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Abstract

Background

Knowledge on the burden attributed to influenza viruses vs other respiratory viruses in children hospitalised with severe acute respiratory infections (SARI) in Belgium is limited.

Aim

This observational study aimed at describing the epidemiology and assessing risk factors for severe disease.

Methods

We retrospectively analysed data from routine national sentinel SARI surveillance in Belgium. Respiratory specimens collected during winter seasons 2011 to 2020 were tested by multiplex real-time quantitative PCR (RT-qPCR) for influenza and other respiratory viruses. Demographic data and risk factors were collected through questionnaires. Patients were followed-up for complications or death during hospital stay. Analysis focused on children younger than 15 years. Binomial logistic regression was used to identify risk factors for severe disease in relation to infection status.

Results

During the winter seasons 2011 to 2020, 2,944 specimens met the study case definition. Complications were more common in children with underlying risk factors, especially asthma (adjusted risk ratio (aRR): 1.87; 95% confidence interval (CI): 1.46–2.30) and chronic respiratory disease (aRR: 1.88; 95% CI: 1.44–2.32), regardless of infection status and age. Children infected with non-influenza respiratory viruses had a 32% higher risk of complications (aRR: 1.32; 95% CI: 1.06–1.66) compared with children with influenza only.

Conclusion

Multi-virus testing in children with SARI allows a more accurate assessment of the risk of complications and attribution of burden to respiratory viruses beyond influenza. Children with asthma and respiratory disease should be prioritised for clinical care, regardless of their virological test result and age, and targeted for prevention campaigns.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
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2023-07-20
2024-05-09
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2023.28.29.2300056
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Influenza versus other respiratory viruses – assessing severity among hospitalised children, Belgium, 2011 to 2020
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Natalie+Fischer&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fischer Natalie</a>, <a href="/search?value1=Sarah+Moreels&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Moreels Sarah</a>, <a href="/search?value1=Nicolas+Dauby&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Dauby Nicolas</a>, <a href="/search?value1=Marijke+Reynders&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Reynders Marijke</a>, <a href="/search?value1=Evelyn+Petit&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Petit Evelyn</a>, <a href="/search?value1=Mich%C3%A8le+G%C3%A9rard&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gérard Michèle</a>, <a href="/search?value1=Patrick+Lacor&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lacor Patrick</a>, <a href="/search?value1=Siel+Daelemans&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Daelemans Siel</a>, <a href="/search?value1=B%C3%A9n%C3%A9dicte+Lissoir&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lissoir Bénédicte</a>, <a href="/search?value1=Xavier+Holemans&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Holemans Xavier</a>, <a href="/search?value1=Koen+Magerman&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Magerman Koen</a>, <a href="/search?value1=Door+Jouck&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jouck Door</a>, <a href="/search?value1=Marc+Bourgeois&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bourgeois Marc</a>, <a href="/search?value1=B%C3%A9n%C3%A9dicte+Delaere&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Delaere Bénédicte</a>, <a href="/search?value1=Sophie+Quoilin&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Quoilin Sophie</a>, <a href="/search?value1=Steven+Van+Gucht&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Van Gucht Steven</a>, <a href="/search?value1=Isabelle+Thomas&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Thomas Isabelle</a>, <a href="/search?value1=Nathalie+Bossuyt&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bossuyt Nathalie</a>, <a href="/search?value1=Cyril+Barbezange&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Barbezange Cyril</a></span>. Influenza versus other respiratory viruses – assessing severity among hospitalised children, Belgium, 2011 to 2020. <a href="/content/ecdc">Euro Surveill.</a> 2023;28(29):pii=2300056. <a href="https://doi.org/10.2807/1560-7917.ES.2023.28.29.2300056" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2023.28.29.2300056</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 21 Jan 2023;&nbsp;&nbsp; <span class="generated">Accepted</span>: 29 May 2023 </span> </p>
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