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Abstract

Enteroviruses are a common cause of seasonal childhood infections. The vast majority of enterovirus infections are mild and self-limiting, although neonates can sometimes develop severe disease. Myocarditis is a rare complication of enterovirus infection. Between June 2022 and April 2023, twenty cases of severe neonatal enteroviral myocarditis caused by coxsackie B viruses were reported in the United Kingdom. Sixteen required critical care support and two died. Enterovirus PCR on whole blood was the most sensitive diagnostic test. We describe the initial public health investigation into this cluster and aim to raise awareness among paediatricians, laboratories and public health specialists.

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/content/10.2807/1560-7917.ES.2023.28.39.2300313
2023-09-28
2024-04-29
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2023.28.39.2300313
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Increased reports of severe myocarditis associated with enterovirus infection in neonates, United Kingdom, 27 June 2022 to 26 April 2023
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Anika+Singanayagam&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Singanayagam Anika</a>, <a href="/search?value1=Catherine+Moore&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Moore Catherine</a>, <a href="/search?value1=Susannah+Froude&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Froude Susannah</a>, <a href="/search?value1=Cristina+Celma&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Celma Cristina</a>, <a href="/search?value1=Julia+Stowe&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Stowe Julia</a>, <a href="/search?value1=Erjola+Hani&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hani Erjola</a>, <a href="/search?value1=Khuen+Foong+Ng&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ng Khuen Foong</a>, <a href="/search?value1=Peter+Muir&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Muir Peter</a>, <a href="/search?value1=Marion+Roderick&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Roderick Marion</a>, <a href="/search?value1=Simon+Cottrell&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cottrell Simon</a>, <a href="/search?value1=David+F.+Bibby&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bibby David F.</a>, <a href="/search?value1=Barry+Vipond&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Vipond Barry</a>, <a href="/search?value1=Sophie+Gillett&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gillett Sophie</a>, <a href="/search?value1=Peter+J.+Davis&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Davis Peter J.</a>, <a href="/search?value1=Jack+Gibb&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gibb Jack</a>, <a href="/search?value1=Mai+Barry&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Barry Mai</a>, <a href="/search?value1=Phillippa+Harris&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Harris Phillippa</a>, <a href="/search?value1=Frances+Rowley&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rowley Frances</a>, <a href="/search?value1=Jiao+Song&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Song Jiao</a>, <a href="/search?value1=Ananda+Giri+Shankar&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Shankar Ananda Giri</a>, <a href="/search?value1=Danielle+McMichael&option1=author&noRedirect=true" class="nonDisambigAuthorLink">McMichael Danielle</a>, <a href="/search?value1=Jonathan+M.+Cohen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cohen Jonathan M.</a>, <a href="/search?value1=Abirami+Manian&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Manian Abirami</a>, <a href="/search?value1=Ciaran+Harvey&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Harvey Ciaran</a>, <a href="/search?value1=Louise+Shaw+Primrose&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Primrose Louise Shaw</a>, <a href="/search?value1=Stefanie+Wilson&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Wilson Stefanie</a>, <a href="/search?value1=Declan+T.+Bradley&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bradley Declan T.</a>, <a href="/search?value1=Karthik+Paranthaman&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Paranthaman Karthik</a>, <a href="/search?value1=Stuart+Beard&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Beard Stuart</a>, <a href="/search?value1=Maria+Zambon&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Zambon Maria</a>, <a href="/search?value1=Mary+Ramsay&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ramsay Mary</a>, <a href="/search?value1=Vanessa+Saliba&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Saliba Vanessa</a>, <a href="/search?value1=Shamez+Ladhani&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ladhani Shamez</a>, <a href="/search?value1=Christopher+Williams&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Williams Christopher</a></span>. Increased reports of severe myocarditis associated with enterovirus infection in neonates, United Kingdom, 27 June 2022 to 26 April 2023. <a href="/content/ecdc">Euro Surveill.</a> 2023;28(39):pii=2300313. <a href="https://doi.org/10.2807/1560-7917.ES.2023.28.39.2300313" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2023.28.39.2300313</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 25 Jun 2023;&nbsp;&nbsp; <span class="generated">Accepted</span>: 27 Aug 2023 </span> </p>
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