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In 2022, a sevenfold increase in the number of notifiable invasive (iGAS) infections among children aged 0–5 years was observed in the Netherlands compared with pre-COVID-19 pandemic years. Of 42 cases in this age group, seven had preceding or coinciding varicella zoster infections, nine were fatal. This increase is not attributable to a specific type. Vigilance for clinical deterioration as iGAS sign is warranted in young children, especially those with varicella zoster infection.


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