1887
Research Open Access
Like 0

Abstract

Background

In France, human papillomavirus (HPV) vaccination has been recommended in 2016 for men who have sex with men (MSM) up to age 26 years.

Aim

We aimed to estimate HPV vaccine coverage in 18–28 year-old MSM and identify uptake determinants.

Methods

We collected data on socio-demographic characteristics, sexual behaviour, sexually transmitted diseases (STI) screening and vaccination uptake using a voluntary cross-sectional online survey conducted in 2019 targeting MSM. We calculated coverage of at least one dose of HPV vaccine and prevalence ratios (PR) of determinants with 95% confidence intervals (CI) using Poisson regression.

Results

Of 9,469 respondents (age range: 18–28 years), 15% (95% CI: 14–16) reported being vaccinated for HPV. Coverage was significantly higher among MSM < 24 years (PR: 1.25; 95% CI: 1.13–1.39), with education level below university degree (PR: 1.12; 95% CI: 1.08–1.32), living in rural areas (PR: 1.21; 95% CI: 1.08–1.36), attending sex parties (PR: 1.12; 95% CI: 1.03–1.33), using HIV-related biomedical prevention methods (PR: 1.31; 95% CI: 1.12–1.54), with STI diagnosis (PR: 1.22; 95% CI: 1.08–1.38) and with hepatitis A or B vaccination (PR: 4.56; 95% CI: 3.63–5.81 vs PR: 3.35; 95% CI: 2.53–4.44).

Conclusions

The HPV vaccination uptake among MSM in France was not satisfactory. It was higher among MSM benefitting from other vaccinations and biomedical preventive methods against HIV, suggesting a synergistic effect of the national preventive sexual health recommendations for MSM. Further efforts to improve HPV vaccination coverage targeting MSM are warranted.

Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2021.26.50.2001965
2021-12-16
2022-01-22
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2021.26.50.2001965
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/26/50/eurosurv-26-50-7.html?itemId=/content/10.2807/1560-7917.ES.2021.26.50.2001965&mimeType=html&fmt=ahah

