMID: 28453839 
  16. Anderson DE, Sivalingam V, Kang AEZ, Ananthanarayanan A, Arumugam H, Jenkins TM, et al. Povidone-Iodine Demonstrates Rapid In Vitro Virucidal Activity Against SARS-CoV-2, The Virus Causing COVID-19 Disease. Infect Dis Ther. 2020;9(3):669-75.  https://doi.org/10.1007/s40121-020-00316-3  PMID: 32643111 
  17. Kratzel A, Todt D, V’kovski P, Steiner S, Gultom M, Thao TTN, et al. Inactivation of Severe Acute Respiratory Syndrome Coronavirus 2 by WHO-Recommended Hand Rub Formulations and Alcohols. Emerg Infect Dis. 2020;26(7):1592-5.  https://doi.org/10.3201/eid2607.200915  PMID: 32284092 
  18. EN 14476:2013+A1:2015+prA2:2019. Chemical disinfectants and antiseptics. Quantitative suspension test for the evaluation of virucidal activity in the medical area. Test method and requirements (Phase 2/Step 1).
  19. EN 14885:2018. Chemical disinfectants and antiseptics - Application of European Standards for chemical disinfectants and antiseptics.
  20. Kramer A, Schwebke I, Kampf G. How long do nosocomial pathogens persist on inanimate surfaces? A systematic review. BMC Infect Dis. 2006;6(1):130.  https://doi.org/10.1186/1471-2334-6-130  PMID: 16914034 
  21. Otter JA, Yezli S, French GL. The role played by contaminated surfaces in the transmission of nosocomial pathogens. Infect Control Hosp Epidemiol. 2011;32(7):687-99.  https://doi.org/10.1086/660363  PMID: 21666400 
  22. van Klingeren B. Disinfectant testing on surfaces. J Hosp Infect. 1995;30(Suppl):397-408.  https://doi.org/10.1016/0195-6701(95)90044-6  PMID: 7560978 
  23. van Klingerem B, Koller W, Bloomfield SF, Böhm R, Cremieux A, Holah J, et al. Assessment of the efficacy of disinfectants on surfaces. Int Biodeterior Biodegradation. 1998;41(3-4):289-96.  https://doi.org/10.1016/S0964-8305(98)00020-1 
  24. Rabenau HF, Steinmann J, Rapp I, Schwebke I, Eggers M. Evaluation of a virucidal quantitative carrier test for surface disinfectants. PLoS One. 2014;9(1):e86128.  https://doi.org/10.1371/journal.pone.0086128  PMID: 24475079 
  25. EN 16777:2018. Chemical disinfectants and antiseptics - Quantitative non-porous surface test without mechanical action for the evaluation of virucidal activity of chemical disinfectants used in the medical area - Test method and requirements (phase 2/step 2); German version.
  26. EN 1500:2013 Chemical disinfectants and antiseptics. Hygienic handrub. Test method and requirements (Phase 2/Step 2).
  27. Schürmann W, Eggers HJ. Antiviral activity of an alcoholic hand disinfectant. Comparison of the in vitro suspension test with in vivo experiments on hands, and on individual fingertips. Antiviral Res. 1983;3(1):25-41.  https://doi.org/10.1016/0166-3542(83)90012-8  PMID: 6870229 
  28. prEN17430:2019. Chemical disinfectants and antiseptics - Hygienic handrub virucidal - Test method and requirements (phase 2/step 2).
  29. Eggers M, Benzinger C, Suchomel M, Hjorth E. Virucidal activity of three ethanol-based hand rubs against murine norovirus in a hand hygiene clinical simulation study. Future Microbiol. 2020;15(14):1335-41.; Epub ahead of print.  https://doi.org/10.2217/fmb-2020-0168  PMID: 32960094 
  30. EN 17111:2018. Chemical disinfectants and antiseptics - Quantitative carrier test for the evaluation of virucidal activity for instruments used in the medical area - Test method and requirements (phase 2, step 2); German version
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