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In October and November 2020, we conducted a survey of 2,678 healthcare workers (HCWs) involved in general population immunisation in France, French-speaking Belgium and Quebec, Canada to assess acceptance of future COVID-19 vaccines (i.e. willingness to receive or recommend these) and its determinants. Of the HCWs, 48.6% (n = 1,302) showed high acceptance, 23.0% (n = 616) moderate acceptance and 28.4% (n = 760) hesitancy/reluctance. Hesitancy was mostly driven by vaccine safety concerns. These must be addressed before/during upcoming vaccination campaigns.


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  1. European Centre for Disease Prevention and Control (ECDC). First COVID-19 vaccine authorised for use in the European Union. Stockholm: ECDC; 21 Dec 2020. Available from: https://www.ecdc.europa.eu/en/news-events/first-covid-19-vaccine-authorised-use-european-union
  2. European Medicines Agency (EMA). EMA recommends COVID-19 Vaccine Moderna for authorisation in the EU. Amsterdam: EMA; 06 Jan 2021. Available from: https://www.ema.europa.eu/en/news/ema-recommends-covid-19-vaccine-moderna-authorisation-eu
  3. World Health Organizatin (WHO). WHO SAGE roadmap for prioritizing uses of Covid-19 vaccines in the context of limited supply. Geneva: WHO; 2020. Available from: https://www.who.int/docs/default-source/immunization/sage/covid/sage-prioritization-roadmap-covid19-vaccines.pdf?Status=Temp&sfvrsn=bf227443_2
  4. Haute Autorité de Santé (HAS). Stratégie de vaccination contre la Covid-19. [Vaccination strategy against Covid-19]. Saint-Denis la Plaine: HAS; 23 Dec 2020. Available from: https://www.has-sante.fr/upload/docs/application/pdf/2020-12/strategie_vaccination_covid_19_place_vaccin_a_arnm_comirnaty_bnt162b2.pdf
  5. Comité Sur L’immunisation Du Québec. Stratégie de vaccination contre la COVID-19: report de la 2e dose en contexte de pénurie. [Vaccination strategy against Covid-19: postponement of the 2nd dose in a shortage context]. Insitut National de Santé Publique du Québec. 18 Dec 2010. Available from: https://www.inspq.qc.ca/sites/default/files/publications/3098_vaccination_covid19_2e_dose_contexte_penurie.pdf
  6. Conseil Supérieur de la Santé. Le Conseil Supérieur de la Santé et ses partenaires jettent les bases d’une stratégie de vaccination contre la COVID-19 en Belgique. [The High Health Council and its partners lay the foundations for a vaccination strategy against COVID-19 in Belgium]. Brussels: Service Publique Fédéral, santé publique, sécurité de la chaine alimentaire et environement. Available from: https://www.health.belgium.be/fr/le-conseil-superieur-de-la-sante-et-ses-partenaires-jettent-les-bases-dune-strategie-de-vaccination#anchor-37507
  7. Verger P, Fressard L, Collange F, Gautier A, Jestin C, Launay O, et al. Vaccine Hesitancy Among General Practitioners and Its Determinants During Controversies: A National Cross-sectional Survey in France. EBioMedicine. 2015;2(8):891-7.  https://doi.org/10.1016/j.ebiom.2015.06.018  PMID: 26425696 
  8. Turkheimer FE, Hinz R, Cunningham VJ. On the undecidability among kinetic models: from model selection to model averaging. J Cereb Blood Flow Metab. 2003;23(4):490-8.  https://doi.org/10.1097/01.WCB.0000050065.57184.BB  PMID: 12679726 
  9. Wright DB, Hanoteau F, Parkinson C, Tatham A. Perceptions about memory reliability and honesty for children of 3 to 18 years old. Leg Criminol Psychol. 2010;15(2):195-207.  https://doi.org/10.1348/135532508X400347 
  10. Verger P, Dubé E. Restoring confidence in vaccines in the COVID-19 era. Expert Rev Vaccines. 2020;19(11):991-3.  https://doi.org/10.1080/14760584.2020.1825945  PMID: 32940574 
  11. Rousseau C, Moreau N, Dumas M-P, Bost I, Lefebvre S, Atlani-Duault L. Public media communications about H1N1, risk perceptions and immunization behaviours: A Quebec-France comparison. Public Underst Sci. 2015;24(2):225-40.  https://doi.org/10.1177/0963662513495149  PMID: 23942830 