References

  1. de Martel C, Plummer M, Vignat J, Franceschi S. Worldwide burden of cancer attributable to HPV by site, country and HPV type. Int J Cancer. 2017;141(4):664-70.  https://doi.org/10.1002/ijc.30716  PMID: 28369882 
  2. Reusser NM, Downing C, Guidry J, Tyring SK. HPV carcinomas in immunocompromised patients. J Clin Med. 2015;4(2):260-81.  https://doi.org/10.3390/jcm4020260  PMID: 26239127 
  3. Machalek DA, Poynten M, Jin F, Fairley CK, Farnsworth A, Garland SM, et al. Anal human papillomavirus infection and associated neoplastic lesions in men who have sex with men: a systematic review and meta-analysis. Lancet Oncol. 2012;13(5):487-500.  https://doi.org/10.1016/S1470-2045(12)70080-3  PMID: 22445259 
  4. Piketty C, Selinger-Leneman H, Bouvier A-M, Belot A, Mary-Krause M, Duvivier C, et al. Incidence of HIV-related anal cancer remains increased despite long-term combined antiretroviral treatment: results from the french hospital database on HIV. J Clin Oncol. 2012;30(35):4360-6.  https://doi.org/10.1200/JCO.2012.44.5486  PMID: 23091098 
  5. Marra E, Lin C, Clifford GM. Type-specific anal human papillomavirus prevalence among men, according to sexual preference and HIV status: a systematic literature review and meta-analysis. J Infect Dis. 2019;219(4):590-8.  https://doi.org/10.1093/infdis/jiy556  PMID: 30239749 
  6. European Centre for Disease Prevention and Control (ECDC). Guidance on HPV vaccination in EU countries: focus on boys, people living with HIV and 9-valent HPV vaccine introduction 2020. Stockholm: ECDC; 2020. Available from: https://www.ecdc.europa.eu/sites/default/files/documents/Guidance-on-HPV-vaccination-in-EU-countries2020-03-30.pdf
  7. Nguyen-Huu NH, Thilly N, Derrough T, Sdona E, Claudot F, Pulcini C, et al. Human papillomavirus vaccination coverage, policies, and practical implementation across Europe. Vaccine. 2020;38(6):1315-31.  https://doi.org/10.1016/j.vaccine.2019.11.081  PMID: 31836255 
  8. Shield KD, Marant Micallef C, de Martel C, Heard I, Megraud F, Plummer M, et al. New cancer cases in France in 2015 attributable to infectious agents: a systematic review and meta-analysis. Eur J Epidemiol. 2018;33(3):263-74.  https://doi.org/10.1007/s10654-017-0334-z  PMID: 29214413 
  9. Avis du comite technique des vaccinations et du conseil superieur d’hygiene publique de France, section des maladies transmissibles, relatif à la vaccination contre les papillomavirus humains 6, 11, 16 et 18 (séances du 9 mars 2007). [Opinion of the technical committee for vaccinations and the French high council for public health (transmissible disease) on vaccination against human papillomaviruses 6, 11, 16 and 18 (meeting on 9 March 2007)]. Paris: Ministère des Solidarités et de la Santé; 2007. French. Available from: https://www.hcsp.fr/docspdf/cshpf/a_mt_090307_papillomavirus.pdf
  10. Haut Conseil de la Santé Publique (HCSP). Avis relatif à la révision de l’âge de vaccination contre les infections à papillomavirus humains des jeunes filles. [Opinion on the revision of the age of vaccination against human papillomavirus infections of young girls]. Paris: HCSP; 2012. French. Available from: https://www.hcsp.fr/explore.cgi/avisrapportsdomaine?clefr=302
  11. Haut Conseil de la Santé Publique (HCSP). Avis relatif à l’utilisation du vaccin contre les infections à papillomavirus humains Gardasil. [Opinion on the use of the vaccine against human papillomavirus infections Gardasil]. Paris: HCSP; 2014. French. Available from: https://www.hcsp.fr/explore.cgi/avisrapportsdomaine?clefr=416
  12. Haut Conseil de la Santé Publique (HCSP). Vaccination des personnes immunodéprimées ou aspléniques. Recommandations actualisées. [Vaccination of immunocompromised or asplenic people. Updated recommendations]. Paris: HCSP; 2014. French. Available from: https://www.hcsp.fr/explore.cgi/avisrapportsdomaine?clefr=504
  13. Haut Conseil de la Santé Publique (HCSP). Recommandations vaccinales contre les infections à papillomavirus humains chez les hommes. [Vaccination recommendations against human papillomavirus infections in men]. Paris: HCSP; 2016. French. Available from: https://www.hcsp.fr/explore.cgi/avisrapportsdomaine?clefr=553
  14. Haut Conseil de la Santé Publique (HCSP). Avis relatif aux recommandations vaccinales contre les infections à papillomavirus humains chez les hommes. [Opinion on vaccine recommendations against human papillomavirus infections in men]. Paris: HCSP; 2016. French. Available from
