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Abstract

Background

Epidemics of sexually transmitted infections (STI) are a major public health challenge in the World Health Organization (WHO) European Region.

Aim

We aimed to provide an overview of case reporting and other surveillance data for syphilis, gonorrhoea and chlamydia for the non-European Union (EU)/European Economic Area (EEA) countries of the Centre and East part of the WHO European Region as per classification used by the WHO Regional Office for Europe (WHO/Europe) and the European Centre for Disease Prevention and Control.

Methods

Data were provided by the surveillance agencies of the Member States for the period 2015 to 2019 through the WHO/Europe Communicable Diseases Annual Reporting Form. We analysed reported cases, explored data reported to the WHO Gonococcal Antimicrobial Surveillance Programme (GASP) and performed a review of publications on antimicrobial resistance (AMR) in gonorrhoea in the period 2015 to 2020 using systematic methodology.

Results

From 2015 to 2019, in most of the countries with three or more data points, there was a pattern of decrease in reported syphilis, gonorrhoea and chlamydia cases, which is in contrast to the EU/EEA. The number of reported cases per 100,000 population was 0.4–26.5 for syphilis, 0–18.5 for gonorrhoea and 0–43.3 for chlamydia. Four countries reported recent data on AMR in gonorrhoea to GASP, and we identified further publications from Georgia, Russia and Ukraine.

Conclusion

We found wide heterogeneity in reported rates of STI. There is a strong need to improve availability and quality of STI surveillance data in the non-EU/EEA countries.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
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2022-02-24
2024-04-25
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2022.27.8.2100197
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References

