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Abstract

In October 2022, an outbreak in Europe of highly pathogenic avian influenza (HPAI) A(H5N1) in intensively farmed minks occurred in northwest Spain. A single mink farm hosting more than 50,000 minks was involved. The identified viruses belong to clade 2.3.4.4b, which is responsible of the ongoing epizootic in Europe. An uncommon mutation (T271A) in the PB2 gene with potential public health implications was found. Our investigations indicate onward mink transmission of the virus may have occurred in the affected farm.

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/content/10.2807/1560-7917.ES.2023.28.3.2300001
2023-01-19
2025-05-20
/content/10.2807/1560-7917.ES.2023.28.3.2300001
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References

  1. Corman VM, Landt O, Kaiser M, Molenkamp R, Meijer A, Chu DK, et al. Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR. Euro Surveill. 2020;25(3):2000045.  https://doi.org/10.2807/1560-7917.ES.2020.25.3.2000045  PMID: 31992387 
  2. Spackman E, Senne DA, Myers TJ, Bulaga LL, Garber LP, Perdue ML, et al. Development of a real-time reverse transcriptase PCR assay for type A influenza virus and the avian H5 and H7 hemagglutinin subtypes. J Clin Microbiol. 2002;40(9):3256-60.  https://doi.org/10.1128/JCM.40.9.3256-3260.2002  PMID: 12202562 
  3. Hoffmann B, Hoffmann D, Henritzi D, Beer M, Harder TC. Riems influenza a typing array (RITA): An RT-qPCR-based low density array for subtyping avian and mammalian influenza a viruses. Sci Rep. 2016;6(1):27211.  https://doi.org/10.1038/srep27211  PMID: 27256976 
  4. Ministry of Agriculture, Fisheries and Food. Consulta de notificación de enfermedades de los animales de declaración obligatoria. [Consultation of notification of animal diseases of obligatory declaration.] Madrid: Spanish Government. [Accessed: 16 Jan 2023]. Spanish. Available from: https://servicio.mapa.gob.es/rasve/Publico/Publico/BuscadorFocos.aspx
  5. European Commission. Commission Implementing Decision (EU) 2021/788 of 12 May 2021 laying down rules for the monitoring and reporting of infections with SARS-CoV-2 in certain animal species. Official Journal of the European Union. Luxembourg: Publications Office of the European Union. 15.5.2021: L173. Available from: https://eur-lex.europa.eu/legal-content/EN/TXT/PDF/?uri=CELEX:32021D0788&from=GA
  6. Adlhoch C, Fusaro A, Gonzales JL, Kuiken T, Marangon S, Niqueux É, et al. Avian influenza overview December 2020 - February 2021. EFSA J. 2021;19(3):e06497.  PMID: 33717356 
  7. Bussey KA, Bousse TL, Desmet EA, Kim B, Takimoto T. PB2 residue 271 plays a key role in enhanced polymerase activity of influenza A viruses in mammalian host cells. J Virol. 2010;84(9):4395-406.  https://doi.org/10.1128/JVI.02642-09  PMID: 20181719 
  8. Oreshkova N, Molenaar RJ, Vreman S, Harders F, Oude Munnink BB, Hakze-van der Honing RW, et al. SARS-CoV-2 infection in farmed minks, the Netherlands, April and May 2020. Euro Surveill. 2020;25(23):2001005.  https://doi.org/10.2807/1560-7917.ES.2020.25.23.2001005  PMID: 32553059 
  9. Zhang Y, Zhang Q, Gao Y, He X, Kong H, Jiang Y, et al. Key molecular factors in hemagglutinin and PB2 contribute to efficient transmission of the 2009 H1N1 pandemic influenza virus. J Virol. 2012;86(18):9666-74.  https://doi.org/10.1128/JVI.00958-12  PMID: 22740390 
  10. Sun H, Li F, Liu Q, Du J, Liu L, Sun H, et al. Mink is a highly susceptible host species to circulating human and avian influenza viruses. Emerg Microbes Infect. 2021;10(1):472-80.  https://doi.org/10.1080/22221751.2021.1899058  PMID: 33657971 
  11. Peng L, Chen C, Kai-yi H, Feng-xia Z, Yan-li Z, Zong-shuai L, et al. Molecular characterization of H9N2 influenza virus isolated from mink and its pathogenesis in mink. Vet Microbiol. 2015;176(1-2):88-96.  https://doi.org/10.1016/j.vetmic.2015.01.009  PMID: 25655813 