  15. Conseil nationale du SIDA et des hépatites virales (CNS). Stretégie nationale de santé sexuelle - Agenda 2017 - 2030 -31 Mars 2017. In.; 2017. French. Available from: https://www.hcsp.fr/explore.cgi/avisrapportsdomaine?clefr=553
  16. Collège de la Haute Autorité de santé (HAS). Décision n° 2019.0280/DC/SEESP du 11 décembre 2019 du collège de la Haute Autorité de santé portant adoption de la recommandation vaccinale « Elargissement de la vaccination contre les papillomavirus aux garçons » et de son document de synthèse. [Decision no. 2019.0280/DC/SEESP of 11 December 2019 of the College of the High Authority for Health adopting the vaccine recommendation "Extension of vaccination against papillomavirus to boys" and its summary document]. Saint-Denis: HAS; 2019. French. Available from: https://www.has-sante.fr/jcms/p_3135808/fr/decision-n-2019-0280/dc/seesp-du-11-decembre-2019-du-college-de-la-haute-autorite-de-sante-portant-adoption-de-la-recommandation-vaccinale-elargissement-de-la-vaccination-contre-les-papillomavirus-aux-garcons-et-de-son-document-de-synthese
  17. Santé Publique France. Lieux de vaccination. Saint-Maurice: Santé Publique France; 2019. Available from: https://professionnels.vaccination-info-service.fr/Aspects-pratiques/Acte-vaccinal/Lieux-de-vaccination
  18. https://professionnels.vaccination-info-service.fr/Aspects-pratiques/Acte-vaccinal/Lieux-de-vaccination(HCSP). Recommandations vaccinales contre les infections à papillomavirus humains chez les hommes. [Vaccination recommendations against human papillomavirus infections in men]. Paris: HCSP; 2016. French. Available from: https://www.hcsp.fr/explore.cgi/avisrapportsdomaine?clefr=552
  19. Pioche CNN, Sarr A, Cazein F, Bruyand M, Viriot D, et al. Activité de dépistage et diagnostic du VIH, des hépatites B et C, et des autres IST en CeGIDD, France, 2018. [Screening for and diagnosis of HIV, hepatitis B and C and other STI in CeGIDD, France, 2018]. Bull Epidemiol Hebd (Paris). 2019;31-32:625-33. French.
  20. Duchesne L, Lydié N, Velter A: Increase in the overall level of protected anal sex in men who have sex with men in France: results from the repeated cross-sectional survey Rapport au Sexe, France, 2017-2019. AIDS Care. 2020;32(sup2):162-9.
  21. Petit B, Epaulard O. Men having sex with men and the HPV vaccine in France: A low vaccine coverage that may be due to its infrequent proposal by physicians. Vaccine. 2020;38(9):2160-5.  https://doi.org/10.1016/j.vaccine.2020.01.049  PMID: 32008880 
  22. Collège de la Haute Autorité de santé (HAS). Recommandation vaccinale - Élargissement de la vaccination contre les papillomavirus aux garçons. [Vaccination recommendation - Expansion of vaccination against papillomaviruses to boys]. Saint-Denis: HAS; 2019. French. Available from: https://www.has-sante.fr/jcms/p_3116022/fr/recommandation-sur-l-elargissement-de-la-vaccination-contre-les-papillomavirus-aux-garcons
  23. Human papillomavirus vaccines: WHO position paper, May 2017. Wkly Epidemiol Rec. 2017;92(19):241-68. PMID: 28530369 
  24. Immunize BC. HPV (human papillomavirus). Victoria: Public Health Association of BC. [Accessed: 3 Sep 2020]. Available from: https://immunizebc.ca/hpv
  25. National Immunisation Advisory Committee (NIAC). HPV vaccine for people with HIV and MSM. Dublin: NIAC; 2018. Available from: https://www.hse.ie/eng/health/immunisation/hcpinfo/othervaccines/hpvadults
  26. Edelstein M, Iyanger N, Hennessy N, Mesher D, Checchi M, Soldan K, et al. Implementation and evaluation of the human papillomavirus (HPV) vaccination pilot for men who have sex with men (MSM), England, April 2016 to March 2017. Euro Surveill. 2019;24(8):1800055.  https://doi.org/10.2807/1560-7917.ES.2019.24.8.1800055  PMID: 30808443 
  27. Oliver SE, Hoots BE, Paz-Bailey G, Markowitz LE, Meites E, NHBS Study Group. Increasing human papillomavirus vaccine coverage among men who have sex with men-national HIV behavioral surveillance, United States, 2014. J Acquir Immune Defic Syndr. 2017;75(Suppl 3):S370-4.  https://doi.org/10.1097/QAI.0000000000001413  PMID: 28604441 
  28. Loretan C, Chamberlain AT, Sanchez T, Zlotorzynska M, Jones J. Trends and characteristics associated with human papillomavirus vaccination uptake among men who have sex with men in the United States, 2014-2017. Sex Transm Dis. 2019;46(7):465-73.  https://doi.org/10.1097/OLQ.0000000000001008  PMID: 30994522 
