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Abstract

This work evaluated neutralising antibody titres against wild type (WT) SARS-CoV-2 and four Omicron variants (BA.1, BA.2, BA.4 and BA.5) in healthcare workers who had breakthrough BA.1 infection. Omicron breakthrough infection in individuals vaccinated three or four times before infection resulted in increased neutralising antibodies against the WT virus. The fourth vaccine dose did not further improve the neutralising efficiency over the third dose against all Omicron variants, especially BA.4 and BA.5. An Omicron-specific vaccine may be indicated.

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/content/10.2807/1560-7917.ES.2022.27.30.2200559
2022-07-28
2024-05-01
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2022.27.30.2200559
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COVID-19 vaccination and BA.1 breakthrough infection induce neutralising antibodies which are less efficient against BA.4 and BA.5 Omicron variants, Israel, March to June 2022
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Limor+Kliker&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kliker Limor</a>, <a href="/search?value1=Neta+Zuckerman&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Zuckerman Neta</a>, <a href="/search?value1=Nofar+Atari&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Atari Nofar</a>, <a href="/search?value1=Noam+Barda&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Barda Noam</a>, <a href="/search?value1=Mayan+Gilboa&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gilboa Mayan</a>, <a href="/search?value1=Ital+Nemet&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Nemet Ital</a>, <a href="/search?value1=Bayan+Abd+Elkader&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Abd Elkader Bayan</a>, <a href="/search?value1=Ilana+S+Fratty&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fratty Ilana S</a>, <a href="/search?value1=Hanaa+Jaber&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jaber Hanaa</a>, <a href="/search?value1=Ella+Mendelson&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mendelson Ella</a>, <a href="/search?value1=Sharon+Alroy-Preis&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Alroy-Preis Sharon</a>, <a href="/search?value1=Yitshak+Kreiss&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kreiss Yitshak</a>, <a href="/search?value1=Gili+Regev-Yochay&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Regev-Yochay Gili</a>, <a href="/search?value1=Michal+Mandelboim&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mandelboim Michal</a></span>. COVID-19 vaccination and BA.1 breakthrough infection induce neutralising antibodies which are less efficient against BA.4 and BA.5 Omicron variants, Israel, March to June 2022 . <a href="/content/ecdc">Euro Surveill.</a> 2022;27(30):pii=2200559. <a href="https://doi.org/10.2807/1560-7917.ES.2022.27.30.2200559" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2022.27.30.2200559</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 12 Jul 2022;&nbsp;&nbsp; <span class="generated">Accepted</span>: 28 Jul 2022 </span> </p>
/content/10.2807/1560-7917.ES.2022.27.30.2200559
/content/10.2807/1560-7917.ES.2022.27.30.2200559
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