  1. Rowley J, Vander Hoorn S, Korenromp E, Low N, Unemo M, Abu-Raddad LJ, et al. Chlamydia, gonorrhoea, trichomoniasis and syphilis: global prevalence and incidence estimates, 2016. Bull World Health Organ. 2019;97(8):548-562P.  https://doi.org/10.2471/BLT.18.228486  PMID: 31384073 
  2. James C, Harfouche M, Welton NJ, Turner KM, Abu-Raddad LJ, Gottlieb SL, et al. Herpes simplex virus: global infection prevalence and incidence estimates, 2016. Bull World Health Organ. 2020;98(5):315-29.  https://doi.org/10.2471/BLT.19.237149  PMID: 32514197 
  3. World Health Organization (WHO). Global health sector strategy on sexually transmitted infections 2016-2021. Geneva: WHO; 2016. Available from: https://www.who.int/reproductivehealth/publications/rtis/ghss-stis/en
  4. World Health Organization (WHO). Strategies and laboratory methods for strengthening surveillance of sexually transmitted infection 2012. Geneva: WHO; 2012. Available from: https://www.who.int/reproductivehealth/publications/rtis/9789241504478/en
  5. Iversen J, Sabin K, Chang J, Morgan Thomas R, Prestage G, Strathdee SA, et al. COVID-19, HIV and key populations: cross-cutting issues and the need for population-specific responses. J Int AIDS Soc. 2020;23(10):e25632.  https://doi.org/10.1002/jia2.25632  PMID: 33119183 
  6. Hernando Rovirola C, Spiteri G, Sabidó M, Montoliu A, Gonzalez V, Casabona J, et al. Antimicrobial resistance in Neisseria gonorrhoeae isolates from foreign-born population in the European Gonococcal Antimicrobial Surveillance Programme. Sex Transm Infect. 2020;96(3):204-10.  https://doi.org/10.1136/sextrans-2018-053912  PMID: 32019895 
  7. European Centre for Disease Prevention and Contro (ECDC)l/World Health Organization Regional Office for Europe. HIV/AIDS surveillance in Europe 2020 (2019 data). Stockholm: ECDC; 2020. Available from: https://www.ecdc.europa.eu/en/publications-data/hivaids-surveillance-europe-2020-2019-data
  8. Lowndes CM, Fenton KA, European Surveillance of STI’s Network. Surveillance systems for STIs in the European Union: facing a changing epidemiology. Sex Transm Infect. 2004;80(4):264-71.  https://doi.org/10.1136/sti.2004.010389  PMID: 15295122 
  9. European Centre for Disease Prevention and Control (ECDC). STI laboratory diagnostics in Europe. Stockholm: ECDC; 2013. Available from: https://www.ecdc.europa.eu/en/publications-data/sti-laboratory-diagnostics-europe
  10. Joint United Nations Programme on HIV/AIDS (UNAIDS). Global AIDS monitoring 2018. Indicators for monitoring the 2016 United Nations political declaration on ending AIDS. Geneva: UNAIDS, 2017. Available from: https://reliefweb.int/report/world/global-aids-monitoring-2018-indicators-monitoring-2016-united-nations-political
  11. Joint United Nations Programme on HIV/AIDS (UNAIDS). Global AIDS monitoring 2019. Indicators for monitoring the 2016 United Nations political declaration on ending AIDS. Geneva: UNAIDS; 2018. Available from: https://digitallibrary.un.org/record/3801751?ln=en
  12. Joint United Nations Programme on HIV/AIDS (UNAIDS). Global AIDS monitoring 2020. Indicators for monitoring the 2016 United Nations political declaration on ending AIDS. Geneva: UNAIDS; 2019. Available from: https://www.childrenandaids.org/index.php/node/1159
  13. World Health Organization (WHO). WHO gonococcal AMR surveillance programme. WHO World Health Data Platform. [Accessed: 1 Feb 2021]. Available from: https://www.who.int/data/gho/data/themes/topics/who-gonococcal-amr-surveillance-programme-who-gasp
  14. Barbaric J, Bozicevic I, Kuchukhidze G. Systematic review of antimicrobial drug resistance among Neisseria gonorrhoeae isolates in non-EU countries of the World Health Organisation European Region, 2015-2019. PROSPERO: International prospective register of systematic reviews. 2021. ID: CRD42021229042 Available from: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=229042
  15. Tadesse BT, Ashley EA, Ongarello S, Havumaki J, Wijegoonewardena M, González IJ, et al. Antimicrobial resistance in Africa: a systematic review. BMC Infect Dis. 2017;17(1):616.  https://doi.org/10.1186/s12879-017-2713-1  PMID: 28893183 