  29. Gerend MA, Madkins K, Phillips G 2nd, Mustanski B. Predictors of human papillomavirus vaccination among young men who have sex with men. Sex Transm Dis. 2016;43(3):185-91.  https://doi.org/10.1097/OLQ.0000000000000408  PMID: 26859806 
  30. Kellogg TA, Hecht J, Bernstein K, McFarland W, Connors A, Perloff L, et al. Comparison of HIV behavioral indicators among men who have sex with men across two survey methodologies, San Francisco, 2004 and 2008. Sex Transm Dis. 2013;40(9):689-94.  https://doi.org/10.1097/01.olq.0000431354.96087.50  PMID: 23945424 
  31. Marcus U, Hickson F, Weatherburn P, Schmidt AJ, EMIS network. Age biases in a large HIV and sexual behaviour-related internet survey among MSM. BMC Public Health. 2013;13(1):826.  https://doi.org/10.1186/1471-2458-13-826  PMID: 24020518 
  32. Méthy N, Velter A, Semaille C, Bajos N. Sexual behaviours of homosexual and bisexual men in France: a generational approach. PLoS One. 2015;10(3):e0123151-0123151.  https://doi.org/10.1371/journal.pone.0123151  PMID: 25816322 
  33. Gorbach PM, Cook R, Gratzer B, Collins T, Parrish A, Moore J, et al. Human papillomavirus vaccination among young men who have sex with men and transgender women in 2 US cities, 2012-2014. Sex Transm Dis. 2017;44(7):436-41.  https://doi.org/10.1097/OLQ.0000000000000626  PMID: 28608795 
  34. Rey D, Fressard L, Cortaredona S, Bocquier A, Gautier A, Peretti-Watel P, et al. Vaccine hesitancy in the French population in 2016, and its association with vaccine uptake and perceived vaccine risk-benefit balance. Euro Surveill. 2018;23(17):17-00816.  https://doi.org/10.2807/1560-7917.ES.2018.23.17.17-00816  PMID: 29717693 
  35. Verrier F, Gautier A, Quelet S, Bonmarin I, et le groupe Baromètre de Santé publique France 2016. Infections à papillomavirus humain: influence des perceptions de la maladie et du vaccin sur le statut vaccinal. [Human papillomavirus infections: influence of perceptions of disease and vaccine on immunisation status]. Bull Epidémiol Hebd. 2019;(22-23):450-6.French.
  36. Kahle EM, Meites E, Sineath RC, Nasrullah M, Bowles KE, DiNenno E, et al. Sexually transmitted disease testing and uptake of human papillomavirus vaccine in a large online survey of US men who have sex with men at risk for HIV infection, 2012. Sex Transm Dis. 2017;44(1):62-6.  https://doi.org/10.1097/OLQ.0000000000000545  PMID: 27898576 
  37. Santé Publique France. Calendrier des vaccinations et recommandations vaccinales 2019. [Vaccination schedule and vaccine recommendations 2019]. Saint-Maurice: Santé Publique France; 2019. French. Available from: https://solidarites-sante.gouv.fr/IMG/pdf/calendrier_vaccinal_mars_2019.pdf
  38. Santé Publique France. Hommes ayant des relations sexuelles avec des hommes. [Men who have sex with men]. Saint-Maurice: Santé Publique France; 2018. French. Available from: https://professionnels.vaccination-info-service.fr/Recommandations-vaccinales-specifiques/Personnes-exposees-a-des-risques-specifiques/Hommes-ayant-des-relations-sexuelles-avec-des-hommes
  39. Potherat GTJ, Epaulard O. Les hommes ayant des rapports sexuels avec des hommes et la médecine générale: mention de l’orientation sexuelle par les patients et impact sur la relation de soin (étude HomoGen). Bull Epidemiol Hebd (Paris). 2019;2019(12):204-10.
  40. Chow EPF, Aung ET, Chen MY, Bradshaw CS, Fairley CK. Human papillomavirus vaccination and sexual practices among men who have sex with men in Melbourne, Australia: a cross-sectional study. Int J STD AIDS. 2020;31(4):312-7.  https://doi.org/10.1177/0956462419897514  PMID: 32063135 
  41. Haute Autorité de Santé. (HAS). La prophylaxie pré-exposition (PrEP) au VIH par ténofovir disoproxil/emtricitabine (TRUVADA et ses génériques). [HIV pre-exposure prophylaxis (PrEP) with tenofovir disoproxil/emtricitabine (TRUVADA and its generics)]. Saint-Denis: HAS; 2019. French. Available from: https://www.has-sante.fr/upload/docs/application/pdf/2019-05/bum_truvada_maj_avril2019.pdf
  42. Meunier É, Siegel K. Sex club/party attendance and STI among men who have sex with men: results from an online survey in New York City. Sex Transm Infect. 2019;95(8):584-7.  https://doi.org/10.1136/sextrans-2018-053816  PMID: 30867250 
/content/10.2807/1560-7917.ES.2021.26.50.2001965
Loading

Data & Media loading...

Supplementary data

Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error