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Abstract

Infections with the Omicron SARS-CoV-2 variant are rapidly increasing worldwide. Among 174,349 SARS-CoV-2-infected individuals (≥ 12 years), we observed an increased risk of S gene target failure, predictive of the Omicron variant, in vaccinated (odds ratio (OR): 3.6; 95% confidence interval (CI): 3.4–3.7) and previously infected individuals (OR: 4.2; 95% CI: 3.8–4.7) compared with infected naïve individuals. This suggests vaccine- or infection-induced immunity against SARS-CoV-2 infections is less effective against the Omicron than the Delta variant.

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/content/10.2807/1560-7917.ES.2022.27.4.2101196
2022-01-27
2024-03-29
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2022.27.4.2101196
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