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Risk and protective factors for SARS-CoV-2 reinfections, surveillance data, Italy, August 2021 to March 2022
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Chiara Sacco1
, Daniele Petrone1 , Martina Del Manso1
, Alberto Mateo-Urdiales1
, Massimo Fabiani1
, Marco Bressi1 , Antonino Bella1
, Patrizio Pezzotti1
, Maria Cristina Rota1
, Flavia Riccardo1
, on behalf of the Italian Integrated Surveillance of COVID-19 study group2
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View Affiliations Hide AffiliationsAffiliations: 1 Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy 2 The members of the Italian Integrated Surveillance of COVID-19 study group are acknowledged at the end of the articleChiara Saccochiara.sacco iss.it
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View Citation Hide Citation
Citation style for this article: Sacco Chiara, Petrone Daniele, Del Manso Martina, Mateo-Urdiales Alberto, Fabiani Massimo, Bressi Marco, Bella Antonino, Pezzotti Patrizio, Rota Maria Cristina, Riccardo Flavia, on behalf of the Italian Integrated Surveillance of COVID-19 study group. Risk and protective factors for SARS-CoV-2 reinfections, surveillance data, Italy, August 2021 to March 2022. Euro Surveill. 2022;27(20):pii=2200372. https://doi.org/10.2807/1560-7917.ES.2022.27.20.2200372 Received: 02 May 2022; Accepted: 19 May 2022
Abstract
We explored the risk factors associated with SARS-CoV-2 reinfections in Italy between August 2021 and March 2022. Regardless of the prevalent virus variant, being unvaccinated was the most relevant risk factor for reinfection. The risk of reinfection increased almost 18-fold following emergence of the Omicron variant compared with Delta. A severe first SARS-CoV-2 infection and age over 60 years were significant risk factors for severe reinfection.

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