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Abstract

Background

In Denmark, influenza surveillance is ensured by data capturing from existing population-based registers. Since 2017, point-of-care (POC) testing has been implemented outside the regional clinical microbiology departments (CMD).

Aim

We aimed to assess influenza laboratory results in view of the introduction of POC testing.

Methods

We retrospectively observed routine surveillance data on national influenza tests before and after the introduction of POC testing as available in the Danish Microbiological Database. Also, we conducted a questionnaire study among Danish CMD about influenza diagnostics.

Results

Between the seasons 2014/15 and 2018/19, 199,744 influenza tests were performed in Denmark of which 44,161 were positive (22%). After the introduction of POC testing, the overall percentage of positive influenza tests per season did not decrease. The seasonal influenza test incidence was higher in all observed age groups. The number of operating testing platforms placed outside a CMD and with an instrument analytical time ≤ 3 h increased after 2017. Regionally, the number of tests registered as POC in the Danish Microbiological Database and the number of tests performed with an instrument analytical time ≤ 3 h or outside a CMD partially differed. Where comparable (71% of tests), the relative proportion of POC tests out of all tests increased from season 2017/18 to 2018/19. In both seasons, the percentage of positive POC tests resulted slightly lower than for non-POC tests.

Conclusion

POC testing integrated seamlessly into national influenza surveillance. We propose the use of POC results in the routine surveillance of seasonal influenza.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
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/content/10.2807/1560-7917.ES.2021.26.37.2000724
2021-09-16
2024-04-16
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2021.26.37.2000724
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References

