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Abstract

A nosocomial outbreak by cefiderocol (FDC)-resistant NDM-1-producing (NDM-Kp) occurred in a large tertiary care hospital from August 2021–June 2022 in Florence, Italy, an area where NDM-Kp strains have become endemic. Retrospective analysis of NDM-Kp from cases observed in January 2021–June 2022 revealed that 21/52 were FDC-resistant. The outbreak was mostly sustained by clonal expansion of a mutant with inactivated siderophore receptor gene, which exhibited high-level resistance to FDC (MIC ≥ 32 mg/L) and spread independently of FDC exposure.

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/content/10.2807/1560-7917.ES.2022.27.43.2200795
2022-10-27
2025-05-09
/content/10.2807/1560-7917.ES.2022.27.43.2200795
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Nosocomial outbreak by NDM-1-producing Klebsiella pneumoniae highly resistant to cefiderocol, Florence, Italy, August 2021 to June 2022
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Marco+Coppi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Coppi Marco</a>, <a href="/search?value1=Alberto+Antonelli&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Antonelli Alberto</a>, <a href="/search?value1=Claudia+Niccolai&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Niccolai Claudia</a>, <a href="/search?value1=Andrea+Bartolini&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bartolini Andrea</a>, <a href="/search?value1=Laura+Bartolini&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bartolini Laura</a>, <a href="/search?value1=Maddalena+Grazzini&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Grazzini Maddalena</a>, <a href="/search?value1=Elisabetta+Mantengoli&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mantengoli Elisabetta</a>, <a href="/search?value1=Alberto+Farese&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Farese Alberto</a>, <a href="/search?value1=Filippo+Pieralli&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pieralli Filippo</a>, <a href="/search?value1=Maria+Teresa+Mechi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mechi Maria Teresa</a>, <a href="/search?value1=Vincenzo+Di+Pilato&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Di Pilato Vincenzo</a>, <a href="/search?value1=Tommaso+Giani&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Giani Tommaso</a>, <a href="/search?value1=Gian+Maria+Rossolini&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rossolini Gian Maria</a></span>. Nosocomial outbreak by NDM-1-producing Klebsiella pneumoniae highly resistant to cefiderocol, Florence, Italy, August 2021 to June 2022. <a href="/content/ecdc">Euro Surveill.</a> 2022;27(43):pii=2200795. <a href="https://doi.org/10.2807/1560-7917.ES.2022.27.43.2200795" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2022.27.43.2200795</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 10 Oct 2022;&nbsp;&nbsp; <span class="generated">Accepted</span>: 26 Oct 2022 </span> </p>
/content/10.2807/1560-7917.ES.2022.27.43.2200795
/content/10.2807/1560-7917.ES.2022.27.43.2200795
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