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Abstract

We describe 10 cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant BA.2.86 detected in Denmark, including molecular characteristics and results from wastewater surveillance that indicate that the variant is circulating in the country at a low level. This new variant with many spike gene mutations was classified as a variant under monitoring by the World Health Organization on 17 August 2023. Further global monitoring of COVID-19, BA.2.86 and other SARS-CoV-2 variants is highly warranted.

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/content/10.2807/1560-7917.ES.2023.28.36.2300460
2023-09-07
2024-10-16
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2023.28.36.2300460
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References

  1. Schønning K, Dessau RB, Jensen TG, Thorsen NM, Wiuff C, Nielsen L, et al. Electronic reporting of diagnostic laboratory test results from all healthcare sectors is a cornerstone of national preparedness and control of COVID-19 in Denmark. APMIS. 2021;129(7):438-51.  https://doi.org/10.1111/apm.13140  PMID: 33949007 
  2. The Danish Health Authority. Covid-19 test, symptoms, and early treatment. Copenhagen: Danish Health Authority. [Accessed: 28 Aug 2023]. Available from: https://www.sst.dk/en/english/Corona-eng/Guidelines-vaccination-and-disease-prevention/Test-symptoms-and-early-treatment
  3. Statens Serum Institut (SSI). Virus monitoring at work. Copenhagen: SSI. [Accessed: 28 Aug 2023]. Available from: https://tcdk.ssi.dk/english/virus-monitoring-in-denmark
  4. Jessen R, Nielsen L, Larsen NB, Cohen AS, Gunalan V, Marving E, et al. A RT-qPCR system using a degenerate probe for specific identification and differentiation of SARS-CoV-2 Omicron (B.1.1.529) variants of concern. PLoS One. 2022;17(10):e0274889.  https://doi.org/10.1371/journal.pone.0274889  PMID: 36197885 
  5. Rihn SJ, Merits A, Bakshi S, Turnbull ML, Wickenhagen A, Alexander AJT, et al. A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research. PLoS Biol. 2021;19(2):e3001091.  https://doi.org/10.1371/journal.pbio.3001091  PMID: 33630831 
  6. Lyngse FP, Kirkeby CT, Denwood M, Christiansen LE, Mølbak K, Møller CH, et al. Household transmission of SARS-CoV-2 Omicron variant of concern subvariants BA.1 and BA.2 in Denmark. Nat Commun. 2022;13(1):5760.  https://doi.org/10.1038/s41467-022-33498-0  PMID: 36180438 
  7. Drummond AJ, Rambaut A. BEAST: Bayesian evolutionary analysis by sampling trees. BMC Evol Biol. 2007;7(1):214.  https://doi.org/10.1186/1471-2148-7-214  PMID: 17996036 
  8. Karthikeyan S, Levy JI, De Hoff P, Humphrey G, Birmingham A, Jepsen K, et al. Wastewater sequencing reveals early cryptic SARS-CoV-2 variant transmission. Nature. 2022;609(7925):101-8.  https://doi.org/10.1038/s41586-022-05049-6  PMID: 35798029 
  9. McManus O, Christiansen LE, Nauta M, Krogsgaard LW, Bahrenscheer NS, von Kappelgaard L, et al. Predicting COVID-19 incidence using wastewater surveillance data, Denmark, October 2021-June 2022. Emerg Infect Dis. 2023;29(8):1589-97.  https://doi.org/10.3201/eid2908.221634  PMID: 37486168 
  10. Katoh K, Standley DM. MAFFT multiple sequence alignment software version 7: improvements in performance and usability. Mol Biol Evol. 2013;30(4):772-80.  https://doi.org/10.1093/molbev/mst010  PMID: 23329690 
  11. Nguyen LT, Schmidt HA, von Haeseler A, Minh BQ. IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies. Mol Biol Evol. 2015;32(1):268-74.  https://doi.org/10.1093/molbev/msu300  PMID: 25371430 
  12. Kalyaanamoorthy S, Minh BQ, Wong TKF, von Haeseler A, Jermiin LS. ModelFinder: fast model selection for accurate phylogenetic estimates. Nat Methods. 2017;14(6):587-9.  https://doi.org/10.1038/nmeth.4285  PMID: 28481363 
  13. Tamura K, Stecher G, Kumar S. MEGA11: Molecular Evolutionary Genetics Analysis Version 11. Mol Biol Evol. 2021;38(7):3022-7.  https://doi.org/10.1093/molbev/msab120  PMID: 33892491 
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