  1. Nichols JH. Point of care testing. Clin Lab Med. 2007;27(4):893-908, viii.  https://doi.org/10.1016/j.cll.2007.07.003  PMID: 17950904 
  2. National Center for Biotechnology Information, U.S. National Library of Medicine (NCBI). Point-of-care testing. MeSH database. Bethesda: NCBI. [Accessed: 31 Mar 2020]. Available from: https://www.ncbi.nlm.nih.gov/mesh/?term=point+of+care+testing
  3. Banerjee D, Kanwar N, Hassan F, Essmyer C, Selvarangan R. Comparison of six sample-to-answer influenza A/B and respiratory syncytial virus nucleic acid amplification assays using respiratory specimens from children. J Clin Microbiol. 2018;56(11):e00930-18.  https://doi.org/10.1128/JCM.00930-18  PMID: 30185508 
  4. Egilmezer E, Walker GJ, Bakthavathsalam P, Peterson JR, Gooding JJ, Rawlinson W, et al. Systematic review of the impact of point-of-care testing for influenza on the outcomes of patients with acute respiratory tract infection. Rev Med Virol. 2018;28(5):e1995.  https://doi.org/10.1002/rmv.1995  PMID: 30101552 
  5. Brendish NJ, Schiff HF, Clark TW. Point-of-care testing for respiratory viruses in adults: The current landscape and future potential. J Infect. 2015;71(5):501-10.  https://doi.org/10.1016/j.jinf.2015.07.008  PMID: 26215335 
  6. Lee VJ, Ho ZJM, Goh EH, Campbell H, Cohen C, Cozza V, et al. Advances in measuring influenza burden of disease. Influenza Other Respir Viruses. 2018;12(1):3-9.  https://doi.org/10.1111/irv.12533  PMID: 29460425 
  7. Vestergaard LS, Nielsen J, Krause TG, Espenhain L, Tersago K, Bustos Sierra N, et al. Excess all-cause and influenza-attributable mortality in Europe, December 2016 to February 2017. Euro Surveill. 2017;22(14):30506.  https://doi.org/10.2807/1560-7917.ES.2017.22.14.30506  PMID: 28424146 
  8. Hay AJ, McCauley JW. The WHO global influenza surveillance and response system (GISRS)-A future perspective. Influenza Other Respir Viruses. 2018;12(5):551-7.  https://doi.org/10.1111/irv.12565  PMID: 29722140 
  9. Statens Serum Institut (SSI). Influenzaovervågning generelt. [General influenza surveillance]. Copenhagen: SSI. [Accessed: 31 Mar 2020]. Danish. Available from: https://www.ssi.dk/sygdomme-beredskab-og-forskning/sygdomsovervaagning/i/influenzaovervaagning-generelt
  10. Voldstedlund M, Haarh M, Mølbak K, MiBa Board of Representatives. The Danish Microbiology Database (MiBa) 2010 to 2013. Euro Surveill. 2014;19(1):20667.  https://doi.org/10.2807/1560-7917.ES2014.19.1.20667  PMID: 24434175 
  11. Statens Serum Institut (SSI). Influenza. Copenhagen: SSI. [Accessed: 31 Mar 2020]. Danish. Available from: https://www.ssi.dk/sygdomme-beredskab-og-forskning/sygdomsleksikon/i/influenza
  12. Emborg HD, Krause TG, Nielsen L, Thomsen MK, Christiansen CB, Skov MN, et al. Influenza vaccine effectiveness in adults 65 years and older, Denmark, 2015/16 - a rapid epidemiological and virological assessment. Euro Surveill. 2016;21(14):30189.  https://doi.org/10.2807/1560-7917.ES.2016.21.14.30189  PMID: 27101732 
  13. Dansk Selskab for Klinisk Mikrobiologi (DSKM). Anbefalinger vedrørende implementering og anvendelse af Point-of-Care teknologi til diagnostik af infektionssygdomme. [Recommendations regarding the implementation and application of point-of-care technology for the diagnosis of infectious diseases]. Copenhagen: DSKM; 2017. Danish. Available from: http://dskm.dk/wp-content/uploads/2016/08/POC-Rapport-fra-DSKMs-Udvalg.pdf
  14. Statens Serum Institut (SSI). The 2017/2018 influenza season. EPI-NEWS. 2018;23-24. Copenhagen: SSI; 2018. Available from: https://en.ssi.dk/news/epi-news/2018/no-23-24---2018
  15. Statens Serum Institut (SSI). Influenza season 2018/19. EPI-NEWS. 2019;22-23. Copenhagen: SSI; 2019. Available from: https://en.ssi.dk/news/epi-news/2019/no-22-23---2019
  16. Statistics Denmark. FOLK1A: Population at the first day of the quarter by region, sex, age and marital status. Copenhagen: Statistics Denmark. [Accessed: 31 Mar 2020]. Available from: https://www.statbank.dk/FOLK1A
  17. R Core Team. R: A language and environment for statistical computing. Vienna: R Foundation for Statistical Computing; 2019. Available from: https://www.R-project.org
  18. European Centre for Disease Prevention and Control (ECDC). Seasonal influenza - Annual epidemiological report for 2017-2018. Stockholm: ECDC; 2018. Available from: https://www.ecdc.europa.eu/en/publications-data/seasonal-influenza-annual-epidemiological-report-2017-18-season