  16. United Nations Department of Economic and Social Affairs (UN DESA). World Population Prospects 2019: Highlights. New York: UN DESA; 2019. Available from: https://www.un.org/development/desa/publications/world-population-prospects-2019-highlights.html
  17. World Health Organization (WHO). Global guidance on criteria and processes for validation: elimination of mother-to-child transmission of HIV and syphilis. 2nd ed. Geneva: WHO; 2017. Available from: https://www.who.int/reproductivehealth/publications/emtct-hiv-syphilis/en
  18. European Commission. Commission implementing decision (EU) 2018/945 of 22 June 2018 on the communicable diseases and related special health issues to be covered by epidemiological surveillance as well as relevant case definitions. Official Journal of the European Union. Luxembourg: Publications Office of the European Union. 6 Jul 2018. Available from: https://eur-lex.europa.eu/legal-content/EN/TXT/PDF/?uri=CELEX:32018D0945&from=EN#page=29
  19. European Centre for Disease Prevention and Control (ECDC). EU case definitions. Stockholm: ECDC. [Accessed: 4 Dec 2020]. Available from: https://www.ecdc.europa.eu/en/surveillance-and-disease-data/eu-case-definitions
  20. Washington MA, Jerse AE, Rahman N, Pilligua-Lucas M, Garges EC, Latif NH, et al. First description of a cefixime- and ciprofloxacin-resistant Neisseria gonorrhoeae isolate with mutations in key antimicrobial susceptibility-determining genes from the country of Georgia. New Microbes New Infect. 2018;24:47-51.  https://doi.org/10.1016/j.nmni.2018.04.004  PMID: 29872530 
  21. Boiko I, Golparian D, Krynytska I, Bezkorovaina H, Frankenberg A, Onuchyna M, et al. Antimicrobial susceptibility of Neisseria gonorrhoeae isolates and treatment of gonorrhoea patients in Ternopil and Dnipropetrovsk regions of Ukraine, 2013-2018. APMIS. 2019;127(7):503-9.  https://doi.org/10.1111/apm.12948  PMID: 30903707 
  22. Boiko I, Golparian D, Jacobsson S, Krynytska I, Frankenberg A, Shevchenko T, et al. Genomic epidemiology and antimicrobial resistance determinants of Neisseria gonorrhoeae isolates from Ukraine, 2013-2018. APMIS. 2020;128(7):465-75.  https://doi.org/10.1111/apm.13060  PMID: 32441045 
  23. Kubanov A, Vorobyev D, Chestkov A, Leinsoo A, Shaskolskiy B, Dementieva E, et al. Molecular epidemiology of drug-resistant Neisseria gonorrhoeae in Russia (Current Status, 2015). BMC Infect Dis. 2016;16(1):389.  https://doi.org/10.1186/s12879-016-1688-7  PMID: 27506605 
  24. Kubanov AA, Leinsoo AT, Chestkov AV, Dementieva EI, Shaskolskiy BL, Solomka VS, et al. [Drug resistance mutations and susceptibility phenotypes of Neisseria gonorrhoeae isolates in Russia]. Mol Biol (Mosk). 2017;51(3):431-41. Russian.  https://doi.org/10.1134/S0026893317030116  PMID: 28707659 
  25. Kubanov A, Solomka V, Plakhova X, Chestkov A, Petrova N, Shaskolskiy B, et al. Summary and trends of the Russian gonococcal antimicrobial surveillance programme, 2005 to 2016. J Clin Microbiol. 2019;57(6):e02024-18.  https://doi.org/10.1128/JCM.02024-18  PMID: 30894437 
  26. Shaskolskiy B, Dementieva E, Kandinov I, Filippova M, Petrova N, Plakhova X, et al. Resistance of Neisseria gonorrhoeae isolates to beta-lactam antibiotics (benzylpenicillin and ceftriaxone) in Russia, 2015-2017. PLoS One. 2019;14(7):e0220339.  https://doi.org/10.1371/journal.pone.0220339  PMID: 31344102 
  27. Shaskolskiy B, Dementieva E, Leinsoo A, Petrova N, Chestkov A, Kubanov A, et al. Tetracycline resistance of Neisseria gonorrhoeae in Russia, 2015-2017. Infect Genet Evol. 2018;63:236-42.  https://doi.org/10.1016/j.meegid.2018.06.003  PMID: 29883770 
  28. Dementieva IE, Shaskolskiy BL, Leinsoo AT, Gryadunov DA, Petrova NP, Chestkov VA, et al. Biological microchip for assessing tetracycline-resistance in Neisseria gonorrhoeae clinical isolates in Russian Federation. Infektsiya I Immun.2019;9(5-6):750-62.
  29. Břinda K, Callendrello A, Ma KC, MacFadden DR, Charalampous T, Lee RS, et al. Rapid inference of antibiotic resistance and susceptibility by genomic neighbour typing. Nat Microbiol. 2020;5(3):455-64.  https://doi.org/10.1038/s41564-019-0656-6  PMID: 32042129 
