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Abstract

A difficult-to-control outbreak of is ongoing in a large tertiary care hospital in Liguria, Italy, where it first emerged in 2019. In a retrospective analysis, 503 cases of carriage or infection were observed between July 2019 and December 2022. Genomic surveillance identified putative cases that no longer occurred as part of one defined outbreak and the emergence of echinocandin (pandrug) resistance following independent selection of S639F and F635Y mutants upon prolonged exposure to caspofungin and/or anidulafungin.

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/content/10.2807/1560-7917.ES.2023.28.14.2300161
2023-04-06
2024-04-27
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2023.28.14.2300161
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In vivo evolution to echinocandin resistance and increasing clonal heterogeneity in Candida auris during a difficult-to-control hospital outbreak, Italy, 2019 to 2022
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Giulia+Codda&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Codda Giulia</a>, <a href="/search?value1=Edward+Willison&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Willison Edward</a>, <a href="/search?value1=Laura+Magnasco&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Magnasco Laura</a>, <a href="/search?value1=Paola+Morici&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Morici Paola</a>, <a href="/search?value1=Daniele+Roberto+Giacobbe&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Giacobbe Daniele Roberto</a>, <a href="/search?value1=Antonella+Mencacci&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mencacci Antonella</a>, <a href="/search?value1=Daniele+Marini&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Marini Daniele</a>, <a href="/search?value1=Malgorzata+Mikulska&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mikulska Malgorzata</a>, <a href="/search?value1=Matteo+Bassetti&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bassetti Matteo</a>, <a href="/search?value1=Anna+Marchese&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Marchese Anna</a>, <a href="/search?value1=Vincenzo+Di+Pilato&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Di Pilato Vincenzo</a></span>. In vivo evolution to echinocandin resistance and increasing clonal heterogeneity in Candida auris during a difficult-to-control hospital outbreak, Italy, 2019 to 2022. <a href="/content/ecdc">Euro Surveill.</a> 2023;28(14):pii=2300161. <a href="https://doi.org/10.2807/1560-7917.ES.2023.28.14.2300161" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2023.28.14.2300161</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 09 Mar 2023;&nbsp;&nbsp; <span class="generated">Accepted</span>: 05 Apr 2023 </span> </p>
/content/10.2807/1560-7917.ES.2023.28.14.2300161
/content/10.2807/1560-7917.ES.2023.28.14.2300161
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