  19. European Centre for Disease Prevention and Control (ECDC). Seasonal influenza - Annual Epidemiological Report for 2018-2019. Stockholm: ECDC; 2019. Available from: https://www.ecdc.europa.eu/en/publications-data/seasonal-influenza-annual-epidemiological-report-2018-2019
  20. Larsson A, Greig-Pylypczuk R, Huisman A. The state of point-of-care testing: a European perspective. Ups J Med Sci. 2015;120(1):1-10.  https://doi.org/10.3109/03009734.2015.1006347  PMID: 25622619 
  21. Youngs J, Marshall B, Farragher M, Whitney L, Glass S, Pope C, et al. Implementation of influenza point-of-care testing and patient cohorting during a high-incidence season: a retrospective analysis of impact on infection prevention and control and clinical outcomes. J Hosp Infect. 2019;101(3):276-84.  https://doi.org/10.1016/j.jhin.2018.11.010  PMID: 30471317 
  22. O’Connell S, Conlan C, Reidy M, Stack C, Mulgrew A, Baruah J. The impact of point-of-care testing for influenza A and B on patient flow and management in a medical assessment unit of a general hospital. BMC Res Notes. 2020;13(1):143.  https://doi.org/10.1186/s13104-020-04986-7  PMID: 32156298 
  23. de Lusignan S, Hoang U, Liyanage H, Tripathy M, Yonova I, Byford R, et al. Integrating molecular point-of-care testing for influenza into primary care: a mixed-methods feasibility study. Br J Gen Pract. 2020;70(697):e555-62.  https://doi.org/10.3399/bjgp20X710897  PMID: 32661013 
  24. Meyers L, Ginocchio CC, Faucett AN, Nolte FS, Gesteland PH, Leber A, et al. Automated real-time collection of pathogen-specific diagnostic data: syndromic infectious disease epidemiology. JMIR Public Health Surveill. 2018;4(3):e59.  https://doi.org/10.2196/publichealth.9876  PMID: 29980501 
  25. Gren LH, Porucznik CA, Joy EA, Lyon JL, Staes CJ, Alder SC. Point-of-care testing as an influenza surveillance tool: methodology and lessons learned from implementation. Influenza Res Treat. 2013;2013:242970.  https://doi.org/10.1155/2013/242970  PMID: 23691297 
  26. Dickson EM, Zambon M, Pebody R, de Lusignan S, Elliot AJ, Ellis J, et al. Do point-of-care tests (POCTs) offer a new paradigm for the management of patients with influenza? Euro Surveill. 2020;25(44):1900420.  https://doi.org/10.2807/1560-7917.ES.2020.25.44.1900420  PMID: 33153522 
  27. de Lusignan S, Hoang U, Liyanage H, Yonova I, Ferreira F, Diez-Domingo J, et al. Feasibility of point-of-care testing for influenza within a national primary care sentinel surveillance network in England: protocol for a mixed methods study. JMIR Res Protoc. 2019;8(11):e14186.  https://doi.org/10.2196/14186  PMID: 31710303 
  28. Phin N, Poutanen SM. The cat is out of the bag - point-of-care testing (POCT) is here to stay. Euro Surveill. 2020;25(44):2001854.  https://doi.org/10.2807/1560-7917.ES.2020.25.44.2001854  PMID: 33153521 
Spotlight influenza: Influenza surveillance before and after the introduction of point-of-care testing in Denmark, season 2014/15 to 2018/19
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Guido+Benedetti&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Benedetti Guido</a>, <a href="/search?value1=Tyra+Grove+Krause&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Krause Tyra Grove</a>, <a href="/search?value1=Uffe+Vest+Schneider&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Schneider Uffe Vest</a>, <a href="/search?value1=Jan+Gorm+Lisby&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lisby Jan Gorm</a>, <a href="/search?value1=Marianne+Voldstedlund&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Voldstedlund Marianne</a>, <a href="/search?value1=Didi+Bang&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bang Didi</a>, <a href="/search?value1=Ramona+Trebbien&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Trebbien Ramona</a>, <a href="/search?value1=Hanne-Dorthe+Emborg&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Emborg Hanne-Dorthe</a></span>. Spotlight influenza: Influenza surveillance before and after the introduction of point-of-care testing in Denmark, season 2014/15 to 2018/19. <a href="/content/ecdc">Euro Surveill.</a> 2021;26(37):pii=2000724. <a href="https://doi.org/10.2807/1560-7917.ES.2021.26.37.2000724" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2021.26.37.2000724</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 23 Apr 2020;&nbsp;&nbsp; <span class="generated">Accepted</span>: 09 Feb 2021 </span> </p>
/content/10.2807/1560-7917.ES.2021.26.37.2000724
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