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Abstract

Echovirus 11 (E11) has recently been associated with a series of nine neonatal cases of severe hepatitis in France. Here, we present severe hepatitis caused by E11 in a pair of twins. In one of the neonates, the clinical picture evolved to fulminant hepatitis. The E11 genome showed 99% nucleotide identity with E11 strains reported in the cases in France. Rapid genome characterisation using next generation sequencing is essential to identify new and more pathogenetic variants.

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/content/10.2807/1560-7917.ES.2023.28.24.2300289
2023-06-15
2024-06-25
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2023.28.24.2300289
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References

  1. World Health Organization (WHO). Enterovirus infection – France. Geneva: WHO; 2023Available from: https://www.who.int/emergencies/disease-outbreak-news/item/2023-DON469
  2. Grapin M, Mirand A, Pinquier D, Basset A, Bendavid M, Bisseux M, et al. Severe and fatal neonatal infections linked to a new variant of echovirus 11, France, July 2022 to April 2023. Euro Surveill. 2023;28(22):2300253.  https://doi.org/10.2807/1560-7917.ES.2023.28.22.2300253  PMID: 37261730 
  3. European Centre for Disease Prevention and Control (ECDC). Weekly bulletin. Communicable Disease Threats Report. Week 18, 30 April–6 May 2023. Stockholm: ECDC; 2023. Available from: https://www.ecdc.europa.eu/en/publications-data/communicable-disease-threats-report-30-april-6-may-2023-week-18
  4. Kufner V, Plate A, Schmutz S, Braun DL, Günthard HF, Capaul R, et al. Two years of viral metagenomics in a tertiary diagnostics unit: evaluation of the first 105 cases. Genes (Basel). 2019;10(9):661.  https://doi.org/10.3390/genes10090661  PMID: 31470675 
  5. Borges V, Pinheiro M, Pechirra P, Guiomar R, Gomes JP. INSaFLU: an automated open web-based bioinformatics suite "from-reads" for influenza whole-genome-sequencing-based surveillance. Genome Med. 2018;10(1):46.  https://doi.org/10.1186/s13073-018-0555-0  PMID: 29954441 
  6. Minh BQ, Schmidt HA, Chernomor O, Schrempf D, Woodhams MD, von Haeseler A, et al. IQ-TREE 2: New models and efficient methods for phylogenetic inference in the genomic era. Mol Biol Evol. 2020;37(5):1530-4.  https://doi.org/10.1093/molbev/msaa015  PMID: 32011700 
  7. Bubba L, Broberg EK, Jasir A, Simmonds P, Harvala H, Redlberger-Fritz M, et al. Circulation of non-polio enteroviruses in 24 EU and EEA countries between 2015 and 2017: a retrospective surveillance study. Lancet Infect Dis. 2020;20(3):350-61.  https://doi.org/10.1016/S1473-3099(19)30566-3  PMID: 31870905 
  8. McWilliam Leitch EC, Cabrerizo M, Cardosa J, Harvala H, Ivanova OE, Kroes AC, et al. Evolutionary dynamics and temporal/geographical correlates of recombination in the human enterovirus echovirus types 9, 11, and 30. J Virol. 2010;84(18):9292-300.  https://doi.org/10.1128/JVI.00783-10  PMID: 20610722 
  9. Chuang YY, Huang YC. Enteroviral infection in neonates. J Microbiol Immunol Infect. 2019;52(6):851-7.  https://doi.org/10.1016/j.jmii.2019.08.018  PMID: 31607572 
  10. Wang P, Xu Y, Liu M, Li H, Wang H, Liu Y, et al. Risk factors and early markers for echovirus type 11 associated haemorrhage-hepatitis syndrome in neonates, a retrospective cohort study. Front Pediatr. 2023;11:1063558.  https://doi.org/10.3389/fped.2023.1063558  PMID: 37090924 
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