  12. Pfizer and Biontech announce vaccine candidate against COVID-19 achieved success in first interim analysis from phase 3 study. 9 Nov 2020. Available from: https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-announce-vaccine-candidate-against
  13. Bish A, Yardley L, Nicoll A, Michie S. Factors associated with uptake of vaccination against pandemic influenza: a systematic review. Vaccine. 2011;29(38):6472-84.  https://doi.org/10.1016/j.vaccine.2011.06.107  PMID: 21756960 
  14. Lazarus JV, Ratzan SC, Palayew A, Gostin LO, Larson HJ, Rabin K, et al. A global survey of potential acceptance of a COVID-19 vaccine. Nat Med. 2020;1-4. PMID: 33082575 
  15. Peretti-Watel P, Seror V, Cortaredona S, Launay O, Raude J, Verger P, et al. , COCONEL Group. A future vaccination campaign against COVID-19 at risk of vaccine hesitancy and politicisation. Lancet Infect Dis. 2020;20(7):769-70.  https://doi.org/10.1016/S1473-3099(20)30426-6  PMID: 32445713 
  16. Papagiannis D, Malli F, Raptis DG, Papathanasiou IV, Fradelos EC, Daniil Z, et al. Assessment of Knowledge, Attitudes, and Practices towards New Coronavirus (SARS-CoV-2) of Health Care Professionals in Greece before the Outbreak Period. Int J Environ Res Public Health. 2020;17(14):4925.  https://doi.org/10.3390/ijerph17144925  PMID: 32650614 
  17. Gagneux-Brunon A, Detoc M, Bruel S, Tardy B, Rozaire O, Frappe P, et al. Intention to get vaccinations against COVID-19 in French healthcare workers during the first pandemic wave: a cross sectional survey. J Hosp Infect. 2021;108:168-73.  https://doi.org/10.1016/j.jhin.2020.11.020  PMID: 33259883 
  18. Wang K, Wong ELY, Ho KF, Cheung AWL, Chan EYY, Yeoh EK, et al. Intention of nurses to accept coronavirus disease 2019 vaccination and change of intention to accept seasonal influenza vaccination during the coronavirus disease 2019 pandemic: A cross-sectional survey. Vaccine. 2020;38(45):7049-56.  https://doi.org/10.1016/j.vaccine.2020.09.021  PMID: 32980199 
  19. Raude J, Fressard L, Gautier A, Pulcini C, Peretti-Watel P, Verger P. Opening the ‘Vaccine Hesitancy’ black box: how trust in institutions affects French GPs’ vaccination practices. Expert Rev Vaccines. 2016;15(7):937-48.  https://doi.org/10.1080/14760584.2016.1184092  PMID: 27140417 
  20. Kernéis S, Jacquet C, Bannay A, May T, Launay O, Verger P, et al. , EDUVAC Study Group. Vaccine Education of Medical Students: A Nationwide Cross-sectional Survey. Am J Prev Med. 2017;53(3):e97-104.  https://doi.org/10.1016/j.amepre.2017.01.014  PMID: 28237636 
  21. Yaqub O, Castle-Clarke S, Sevdalis N, Chataway J. Attitudes to vaccination: a critical review. Soc Sci Med. 2014;112:1-11.  https://doi.org/10.1016/j.socscimed.2014.04.018  PMID: 24788111 
  22. Karlsson LC, Lewandowsky S, Antfolk J, Salo P, Lindfelt M, Oksanen T, et al. The association between vaccination confidence, vaccination behavior, and willingness to recommend vaccines among Finnish healthcare workers. PLoS One. 2019;14(10):e0224330.  https://doi.org/10.1371/journal.pone.0224330  PMID: 31671115 
  23. Wilson R, Zaytseva A, Bocquier A, Nokri A, Fressard L, Chamboredon P, et al. Vaccine hesitancy and self-vaccination behaviors among nurses in southeastern France. Vaccine. 2020;38(5):1144-51.  https://doi.org/10.1016/j.vaccine.2019.11.018  PMID: 31810781 
  24. Zhu F-C, Guan X-H, Li Y-H, Huang J-Y, Jiang T, Hou L-H, et al. Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomised, double-blind, placebo-controlled, phase 2 trial. Lancet. 2020;396(10249):479-88.  https://doi.org/10.1016/S0140-6736(20)31605-6  PMID: 32702299 
  25. Schaffer DeRoo S, Pudalov NJ, Fu LY. Planning for a COVID-19 Vaccination Program. JAMA. 2020;323(24):2458-9.  https://doi.org/10.1001/jama.2020.8711  PMID: 32421155 

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