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Abstract

A community cluster of influenza A(H3N2) caused by viruses with an E199G substitution in PA was detected in Nara, Japan, between February and March 2023. The three patients with these mutant viruses had not received antiviral treatment before specimen collection but patients in the same hospital had. The sequences of the mutant viruses were closely related, suggesting clonal spread in Nara. They showed reduced susceptibility to baloxavir in vitro; however, the clinical significance of the PA E199G substitution remains unclear.

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/content/10.2807/1560-7917.ES.2023.28.39.2300501
2023-09-28
2024-05-20
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2023.28.39.2300501
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A community cluster of influenza A(H3N2) virus infection with reduced susceptibility to baloxavir due to a PA E199G substitution in Japan, February to March 2023
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Emi+Takashita&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Takashita Emi</a>, <a href="/search?value1=Seiichiro+Fujisaki&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fujisaki Seiichiro</a>, <a href="/search?value1=Hiroko+Morita&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Morita Hiroko</a>, <a href="/search?value1=Shiho+Nagata&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Nagata Shiho</a>, <a href="/search?value1=Hideka+Miura&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Miura Hideka</a>, <a href="/search?value1=Yuki+Matsuura&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Matsuura Yuki</a>, <a href="/search?value1=Saya+Yamamoto&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Yamamoto Saya</a>, <a href="/search?value1=Shoko+Chiba&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Chiba Shoko</a>, <a href="/search?value1=Yumiko+Inoue&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Inoue Yumiko</a>, <a href="/search?value1=Iori+Minami&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Minami Iori</a>, <a href="/search?value1=Sayaka+Yoshikawa&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Yoshikawa Sayaka</a>, <a href="/search?value1=Seiko+Yamazaki&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Yamazaki Seiko</a>, <a href="/search?value1=Noriko+Kishida&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kishida Noriko</a>, <a href="/search?value1=Kazuya+Nakamura&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Nakamura Kazuya</a>, <a href="/search?value1=Masayuki+Shirakura&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Shirakura Masayuki</a>, <a href="/search?value1=Shinji+Watanabe&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Watanabe Shinji</a>, <a href="/search?value1=Hideki+Hasegawa&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hasegawa Hideki</a></span>. A community cluster of influenza A(H3N2) virus infection with reduced susceptibility to baloxavir due to a PA E199G substitution in Japan, February to March 2023. <a href="/content/ecdc">Euro Surveill.</a> 2023;28(39):pii=2300501. <a href="https://doi.org/10.2807/1560-7917.ES.2023.28.39.2300501" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2023.28.39.2300501</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 20 Sept 2023;&nbsp;&nbsp; <span class="generated">Accepted</span>: 26 Sept 2023 </span> </p>
/content/10.2807/1560-7917.ES.2023.28.39.2300501
/content/10.2807/1560-7917.ES.2023.28.39.2300501
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