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Abstract

Background

Appropriate vaccination strategies have been key to controlling the outbreak of mpox outside endemic areas in 2022, yet few studies have provided information on mpox vaccine effectiveness (VE).

Aim

To assess VE after one dose of a third-generation smallpox vaccine against mpox when given as post-exposure prophylaxis (PEP) within 14 days.

Methods

A survival analysis in a prospective cohort of close contacts of laboratory-confirmed mpox cases was conducted from the beginning of the outbreak in the region of Madrid in May 2022. The study included contacts of cases in this region diagnosed between 17 May and 15 August 2022. Follow up was up to 49 days. A multivariate proportional hazard model was used to evaluate VE in the presence of confounding and interaction.

Results

Information was obtained from 484 close contacts, of which 230 were vaccinated within 14 days of exposure. Of the close contacts, 57 became ill during follow-up, eight vaccinated and 49 unvaccinated. The adjusted effectiveness of the vaccine was 88.8% (95% CI: 76.0–94.7). Among sexual contacts, VE was 93.6% (95% CI: 72.1–98.5) for non-cohabitants and 88.6% (95% CI: 66.1–96.2) for cohabitants.

Conclusion

Post-exposure prophylaxis of close contacts of mpox cases is an effective measure that can contribute to reducing the number of cases and eventually the symptoms of breakthrough infections. The continued use of PEP together with pre-exposure prophylaxis by vaccination and other population-targeted prevention measures are key factors in controlling an mpox outbreak.

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A corrected article has been published for this content:
Author’s correction for Euro Surveill. 2023;28(24)
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/content/10.2807/1560-7917.ES.2023.28.24.2200883
2023-06-15
2024-04-27
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2023.28.24.2200883
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Post-exposure vaccine effectiveness and contact management in the mpox outbreak, Madrid, Spain, May to August 2022
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Laura+Montero+Morales&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Montero Morales Laura</a>, <a href="/search?value1=Jos%C3%A9+Francisco+Barbas+del+Buey&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Barbas del Buey José Francisco</a>, <a href="/search?value1=Marcos+Alonso+Garc%C3%ADa&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Alonso García Marcos</a>, <a href="/search?value1=Noelia+Cenamor+Largo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cenamor Largo Noelia</a>, <a href="/search?value1=Alba+Nieto+Juli%C3%A1&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Nieto Juliá Alba</a>, <a href="/search?value1=Mar%C3%ADa+C+V%C3%A1zquez+Torres&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Vázquez Torres María C</a>, <a href="/search?value1=Susana+Jim%C3%A9nez+Bueno&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jiménez Bueno Susana</a>, <a href="/search?value1=Andr%C3%A9s+Arag%C3%B3n+Pe%C3%B1a&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Aragón Peña Andrés</a>, <a href="/search?value1=Elisa+Gil+Montalb%C3%A1n&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gil Montalbán Elisa</a>, <a href="/search?value1=Jes%C3%BAs+%C3%8D%C3%B1igo+Mart%C3%ADnez&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Íñigo Martínez Jesús</a>, <a href="/search?value1=Mar%C3%ADa+Alonso+Col%C3%B3n&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Alonso Colón María</a>, <a href="/search?value1=Araceli+Arce+Arn%C3%A1ez&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Arce Arnáez Araceli</a>, <a href="/search?value1=on+behalf+of+Madrid+Surveillance+Network+and+Vaccination+Centre+of+Madrid+Region&option1=author&noRedirect=true" class="nonDisambigAuthorLink">on behalf of Madrid Surveillance Network and Vaccination Centre of Madrid Region</a></span>. Post-exposure vaccine effectiveness and contact management in the mpox outbreak, Madrid, Spain, May to August 2022. <a href="/content/ecdc">Euro Surveill.</a> 2023;28(24):pii=2200883. <a href="https://doi.org/10.2807/1560-7917.ES.2023.28.24.2200883" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2023.28.24.2200883</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 11 Nov 2022;&nbsp;&nbsp; <span class="generated">Accepted</span>: 05 Apr 2023 </span> </p>
/content/10.2807/1560-7917.ES.2023.28.24.2200883
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