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Abstract

During predominant circulation of SARS-CoV-2 Omicron XBB.1.5 and other XBB sublineages (April–June 2023), we found that a second or third booster of Comirnaty bivalent Original/Omicron BA.4-5 mRNA vaccine, versus a first booster received at least 120 days earlier, was effective in preventing severe COVID-19 for more than 6 months post-administration in persons 60 years and above. In view of autumn 2023 vaccination campaigns, use of bivalent Original/Omicron BA.4-5 mRNA vaccines might be warranted until monovalent COVID-19 vaccines targeting Omicron XBB.1 sublineages become available.

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/content/10.2807/1560-7917.ES.2023.28.32.2300397
2023-08-10
2024-04-27
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2023.28.32.2300397
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Relative effectiveness of bivalent Original/Omicron BA.4-5 mRNA vaccine in preventing severe COVID-19 in persons 60 years and above during SARS-CoV-2 Omicron XBB.1.5 and other XBB sublineages circulation, Italy, April to June 2023
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Massimo+Fabiani&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fabiani Massimo</a>, <a href="/search?value1=Alberto+Mateo-Urdiales&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mateo-Urdiales Alberto</a>, <a href="/search?value1=Chiara+Sacco&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sacco Chiara</a>, <a href="/search?value1=Maria+Cristina+Rota&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rota Maria Cristina</a>, <a href="/search?value1=Emmanouil+Alexandros+Fotakis&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fotakis Emmanouil Alexandros</a>, <a href="/search?value1=Daniele+Petrone&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Petrone Daniele</a>, <a href="/search?value1=Martina+Del+Manso&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Del Manso Martina</a>, <a href="/search?value1=Andrea+Siddu&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Siddu Andrea</a>, <a href="/search?value1=Paola+Stefanelli&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Stefanelli Paola</a>, <a href="/search?value1=Antonino+Bella&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bella Antonino</a>, <a href="/search?value1=Flavia+Riccardo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Riccardo Flavia</a>, <a href="/search?value1=Giovanni+Rezza&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rezza Giovanni</a>, <a href="/search?value1=Anna+Teresa+Palamara&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Palamara Anna Teresa</a>, <a href="/search?value1=Silvio+Brusaferro&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Brusaferro Silvio</a>, <a href="/search?value1=Patrizio+Pezzotti&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pezzotti Patrizio</a>, <a href="/search?value1=on+behalf+of+the+Italian+Integrated+Surveillance+of+COVID-19+study+group+and+of+the+Italian+COVID-19+Vaccines+Registry+group&option1=author&noRedirect=true" class="nonDisambigAuthorLink">on behalf of the Italian Integrated Surveillance of COVID-19 study group and of the Italian COVID-19 Vaccines Registry group</a></span>. Relative effectiveness of bivalent Original/Omicron BA.4-5 mRNA vaccine in preventing severe COVID-19 in persons 60 years and above during SARS-CoV-2 Omicron XBB.1.5 and other XBB sublineages circulation, Italy, April to June 2023. <a href="/content/ecdc">Euro Surveill.</a> 2023;28(32):pii=2300397. <a href="https://doi.org/10.2807/1560-7917.ES.2023.28.32.2300397" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2023.28.32.2300397</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 26 Jul 2023;&nbsp;&nbsp; <span class="generated">Accepted</span>: 09 Aug 2023 </span> </p>
/content/10.2807/1560-7917.ES.2023.28.32.2300397
/content/10.2807/1560-7917.ES.2023.28.32.2300397
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