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Since May 2022, an international monkeypox (MPX) outbreak has been ongoing in more than 50 countries. While most cases are men who have sex with men, transmission is not restricted to this population. In this report, we describe the case of a male child younger than 10 years with MPX in the Netherlands. Despite thorough source tracing, a likely source of infection has not been identified. No secondary cases were identified in close contacts.


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  1. Reed KD, Melski JW, Graham MB, Regnery RL, Sotir MJ, Wegner MV, et al. The detection of monkeypox in humans in the Western Hemisphere. N Engl J Med. 2004;350(4):342-50.  https://doi.org/10.1056/NEJMoa032299  PMID: 14736926 
  2. Mukinda VB, Mwema G, Kilundu M, Heymann DL, Khan AS, Esposito JJ, et al. Re-emergence of human monkeypox in Zaire in 1996. Lancet. 1997;349(9063):1449-50.  https://doi.org/10.1016/S0140-6736(05)63725-7  PMID: 9164323 
  3. Breman JG, Kalisa-Ruti, Steniowski MV, Zanotto E, Gromyko AI, Arita I. Human monkeypox, 1970-79. Bull World Health Organ. 1980;58(2):165-82. PMID: 6249508 
  4. Bunge EM, Hoet B, Chen L, Lienert F, Weidenthaler H, Baer LR, et al. The changing epidemiology of human monkeypox-A potential threat? A systematic review. PLoS Negl Trop Dis. 2022;16(2):e0010141.  https://doi.org/10.1371/journal.pntd.0010141  PMID: 35148313 
  5. Centre for Disease Prevention and Control (ECDC). Risk assessment: Monkeypox multi-country outbreak. Stockholm: ECDC; 2022. Available from: https://www.ecdc.europa.eu/en/publications-data/risk-assessment-monkeypox-multi-country-outbreak
  6. Maksyutov RA, Gavrilova EV, Shchelkunov SN. Species-specific differentiation of variola, monkeypox, and varicella-zoster viruses by multiplex real-time PCR assay. J Virol Methods. 2016;236:215-20.  https://doi.org/10.1016/j.jviromet.2016.07.024  PMID: 27477914 
  7. Li Y, Zhao H, Wilkins K, Hughes C, Damon IK. Real-time PCR assays for the specific detection of monkeypox virus West African and Congo Basin strain DNA. J Virol Methods. 2010;169(1):223-7.  https://doi.org/10.1016/j.jviromet.2010.07.012  PMID: 20643162 
  8. Isidro J, Borges V, Pinto M, Sobral D, Santos JD, Nunes A, et al. Phylogenomic characterization and signs of microevolution in the 2022 multi-country outbreak of monkeypox virus. Nat Med. 2022.  https://doi.org/10.1038/s41591-022-01907-y  PMID: 35750157 
  9. Adalja A, Inglesby T. A novel international monkeypox outbreak. Ann Intern Med. 2022;M22-1581.  https://doi.org/10.7326/M22-1581  PMID: 35605243 
  10. World Health Organization (WHO). Multi-country monkeypox outbreak: situation update. Geneva: WHO; 27 Jun 2022. Available from: https://www.who.int/emergencies/disease-outbreak-news/item/2022-DON396
  11. Miura F, van Ewijk CE, Backer JA, Xiridou M, Franz E, Op de Coul E, et al. Estimated incubation period for monkeypox cases confirmed in the Netherlands, May 2022. Euro Surveill. 2022;27(24):2200448.  https://doi.org/10.2807/1560-7917.ES.2022.27.24.2200448  PMID: 35713026 

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