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Several studies report high effectiveness of COVID-19 vaccines against SARS-CoV-2 infection and severe disease, however an important knowledge gap is the vaccine effectiveness against transmission (VET). We present estimates of the VET to household and other close contacts in the Netherlands, from February to May 2021, using contact monitoring data. The secondary attack rate among household contacts was lower for fully vaccinated than unvaccinated index cases (11% vs 31%), with an adjusted VET of 71% (95% confidence interval: 63–77).


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  1. de Gier B, de Oliveira Bressane Lima P, van Gaalen RD, de Boer PT, Alblas J, Ruijten M, et al. Occupation- and age-associated risk of SARS-CoV-2 test positivity, the Netherlands, June to October 2020. Euro Surveill. 2020;25(50):2001884.  https://doi.org/10.2807/1560-7917.ES.2020.25.50.2001884  PMID: 33334396 
  2. Center for Infectious Disease Control. Protocol bron- en contactonderzoek COVID-19. [Protocol source and contact tracing]. Bilthoven: Rijksinstituut voor Volksgezondheid en Milieu; 8 July 2021. Dutch. Available from: https://lci.rivm.nl/COVID-19-bco
  3. Snijders BEP, van Lier A, van de Kassteele J, Fanoy EB, Ruijs WLM, Hulshof F, et al. Mumps vaccine effectiveness in primary schools and households, the Netherlands, 2008. Vaccine. 2012;30(19):2999-3002.  https://doi.org/10.1016/j.vaccine.2012.02.035  PMID: 22381073 
  4. Halloran ME, Préziosi M-P, Chu H. Estimating vaccine efficacy from secondary attack rates. J Am Stat Assoc. 2003;98(461):38-46.  https://doi.org/10.1198/016214503388619076 
  5. Harris RJ, Hall JA, Zaidi A, Andrews NJ, Dunbar JK, Dabrera G. Impact of vaccination on household transmission of SARS-COV-2 in England. London: Knowledge Hub; 2021. Available from: https://khub.net/documents/135939561/390853656/Impact+of+vaccination+on+household+transmission+of+SARS-COV-2+in+England.pdf/35bf4bb1-6ade-d3eb-a39e-9c9b25a8122a?t=1619551571214
  6. Shah AS, Gribben C, Bishop J, Hanlon P, Caldwell D, Wood R, et al. Effect of vaccination on transmission of COVID-19: an observational study in healthcare workers and their households. medRxiv. 2021:2021.03.11.21253275.
  7. Martínez-Baz I, Miqueleiz A, Casado I, Navascués A, Trobajo-Sanmartín C, Burgui C, et al. Effectiveness of COVID-19 vaccines in preventing SARS-CoV-2 infection and hospitalisation, Navarre, Spain, January to April 2021. Euro Surveill. 2021;26(21):2100438.  https://doi.org/10.2807/1560-7917.ES.2021.26.21.2100438  PMID: 34047271 
  8. Halloran ME, Haber M, Longini IM Jr, Struchiner CJ. Direct and indirect effects in vaccine efficacy and effectiveness. Am J Epidemiol. 1991;133(4):323-31.  https://doi.org/10.1093/oxfordjournals.aje.a115884  PMID: 1899778 

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