  30. Lebedzeu F, Golparian D, Titov L, Pankratava N, Glazkova S, Shimanskaya I, et al. Antimicrobial susceptibility/resistance and NG-MAST characterisation of Neisseria gonorrhoeae in Belarus, Eastern Europe, 2010-2013. BMC Infect Dis. 2015;15(1):29.  https://doi.org/10.1186/s12879-015-0755-9  PMID: 25637258 
  31. Shaskolskiy B, Dementieva E, Kandinov I, Chestkov A, Kubanov A, Deryabin D, et al. Genetic diversity of Neisseria gonorrhoeae multi-antigen sequence types in Russia and Europe. Int J Infect Dis. 2020;93:1-8.  https://doi.org/10.1016/j.ijid.2020.01.020  PMID: 31978578 
  32. European Centre for Disease Prevention and Control (ECDC). Syphilis – Annual epidemiological report for 2018. Stockholm: ECDC; 2020. Available from: https://www.ecdc.europa.eu/en/publications-data/syphilis-annual-epidemiological-report-2018
  33. European Centre for Disease Prevention and Control (ECDC). Gonorrhoea – Annual epidemiological report for 2018. Stockholm: ECDC; 2020. Available from: https://www.ecdc.europa.eu/en/publications-data/gonorrhoea-annual-epidemiological-report-2018
  34. Boiko I, Golparian D, Krynytska I, Unemo M. High prevalence of Chlamydia trachomatis, Neisseria gonorrhoeae and particularly Trichomonas vaginalis diagnosed using US FDA-approved Aptima molecular tests and evaluation of conventional routine diagnostic tests in Ternopil, Ukraine. APMIS. 2019;127(9):627-34.  https://doi.org/10.1111/apm.12975  PMID: 31225920 
  35. Unemo M, Lahra MM, Cole M, Galarza P, Ndowa F, Martin I, et al. World Health Organization Global Gonococcal Antimicrobial Surveillance Program (WHO GASP): review of new data and evidence to inform international collaborative actions and research efforts. Sex Health. 2019;16(5):412-25.  https://doi.org/10.1071/SH19023  PMID: 31437420 
  36. European Centre for Disease Prevention and Control (ECDC). Gonococcal antimicrobial susceptibility surveillance in Europe, 2017. Stockholm: ECDC; 2019. Available from: https://www.ecdc.europa.eu/en/publications-data/gonococcal-antimicrobial-susceptibility-surveillance-europe-2017
  37. World Health Organization (WHO). Global action plan to control the spread and impact of antimicrobial resistance in Neisseria gonorrhoeae. Geneva: WHO; 2012. Available from: https://www.who.int/reproductivehealth/publications/rtis/9789241503501/en
  38. World Health Organization (WHO). Laboratory diagnosis of sexually transmitted infections, including human immunodeficiency virus. Geneva: WHO; 2013. Available from: https://www.who.int/reproductivehealth/publications/rtis/9789241505840/en
Surveillance and epidemiology of syphilis, gonorrhoea and chlamydia in the non-European Union countries of the World Health Organization European Region, 2015 to 2020
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Jelena+Barbaric&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Barbaric Jelena</a>, <a href="/search?value1=Giorgi+Kuchukhidze&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kuchukhidze Giorgi</a>, <a href="/search?value1=Nicole+Seguy&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Seguy Nicole</a>, <a href="/search?value1=Elena+Vovc&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Vovc Elena</a>, <a href="/search?value1=Maria+Josefina+Theresa+Babovic&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Babovic Maria Josefina Theresa</a>, <a href="/search?value1=Teodora+Elvira+Wi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Wi Teodora Elvira</a>, <a href="/search?value1=Daniel+Low-Beer&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Low-Beer Daniel</a>, <a href="/search?value1=Ivana+Bozicevic&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bozicevic Ivana</a></span>. Surveillance and epidemiology of syphilis, gonorrhoea and chlamydia in the non-European Union countries of the World Health Organization European Region, 2015 to 2020. <a href="/content/ecdc">Euro Surveill.</a> 2022;27(8):pii=2100197. <a href="https://doi.org/10.2807/1560-7917.ES.2022.27.8.2100197" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2022.27.8.2100197</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 05 Feb 2021;&nbsp;&nbsp; <span class="generated">Accepted</span>: 06 Aug 2021 </span> </p>
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