  12. Liu J, Li Z, Cui Y, Yang H, Shan H, Zhang C. Emergence of an Eurasian avian-like swine influenza A (H1N1) virus from mink in China. Vet Microbiol. 2020;240:108509.  https://doi.org/10.1016/j.vetmic.2019.108509  PMID: 31902506 
  13. Gagnon CA, Spearman G, Hamel A, Godson DL, Fortin A, Fontaine G, et al. Characterization of a Canadian mink H3N2 influenza A virus isolate genetically related to triple reassortant swine influenza virus. J Clin Microbiol. 2009;47(3):796-9.  https://doi.org/10.1128/JCM.01228-08  PMID: 19116358 
  14. Kiss I, Gyarmati P, Zohari S, Ramsay KW, Metreveli G, Weiss E, et al. Molecular characterization of highly pathogenic H5N1 avian influenza viruses isolated in Sweden in 2006. Virol J. 2008;5(1):113.  https://doi.org/10.1186/1743-422X-5-113  PMID: 18837987 
  15. Fenollar F, Mediannikov O, Maurin M, Devaux C, Colson P, Levasseur A, et al. Mink, SARS-CoV-2, and the human-animal interface. Front Microbiol. 2021;12:663815.  https://doi.org/10.3389/fmicb.2021.663815  PMID: 33868218 
  16. He G, Qiao J, Dong C, He C, Zhao L, Tian Y. Amantadine-resistance among H5N1 avian influenza viruses isolated in Northern China. Antiviral Res. 2008;77(1):72-6.  https://doi.org/10.1016/j.antiviral.2007.08.007  PMID: 17897729 
  17. Bandelt H-J, Forster P, Röhl A. Median-joining networks for inferring intraspecific phylogenies. Mol Biol Evol. 1999;16(1):37-48.  https://doi.org/10.1093/oxfordjournals.molbev.a026036  PMID: 10331250 
Highly pathogenic avian influenza A(H5N1) virus infection in farmed minks, Spain, October 2022
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Montserrat+Ag%C3%BCero&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Agüero Montserrat</a>, <a href="/search?value1=Isabella+Monne&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Monne Isabella</a>, <a href="/search?value1=Azucena+S%C3%A1nchez&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sánchez Azucena</a>, <a href="/search?value1=Bianca+Zecchin&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Zecchin Bianca</a>, <a href="/search?value1=Alice+Fusaro&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fusaro Alice</a>, <a href="/search?value1=Mar%C3%ADa+Jos%C3%A9+Ruano&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ruano María José</a>, <a href="/search?value1=Manuel+del+Valle+Arrojo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">del Valle Arrojo Manuel</a>, <a href="/search?value1=Ricardo+Fern%C3%A1ndez-Antonio&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fernández-Antonio Ricardo</a>, <a href="/search?value1=Antonio+Manuel+Souto&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Souto Antonio Manuel</a>, <a href="/search?value1=Pedro+Tordable&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Tordable Pedro</a>, <a href="/search?value1=Julio+Ca%C3%B1%C3%A1s&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cañás Julio</a>, <a href="/search?value1=Francesco+Bonfante&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bonfante Francesco</a>, <a href="/search?value1=Edoardo+Giussani&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Giussani Edoardo</a>, <a href="/search?value1=Calogero+Terregino&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Terregino Calogero</a>, <a href="/search?value1=Jes%C3%BAs+Javier+Orejas&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Orejas Jesús Javier</a></span>. Highly pathogenic avian influenza A(H5N1) virus infection in farmed minks, Spain, October 2022. <a href="/content/ecdc">Euro Surveill.</a> 2023;28(3):pii=2300001. <a href="https://doi.org/10.2807/1560-7917.ES.2023.28.3.2300001" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2023.28.3.2300001</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 02 Jan 2023;&nbsp;&nbsp; <span class="generated">Accepted</span>: 18 Jan 2023 </span> </p>
/content/10.2807/1560-7917.ES.2023.28.3.2300001
/content/10.2807/1560-7917.ES.2023.28.3.2300001
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